Congener-Specific Levels of Dioxins and Dibenzofurans in U.S. Food and Estimated Daily Dioxin Toxic Equivalent Intake

Schecter, Arnold; Startin, James R.; Wright, Christopher; Kelly, Mitchell; Päpke, Olaf; Lis, A.; Ball, Michael; Olson, James R.

doi:10.2307/3431919

Cited by 48 publications

(30 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the second home, cows were also raised; the beef fat contained 27.2 pg ITEQ/g. Similar samples from commercial stores in the area contained 10-to 100-fold lower levels (24) that were equivalent to levels reported in commercial U.S. food by others (3,25).…”

Section: Site Historysupporting

confidence: 65%

Serum polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans among people eating contaminated home-produced eggs and beef.

Goldman

Harnly

Flattery

et al. 2000

Environ Health Perspect

View full text Add to dashboard Cite

We compared serum polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) among residents of two homes to levels among age-and sex-matched comparison subjects. The residents of the two homes consumed contaminated eggs and beef from animals raised at the homes. The animals had greater soil contact than those raised with conventional commercial husbandry practices. The comparison subjects were from a similar rural area, but did not consume home-produced beefand eggs. Serum levels of2,3,7,8-substituted tetr-, penta-, and hexaCDDs and penta-, hexa-, and heptaCDFs were increased between 2-and 6-fold in residents from one home; contaminated eggs and beef were consumed by residents for 2-15 years. Elevations were less for those in the other index home, where only home-produced eggs were consumed for 2 years; a 3-fold elevation of 1,2,3,7,8,9-hexaCDD as compared to controls was most apparent. Very strong bivariate correlations among ali of the 2,3,7,8 penta-and hexaCDDs/CDFs were observed. The elevations observed verify that PCDD/PCDF-containated food contributed to the body burden ofthese compounds. The blood levels among the highest exposed participants are generally higher than those observed in other studies of U.S. contaminated-fish consumers and higher than average adipose tissue levels observed in U.S. urban populations. There are suffident animal toxicologic and human epidemiologic data to recommend that exposures be reduced. In the study area, pentachlorophenol and pentachlorophenol incineration sources have been identified, and the animal contamination and blood elevations probably reflect these sources. Soil reference values and site-specific risk assessments should indude estimates of exposures to contamination in home-produced animal products. Such estimates can be verified with limited PCDD/PCDF sampling of animals and humans. Key work beef, chicken eggs, dietary intake, food contamination, human blood levels, polychlorinated dibenzofiuras, polychlorinated dibenzop-dioxins.

show abstract

Section: Site Historysupporting

confidence: 65%

Serum polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans among people eating contaminated home-produced eggs and beef.

Goldman

Harnly

Flattery

et al. 2000

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…Therefore, humans, wildlife, and laboratory animals are exposed daily to a complex mixture of these chemicals via trace amounts present in food and the environment [1,2]. Due to their hydrophobic nature and resistance to metabolism, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related PHAH congeners accumulate in tissues of exposed populations [1][2][3][4][5]. Therefore, repeated exposures to small amounts of PHAH may evoke adverse health effects due to chronic accumulation in target tissues [6].…”

Section: Introductionmentioning

confidence: 99%

Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons

Jeong

Walker

Burgin

et al. 2008

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Oxidative DNA damage is one of the key events thought to be involved in mutation and cancer. The present study examined the accumulation of M 1 dG, 3-(2′-deoxy-β-D-erythro-pentofuranosyl)-pyrimido[1,2-a]-purin-10(3H)-one, DNA adducts after single dose or one-year exposure to polyhalogenated aromatic hydrocarbons (PHAH) in order to evaluate the potential role of oxidative DNA damage in PHAH toxicity and carcinogenicity. The effect of PHAH exposure on the number of M 1 dG adducts was explored initially in female mice exposed to a single dose of either 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or a PHAH mixture. This study demonstrated that a single exposure to PHAH had no significant effect on the number of M 1 dG adducts compared to the corn oil control group. The role of M 1 dG adducts in polychlorinated biphenyl (PCB) induced toxicity and carcinogenicity was further investigated in rats exposed for a year to PCB 153, PCB 126, or a mixture of the two. PCB 153, at doses up to 3000 μg/kg/d, had no significant effect on the number of M 1 dG adducts in liver and brain tissues from the exposed rats compared to controls. However, 1000 ng/kg/ d of PCB 126 resulted in M 1 dG adduct accumulation in the liver. More importantly, co-administration of equal proportions of PCB 153 and PCB 126 resulted in dose-dependent increases in M 1 dG adduct accumulation in the liver from 300-1000 ng/kg/d of PCB 126 with 300-1000 μg/kg/d of PCB 153. Interestingly, the co-administration of different amounts of PCB 153 with fixed amounts of PCB 126 demonstrated more M 1 dG adduct accumulation with higher doses of PCB 153. These results are consistent with the results from cancer bioassays that demonstrated a synergistic effect between PCB 126 and PCB 153 on toxicity and tumor development. In summary, the results from the present study support the hypothesis that oxidative DNA damage plays a key role in toxicity and carcinogenicity following long-term PCB exposure.

show abstract

“…In addition, certain polyhalogenated biphenyls, naphthalenes, and diphenyl ethers are Ah receptor agonists. Humans are exposed to complex mixtures of these chemicals; estimates of daily exposure to TCDD or "dioxinlike" (all 2,3,7,8-halogenated dibenzo-p-dioxins and dibenzofurans as well as the dioxinlike polychlorinated biphenyls) chemicals is 3-6 pg TCDD equivalents/kg/day in the United States (15,16). The subclass of the polyhalogenated aromatic hydrocarbons with dioxinlike activity are referred to as dioxins in this article.…”

mentioning

confidence: 99%

Comparisons of Estimated Human Body Burdens of Dioxinlike Chemicals and TCDD Body Burdens in Experimentally Exposed Animals

DeVito¹,

Birnbaum²,

Farland³

et al. 1995

Environmental Health Perspectives

View full text Add to dashboard Cite

Congener-Specific Levels of Dioxins and Dibenzofurans in U.S. Food and Estimated Daily Dioxin Toxic Equivalent Intake

Abstract: A portion of this work was funded by the Warsh-Mott Legacy of the CS Fund. Thanks are extended to Avi Silber, Frank Leu, and Ruth Stento for manuscript preparation.

Cited by 48 publications

References 16 publications

Serum polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans among people eating contaminated home-produced eggs and beef.

Serum polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans among people eating contaminated home-produced eggs and beef.

Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons

Comparisons of Estimated Human Body Burdens of Dioxinlike Chemicals and TCDD Body Burdens in Experimentally Exposed Animals

Contact Info

Product

Resources

About