Congenital abnormalities of the urogenital tract in association with congenital vertebral malformations

Abstract

There is a close link between the embryological development of the musculoskeletal system and all other main organ systems. We report a prospective series of 202 patients with congenital vertebral abnormalities and document the associated abnormalities in other systems. There were 100 boys and 102 girls. In 153 there were 460 associated abnormalities, a mean of 2.27 abnormalities for each patient. Intravenous pyelography was carried out on 173 patients (85.6%) and ultrasonography on the remaining 29 (14.4%). Patients with genitourinary anomalies were more likely to have musculoskeletal (p = 0.002), gastrointestinal (p = 0.02) and cardiac abnormalities (p = 0.008) than those without genitourinary involvement. A total of 54 (26.7%) had at least one genitourinary abnormality, the most frequent being unilateral renal agenesis. There was urinary obstruction in six (3%). There was no association between genitourinary abnormality and the place of birth, parental age, birth order, level of spinal curvature, or the number, type and side of spinal anomaly. There was, however, a statistically significant association (p = 0.04) between costal and genitourinary abnormalities. The incidence of genitourinary abnormalities (26.7%) was similar to that of previously reported series. The diagnosis of a congenital vertebral abnormality should alert the clinician to a wide spectrum of possible associated anomalies most of which are of clinical importance.

Cross-sectional analysis and trend of vertebral and associated anomalies in Chinese congenital scoliosis population: a retrospective study of one thousand, two hundred and eighty nine surgical cases from 2010 to 2019

“…We supposed that as China is still a developing country, patients with congenital heart disease from economically underdeveloped areas may prioritize treatment of heart disease; thus, they are unable to have their CS treated surgically due to economic burden. The incidence of genitourinary defects (5.8%) was lower in our study than in previous studies [7,11,13,17,18]. In our hospital, urogenital ultrasound is a routine examination for CS patients, but intravenous pyelogram was an uncommon examination.…”

“…Among all kinds of congenital defects, intraspinal, cardiovascular, and genitourinary defects are the most common. Several previous studies have reported the incidences of different congenital defects in CS patients [7,[10][11][12][13][14][15][16][17][18][19]. However, the incidences varied greatly in different studies, and the interrelationship among these anomalies and the trend in recent years has not been fully clarified.…”

Increasing Prevalence and High Risk of Associated Anomalies in Congenital Vertebral Defects: A Population-based Study

“… 7 , 29 In our cohort, VACTERL association was the most common syndromic condition explaining significantly higher risk of anomalies in other organ systems related to this condition (cardiac, urinary, limb, and digestive system) observed in our study. In line with our findings, the association between vertebral anomalies and cleft lip and/or palate 30 and abnormalities of the urogenital tract 31 have also been reported earlier.…”

Lump type crossed fused renal ectopia with bilateral vesicoureteral reflux: A case report

“…It has been suggested that there is a significant correlation between genitourinary abnormalities and malformations such as musculoskeletal, gastrointestinal, and cardiovascular anomalies[5]. For this reason, early and complete evaluation is needed for the patient with crossed renal ectopia.…”