Congenital brucellosis: case report

Doğan, Derya Gümüş; Aslan, Mehtap Hülya; Menekşe, Engin; Yakıncı, Cengiz

doi:10.1179/146532810x12786388978724

Cited by 16 publications

(15 citation statements)

References 13 publications

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“…Genitourinary brucellosis in female patients is known to be associated with intrauterine infection, foetal death, premature delivery, abortion and low birth weight, particularly within the first and second trimesters . In addition, surviving newborns may experience serious sequelae . One‐sixth of female patients in this study were pregnant and all with gestational ages less than 32 weeks.…”

Section: Discussionmentioning

confidence: 86%

Genitourinary brucellosis: results of a multicentric study

Erdem

Elaldı

et al. 2014

Clinical Microbiology and Infection

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This study reviewed the clinical, laboratory, therapeutic and prognostic data on genitourinary involvement of brucellosis in this largest case series reported. This multicentre study pooled adult patients with genitourinary brucellar involvement from 34 centres treated between 2000 and 2013. Diagnosis of the disease was established by conventional methods. Overall 390 patients with genitourinary brucellosis (352 male, 90.2%) were pooled. In male patients, the most frequent involved site was the scrotal area (n=327, 83.8%), as epididymo-orchitis (n=204, 58%), orchitis (n=112, 31.8%) and epididymitis (n=11, 3.1%). In female patients, pyelonephritis (n=33/38, 86.8%) was significantly higher than in male patients (n=11/352, 3.1%; p<0.0001). The mean blood leukocyte count was 7530±3115/mm3. Routine laboratory analysis revealed mild to moderate increases for erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The mean treatment duration and length of hospital stay were significantly higher when there were additional brucellar foci (p<0.05). Surgical operations including orchiectomy and abscess drainage were performed in nine (2.3%) patients. Therapeutic failure was detected in six (1.5%), relapse occurred in four (1%), and persistent infertility related to brucellosis occurred in one patient. A localized scrotal infection in men or pyelonephritis in women in the absence of leucocytosis and with mild to moderate increases in inflammatory markers should signal the possibility of brucellar genitourinary disease.

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Section: Discussionmentioning

confidence: 86%

Genitourinary brucellosis: results of a multicentric study

Erdem

Elaldı

et al. 2014

Clinical Microbiology and Infection

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“…Therefore, the differential clinical diagnosis of congenital brucellosis is very crucial. The main findings in congenital brucellosis cases reported in the literature was respiratory distress syndrome associated with sepsis, preterm birth and meconium aspiration syndrome (33,(66)(67)(68). Brucella species can be transmitted transplacentally during delivery and by breast feeding in postpartum period (69).…”

Section: Congenital Brucellosismentioning

confidence: 99%

The Effect of Brucellosis on Women’s Health and Reproduction

Kurdoğlu¹,

Cetin²,

Kurdoğlu³

et al. 2015

IJWHR

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IntroductionBrucellosis is a zoonotic disease of worldwide distribution which still remains endemic in some developing countries, causing devastating economic losses. Since it is transmissible to humans through direct contact with infected animals, consumption of their milk and dairy products, or inhalation of contaminated aerosols, it is considered a big threat for public health. At this point, the effect of Brucella infection on women's health and reproduction gains an extraordinary importance due to its potential harmful effects on female reproductive system and pregnancy. Therefore, in this report we aimed to review the available literature related to human brucellosis in order to characterize the basic microbiological features as well as the risk factors and clinical presentations of the disease and its complications related to various aspects of reproductive health. Materials and MethodsIn order to look for original articles, review articles, case series, case reports and editorials related to the effects of brucellosis on women's health and reproduction, various internet engines including PubMed, Up To Date, Google, Google Scholar and Cochrane Library were searched between February 2015 and June 2015. Directly or indirectly related information from 75 reports, the earliest reported in 1917 and the latest in 2015 were identified. The words used during the search process were "Brucella," "brucellosis, " "women's health, " "human pregnancy, " "human reproduction, " "abortion, " "preterm birth, " "intrauterine fetal demise, " and "intrauterine fetal death". Results General Features of Brucella Species and InfectionThe main pathogenic species worldwide are Brucella abortus (B. abortus), responsible for bovine brucellosis, Brucella melitensis (B. melitensis), the main etiologic agent of ovine and caprine brucellosis, and Brucella suis (B. suis), which has a wide host range, not being confined to swine (1). B. melitensis is responsible for the majority of human infections and is primarily food-borne. B. abortus and B. suis infections are generally sporadic and Brucella canis infections are the least common in humans and are generally laboratory-acquired (2,3). AbstractDue to its potential harmful effects on the general health and reproductive life of the women, in the light of available literature, it was aimed to review the effect of human brucellosis on women's health and reproduction. Data from 75 reports belonging to the years 1917 through 2015, obtained via a search on various internet sources by the words "Brucella", "brucellosis, " "women's health, " "human pregnancy, " "human reproduction, " "abortion, " "preterm birth, " "intrauterine fetal demise, " and "intrauterine fetal death" were used to characterize basic microbiological features together with the risk factors, clinical presentations and complications of the human brucellosis related to various aspects of reproductive well-being. A high rate of spontaneous abortion was a more consistent finding rather than high rates of preterm delivery and intra...

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“…Among reported forms of transmission we found breastfeeding and more exotic forms, such as bone marrow transplantation and aerosolization of the involved bacterium . In this review, 61% of patients were infants, reported as HHT by vertical transmission or during breastfeeding . Of the 47 patients, the transplacental route ranked as the most common form of HHT (with 11 total patients).…”

Section: Discussionmentioning

confidence: 87%

Human‐to‐human transmission of Brucella – a systematic review

Tuon

Gondolfo

Cerchiari

2017

Tropical Med Int Health

136

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Abstractobjective The most common form of transmitting human brucellosis is through contaminated food or direct contact with infected animals. Human-to-human transmission (HHT) has been described as isolated case reports. The aim of this systematic review was to describe all cases of HHT of human brucellosis reported in the medical literature.methods A literature search was conducted using PubMed, Scopus and Scielo databases using specific search terms published until March 2016. Two investigators independently determined study eligibility.All clinical data were evaluated to construct a table comprising the most important clinical aspects, age, gender, confirmed infection and detection method, transmission method and HHT confirmation and potential source of infection for human transmission. No statistical method was employed in this study.results The initial search resulted in 615 publications, but only 35 were included. 45 brucellosis HHT cases were identified. 61% of patients who acquired brucellosis from another human were <1 year old (newborn and breastfeeding). Other cases include sexual transmission, blood transfusion, bone marrow transplantation and aerosol from an infected patient. Most patients (40/45) presented symptoms upon diagnosis. Diagnostic tests included culture, molecular methods and serum testing.conclusion Human brucellosis is a disease liable to transmission between humans by placental barrier, lactation, sexual and tissues such as blood and bone marrow. The indication for screening in tissue banks, transplants, blood and pregnancy is not yet established.

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Congenital brucellosis: case report

Cited by 16 publications

References 13 publications

Genitourinary brucellosis: results of a multicentric study

Genitourinary brucellosis: results of a multicentric study

The Effect of Brucellosis on Women’s Health and Reproduction

Human‐to‐human transmission of Brucella – a systematic review

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