Congenital Chagas Disease: Recommendations for Diagnosis, Treatment and Control of Newborns, Siblings and Pregnant Women

Transmisión oral de Trypanosoma cruzi: un nuevo escenario epidemiológico de la enfermedad de Chagas en Colombia y otros países suramericanos

“…Se estima una incidencia de más de 15.000 casos al año en Latinoamérica, principalmente en Argentina, Bolivia y Brasil. En Colombia, se calcula una incidencia anual de 1,04 casos de Chagas congénito por cada 1.000 nacidos (alrededor de 1.000 nuevos casos anuales) (1,13).…”

Mother-to-Child Transmission of Trypanosoma cruzi

“…In addition to vector control, early diagnosis and treatment of congenital T cruzi infection is recommended [21]. Antitrypanosomal treatment is contraindicated during pregnancy [21,22].…”

“…Antitrypanosomal treatment is contraindicated during pregnancy [21,22]. Seropositive mothers are screened during prenatal care or delivery and their offspring are diagnosed and treated.…”

“…Treatment options are limited to 2 drugs, benznidazole (BZ) and nifurtimox [21]. These drugs are well tolerated by newborns.…”

Uneventful benznidazole treatment of acute Chagas disease during pregnancy: a case report

“…Since this time, oral and congenital transmissions of CD have gained prominence 2 . Maternal infection can cause adverse effects during pregnancy relating to fetal growth and maturity, abortion, prematurity, retarded intrauterine growth, and fetal malformations 3,4 . Congenital transmission of Trypanosoma cruzi is diagnosed when a neonate is born from an infected mother with positive serology or T. cruzi parasites circulating in the blood; when T. cruzi parasites are detected in the neonate at birth or shortly thereafter, or when T. cruzi antibodies not of maternal origin are detected after birth; and when transmission to the neonate by vectors or blood transfusion has been ruled out.…”