Congenital cytomegalovirus infection: do pregnant women and healthcare providers know enough? A systematic review

Benou, Sofia; Dimitriou, Gabriel; Papaevangelou, Vassiliki; Gkentzi, Despoina

doi:10.1080/14767058.2021.1918088

Cited by 11 publications

(21 citation statements)

References 42 publications

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“…First, respondents reported that cCMV coverage in their formal training and education was minimal to non-existent. This aligns with a recent systematic review of cCMV knowledge among healthcare providers that highlighted provider lack of education and awareness as a barrier to cCMV preventative counseling (Benou et al, 2021). While many providers were aware of hand washing to prevent cCMV infection, less than half of providers spontaneously identified other measures or risk factors.…”

Section: Discussionsupporting

confidence: 76%

“…Most providers in both states reported learning about cCMV from formal medical training in settings like medical and nursing school. However, cCMV as a topic has been noted as being minimally covered in formal medical education (Benou et al, 2021). A 2022 study by Pesch and Muldoon surveyed primary care physicians and newborn hospitalists in Michigan regarding cCMV knowledge and practices.…”

Section: Discussionmentioning

confidence: 99%

“…There are several studies that have evaluated knowledge of cCMV in the U.S. Prior studies have used a variety of different sampling criteria (e.g., women of childbearing age or all women) and have shown a range of levels of awareness around cCMV (7-33%) (Benou et al, 2021;Doutré;, 2016). One of the first studies conducted in the U.S. in 2006 (Jeon et al, 2006) surveyed cCMV awareness among women of childbearing age across 7 different U.S. locations including Georgia, Alabama, Ohio, Utah, Virginia, Illinois, and Texas.…”

Section: Previous Awareness and Education Studiesmentioning

confidence: 99%

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The Role of a State Public Health Initiative in Shaping Provider Knowledge, Beliefs and Practices: A Mixed Methods Study of a Cytomegalovirus Prevention Program

2023

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To my husband Andrew and son Max, thank you for all the support along the way and keeping me from giving up. It has been one of the hardest journeys of my life and you made many sacrifices to get me here. Thanks to my parents Kurt and Leigh Anne Diekroeger for always being my biggest cheerleaders and believing in me always.Most importantly, I want to thank my inspiration for all of this, my son, my hero, Jack Feistel. You changed my life forever and I miss you every day.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Previous Awareness and Education Studiesmentioning

confidence: 99%

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The Role of a State Public Health Initiative in Shaping Provider Knowledge, Beliefs and Practices: A Mixed Methods Study of a Cytomegalovirus Prevention Program

2023

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Section: Discussionmentioning

confidence: 99%

“…While studies of cCMV knowledge and practices of obstetric providers, family medicine providers in Iran, pediatric specialists, and therapists have been conducted, this study is the first to examine cCMV knowledge, practices, and beliefs among US pediatric primary care providers and newborn hospitalists. 12,13,[16][17][18][19][20] Our findings regarding low knowledge of neonatal presentations of cCMV as well as lower levels of comfort in caring for infants with cCMV may point to opportunities for education and clarification from professional organizations. Most participants reported that the diagnosis and management were not sufficiently covered in their medical education.…”

Section: Discussionmentioning

confidence: 99%

Congenital Cytomegalovirus Knowledge, Practices, and Beliefs Among Primary Care Physicians and Newborn Hospitalists

Pesch

Muldoon

2022

J Prim Care Community Health

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Background: Congenital cytomegalovirus (cCMV) affects 1 in every 200 United States infants, at present there are 9 states which mandate newborn cCMV screening. With more infants being diagnosed, more children will need continuing care from providers who are knowledgeable about cCMV. Objectives: To examine pediatric provider knowledge, practices, and beliefs around cCMV. Methods: Primary care and newborn hospitalist pediatricians (N = 103) from Michigan, who “regularly care for infants” were invited to participate in a survey about their cCMV-related knowledge, clinical practices, and beliefs. Results: Respondents had low knowledge of typical cCMV presentation and sequelae, with mixed knowledge of screening and testing standards. Most (68%) reported rarely/never screening for cCMV, though 71% strongly agreed/agreed that primary care providers should test for cCMV. Most (90%) strongly agreed/agreed that infants who fail/refer on their newborn hearing screen should be tested for cCMV, yet 81% expressed not being comfortable diagnosing and managing cCMV. Most (72%) felt that cCMV was not sufficiently covered in their medical training; almost all respondents endorsed interest in learning more. Conclusions: Primary care and newborn hospitalists in this study expressed mixed knowledge about, infrequent practice of and low comfort with screening and caring for children with cCMV. This may present a prime opportunity for education and clinician support by professional organizations.

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Burden of sequelae and healthcare resource utilization in the first year of life in infants born with congenital cytomegalovirus (cCMV) infection in Germany: A retrospective statutory health insurance claims database analysis

de Lepper,

Stephan,

Wölle

et al. 2023

PLoS ONE

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Background Congenital cytomegalovirus (cCMV) infection can have a broad range of manifestations. This study aimed to assess cCMV-associated sequelae and healthcare resource utilization (HCRU) in infants during the first year of life in Germany. Methods A retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database was conducted. cCMV-associated sequelae and HCRU during the first year of life were assessed by matching (1:60) infants with at least one inpatient/outpatient cCMV diagnosis (ICD-10-GM: P35.1) ≤90 days after birth (cCMV90 cohort) and infants with at least one inpatient cCMV diagnosis plus specific sequelae ≤21 days after birth (cCMV21-S) to infants without cCMV or CMV (ICD-10-GM: B25) diagnosis (control group), respectively. Outcomes were analyzed during the first 365 days of life. Results Between 2014–2018, we identified 54 newborns for cCMV90 and 24 newborns for cCMV21-S cohort. Compared to the 3,240 and 1,440 controls, respectively, more cCMV90 infants (83.3% vs. 41.9%, p<0.01) presented with at least one sequela during the first year of life, including intrauterine growth retardation (42.6% vs. 5.3%, p<0.01), sensorineural hearing loss (SNHL) to deafness (38.9% vs. 2.2%, p<0.01), and motor development disorders (33.3% vs. 10.9%, p<0.01). Further, 13.0% of cCMV90 infants (vs. 2.3%, p<0.01) suffered from visual impairment. In cCMV21-S cohort, intrauterine growth retardation (79.2% vs. 6.0%, p<0.01), prematurity (54.2% vs. 7.3%, p<0.01), and motor development disorders (50.0% vs. 11.0%, p<0.01) were the most frequent sequelae. Infants in the cCMV90 and cCMV21-S cohort had, on average, 7.3 times and 9.5 times more hospitalizations and 2.0 times and 2.1 times more outpatient physician visits than their respective controls (p<0.01). Hospitalized infants with cCMV stayed, on average, significantly longer in hospital compared to their controls (cCMV90 cohort: 30.3 days vs. 9.0 days, p<0.01; cCMV21-S cohort: 46.5 days vs. 9.3 days, p<0.01). Conclusions cCMV-infection shows a considerable disease and healthcare burden during the first year of life. More than 80% of the identified newborns with cCMV suffered from at least one associated sequela during the first year of life, including long-term sequelae such as SNHL (40%) and visual impairment (13%). Additional steps for prevention of cCMV infection and associated sequelae as well as a comprehensive monitoring of disease burden are needed.

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Congenital cytomegalovirus infection: do pregnant women and healthcare providers know enough? A systematic review

Cited by 11 publications

References 42 publications

The Role of a State Public Health Initiative in Shaping Provider Knowledge, Beliefs and Practices: A Mixed Methods Study of a Cytomegalovirus Prevention Program

The Role of a State Public Health Initiative in Shaping Provider Knowledge, Beliefs and Practices: A Mixed Methods Study of a Cytomegalovirus Prevention Program

Congenital Cytomegalovirus Knowledge, Practices, and Beliefs Among Primary Care Physicians and Newborn Hospitalists

Burden of sequelae and healthcare resource utilization in the first year of life in infants born with congenital cytomegalovirus (cCMV) infection in Germany: A retrospective statutory health insurance claims database analysis

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