Congenital Disseminated Pyogenic Granuloma: Characterization of an Aggressive Multisystemic Disorder

Numerous Angiomatous Lesions in an Infant

“…1 To our knowledge, only 13 cases of CDPG are documented in medical literature. [1][2][3][4] The histopathologic findings indicative of CDPG show capillary proliferation with enlarged endothelial nuclei and highly vascular granulation tissue. Diagnosis is confirmed by positive CD31 and negative GLUT-1 and D2-40 staining.…”

“…They grow in number and size in the first few months of life and typically regress throughout infancy. 2 These PGs may form in the brain, musculoskeletal system, and visceral organs and have been associated with life-threatening hemorrhage. Additionally, PGs can be associated with transient coagulopathy, which is occasionally severe.…”

“…Additionally, PGs can be associated with transient coagulopathy, which is occasionally severe. 2 Although CDPG and multifocal infantile hemangioma (MIH) both include proliferative and involutive phases neonatally, MIH develops after the first weeks of life rather than at birth; cranial involvement is normally spared. Histopathologic findings of MIH show closely packed vascular channels lined by a single endothelial layer; immunohistochemical staining of infantile hemangioma is GLUT-1 is positive, whereas in CDPG, GLUT-1 is negative.…”

What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth

“…Congenital disseminated pyogenic granuloma is a distinctive, multisystemic aggressive disorder that primarily affects the skin, brain, visceral organs, and musculoskeletal system [35].…”

Nodule on the hand of a 13‐year‐old girl

“…ing congenital disseminated disease with multiorgan involvement. 5 In children, agminated LH have been seen arising from capillary malformations and congenital hemangioma. 6 LH may involve the oral mucosa, particularly the gingiva, in both adults and children.…”