Congenital epulis: its natural history.

O'Brian, F V; Pielou, W D

doi:10.1136/adc.46.248.559

Cited by 39 publications

(20 citation statements)

References 5 publications

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“…There are no reports in the literature to suggest that CGCEs increase in size after birth [2,36]. Furthermore, there is reported evidence that small lesions regressed during the first year of life [36][37][38][39]. Another point of interest is that there are no reports of recurrence of a CGCE in spite of an incomplete excision [4,36].…”

Section: Discussionmentioning

confidence: 82%

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Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth. Histomorphologically, it resembles a granular cell tumor (GCT) of the adult. The histogenesis of this lesion is unclear. We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells. The resultant immunohistochemical profile showed positivity of these cells to vimentin, NKI/C3, and PGP9.5. This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature. In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-alpha, which further contributes to the distinction between a CGCE and the adult GCT.

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Section: Discussionmentioning

confidence: 82%

“…The lesion grows only during the intrauterine period and ceases to grow at birth [34,35]. There are no reports in the literature to suggest that CGCEs increase in size after birth [2,36]. Furthermore, there is reported evidence that small lesions regressed during the first year of life [36][37][38][39].…”

Section: Discussionmentioning

confidence: 90%

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

2009

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“…Although histologically benign, clinically significant problems like polyhydramnios, neonatal respiratory distress and feeding difficulties have been reported (Lack et al, 1981;Ophir and Marshak, 1985). Postnatal tumour growth does not occur and a few cases of spontaneous tumour regression have been described (Jenkins and Hill, 1968;O'Brien and Pielou, 1971;Cussen and McMahon, 1975). Prompt surgical removal, however, has proven to be an effective treatment, with few complications and no recurrences, even when the excision was incomplete (Lack et al, 1981;Zuker and Buenechea, 1993).…”

Section: Discussionmentioning

confidence: 94%

Prenatal ultrasound detection of a congenital epulis in a triple X female fetus: a case report

Kim

Gross

1999

Prenat. Diagn.

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A case of congenital epulis in a triple X infant, whose intra‐oral mass was first detected on a 33‐week prenatal ultrasound, is described. Two previous ultrasound studies performed at 21 and 28 weeks' gestation showed normal facial anatomy, suggesting accelerated tumour growth during the third trimester. Genetic amniocentesis also showed the infant to possess a 47, XXX karyotype. Copyright © 1999 John Wiley & Sons, Ltd.

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“…Simple comparison of these indices is difficult, but considering the high cell activity in infants, the proliferative activity in our patient may not have been high. Cases in which size reduction and disappearance of lesions within 1 year of course observation have also been reported [15][16][17]. Moreover, the size has varied from several mm to 9 cm in reported cases [18][19][20], and large lesions in the anterior tooth region have been reported, although these may have been due to the influence of mechanical stimulation.…”

Section: Discussionmentioning

confidence: 96%

A Case of Congenital Granular Cell Epulis in the Maxillary Anterior Ridge: A Study of Cell Proliferation Using Immunohistological Staining

Kato

Nomura

Matsumura

et al. 2011

J. Maxillofac. Oral Surg.

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Congenital granular cell epulis (CGCE) is a very rare benign tumor that preferentially develops in female infants. The histopathological characteristics of CGCE are very similar to a granular cell tumor, but the histological genesis is unknown. We report a case of a fourday-old female neonate who had a tumor mass in the region of the left maxillary anterior teeth. The rate of cell proliferation was determined by immunostaining with Ki-67 and PCNA, which showed labeling indexes of 16.7 and 15.1%, respectively.

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Congenital epulis: its natural history.

Cited by 39 publications

References 5 publications

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult

Prenatal ultrasound detection of a congenital epulis in a triple X female fetus: a case report

A Case of Congenital Granular Cell Epulis in the Maxillary Anterior Ridge: A Study of Cell Proliferation Using Immunohistological Staining

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