Congenital granular cell lesion of the tongue: a report of two cases and review of the literature

Yancoskie, Aaron E.; Reebye, Uday N.; Segal, Joshua; Barrios, B.; Velasco, A; Fantasia, John E

doi:10.1016/j.oooo.2015.10.013

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The exact aetiology and pathogenesis of this tumour remain unknown; however, the predominant hypothesis suggests that lesional cells are undifferentiated mesenchymal cells that fail to undergo involution during early development 9. Immunohistochemical profiling is used to identify the origin of the CGCL.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical profiling is used to identify the origin of the CGCL. A review of the literature revealed that immunohistochemistry was reported in eight cases of CGCL of the tongue with negative results for S-100 9–13. S-100 proteins are normally present in cells derived from the neural crest, such as Schwann cells and melanocytes, which possibly excludes a neurogenic aetiology for CGCL.…”

Section: Discussionmentioning

confidence: 99%

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Newborn with a rare congenital granular cell lesion of the tongue

Kaminecki

Wang

Abbas³

et al. 2018

BMJ Case Rep

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Congenital granular cell lesion (CGCL) is an uncommon, benign soft tissue lesion that usually arises from the alveolar mucosa of neonates. The present report describes a case of CGCL originating from the tongue of a newborn female infant. The lesion was negative for S-100 differentiating it from congenital granular cell tumour. The lesion was excised under local anaesthesia with no recurrence at 4 months.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%