Congenital granular-cell tumor of the gingiva

Abstract

Congenital granular cell tumors of the gingiva (synonyms: congenital myoblastoma, congenital epulis) originate from the alveolar ridge in newborns. They are rare granular-cell tumors with benign histology. The main differential diagnosis is epignathus (oral teratoma). Early surgical excision is recommended due to a risk of airway obstruction and difficulty feeding.

Obstructive congenital gingival granular cell tumour

“…3 Normal surface epithelium and cells with large, eosinophilic, granular cytoplasm and small nuclei (HE Â 100). teratomas originating from oropharynx [17]. Epignathus also carry a risk of airway obstruction.…”

“…Although its indolent nature CGCT can be sufficiently large or multiple [8]. In the case of feeding problems with a risk of aspiration pneumonia, respiratory obstruction, bleeding problems due to external trauma requires early surgical removal [2,9,17]. Neither recurrence nor malignancy has been reported, even after incomplete excision [10].…”

Prenatal diagnosis of congenital epulis:a case report

“…The origin of congenital GCT is still controversial. Most congenital GCTs have been shown to be S-100 and NSE negative, and considered not to be of Schwann-cell origin 2,4,[8][9][10] . However, in our case the tumor stain was positive for S-100 but negative for NSE.…”

Prenatal diagnosis and multidisciplinary approach to the congenital gingival granular cell tumor

“…Malignant degeneration of the lesion throughout the years have not been described [21], whereas some spontaneous regressions have been mentioned [4]. Nevertheless, the presence of large lesions determining feeding impairment risk of ab ingestis, respiratory obstruction, or bleeding from external trauma leads to mandatory surgical excision [6,8,21].…”

“…Nevertheless, the presence of large lesions determining feeding impairment risk of ab ingestis, respiratory obstruction, or bleeding from external trauma leads to mandatory surgical excision [6,8,21].…”