Congenital infiltrating lipomatosis of the face: A case report with review of literature

Abstract

Congenital infiltrating lipomatosis of the face (CIL-F) has been described as a disorder in which mature lipocytes invade adjacent tissues in the facial region. Its etiology and pathogenesis is unknown. The tumor is congenital in origin and occurs in infancy or early childhood. It is unencapsulated and characterized by diffuse infiltration of mature adipose tissue over normal muscle fibers, rapid growth, associated osseous hyperplasia, and a high recurrence rate postsurgical intervention. Due to its diffuse infiltration and involvement of important facial structures, complete surgical excision is often impossible. CIL-F is rare and there are only a few cases reported in the available literature. We present the case of a 17-year-old female, who reported with the complaint of recurrent unilateral facial swelling, with a history of two previous resections.

Heterogeneity of adipose tissue in development and metabolic function

“…Rare forms of human WAT dystrophies, such as Köbberling-Dunnigan syndrome (Anderson et al, 1999;Jackson et al, 1998;Peters et al, 1998) and congenital infiltrating lipomatosis of the face (D'Souza et al, 2014;Padwa and Mulliken, 2001;Urs et al, 2013), suggest different origins for subcutaneous adipocytes in the lower versus upper body part (Lemos et al, 2012;Sanchez-Gurmaches and Guertin, 2014a). To this end, lineage tracing by expressing the Cre protein (which causes DNA recombination) under the control of the neural crest marker Sox10 (SRY-related HMGbox 10) showed that adipocytes in the head and neck, but not trunk pgWAT and SAT, develop from the neuroectoderm (Billon et al, 2007).…”

Immediate Placement and Provisionalization of Maxillary Incisors Implants in an Adolescent Patient: A Case Report

“…Facial infiltrating lipomatosis (FIL) is a distinct and rare clinical entity with less than fifty reported cases [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Slavin, et al in 1983 described the typical histopathological features and named the disease as congenital infiltrating lipomatosis of the face [18,19].…”