Congenital Intracranial Mesenchymal Chondrosarcoma: Case Report and Review of the Literature in Pediatric Patients

Cecio, Rossella De; Migliaccio, Ilenia; Falleti, Jessica; De, Marialaura Del Basso; Pettinato, Guido

doi:10.2350/07-05-0279.1

Cited by 19 publications

(3 citation statements)

References 35 publications

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“…Our data showed a further lower 5-year OS of 49.4%. Notably, up to 7 (6.7%) cases [12,16,5,15,2,20] died within 1 months, and 4 (3.9%) [12,16,5] of them died within 10 days in the pooled cohort.…”

Section: Discussionmentioning

confidence: 92%

Active Treatment Strategy Improves Overall Survival of Patients With Intracranial Mesenchymal Chondrosarcoma After Surgical Treatment

Chen¹,

Chen²,

Hu³

et al. 2021

Preprint

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Intracranial mesenchymal chondrosarcoma (IMC) is a rare malignancy. We aimed to investigate the efficacy of treatment in overall survival (OS) for patients with IMC. Firstly, we retrospectively collected 9 cases from two medical centers, then screened the publications and enrolled 112 reported cases, and finally pooled these data together to analyze candidate prognostic factors for OS. For the treatment-related predictors, we defined active intervention if GTR (gross total resection) and/or radiotherapy (GaoR) was employed and inactive one when neither GTR nor radiotherapy (NGnR) was used. The 1-year, 3-year and 5-year OS for patients with IMC were 82.6%, 60.3% and 49.4%, respectively. NGnR was the independent risk factor for OS (HR [hazard ratio] = 4.70, 95% CI [confidence interval] 1.575 ~ 14.060; p = 0.006). The 1-year, 3-year and 5-year of patients with GaoR were higher than that of patients with NGnR (85.1%, 68.7% and 57.7% vs. 72.7%, 42.4% and 21.2%). Patients with IMC could obtain survival benefit from active intervention (GaoR group). GTR and/or radiotherapy should be recommended whenever feasible.

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Section: Discussionmentioning

confidence: 92%

Active Treatment Strategy Improves Overall Survival of Patients With Intracranial Mesenchymal Chondrosarcoma After Surgical Treatment

Chen¹,

Chen²,

Hu³

et al. 2021

Preprint

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show abstract

“…However, this was not evident in our three cases, where our patients were all males; and were in the pediatric age group (Table 1). Congenital MCS has been reported in two studies, one of which was orbital 8, 9. On the other hand, the neoplasm has been reported in an 84-year-old lady by Shimo-Oku in 1980 10 .…”

Section: Discussionmentioning

confidence: 97%

Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases

Alkatan

Eberhart

Alshomar

et al. 2018

Saudi Journal of Ophthalmology

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Mesenchymal chondrosarcoma (MCS) is an unusual tumor mainly found in the skeleton. Around third of the cases occur in extra-skeletal sites with the orbit being the third most common site in these cases. In previous reviews of the orbital cases, it has been concluded that orbital MCS tends to occur in women in the second or third decades of life. However, 8 cases of orbital MCS have been reported so far in the pediatric age group (age less than 18 years-old) one of which has been considered congenital MCS in a 5-days old newborn girl. We describe 3 additional pediatric cases with primary orbital MCS and they were all males. Our cases presented with proptosis and calcific orbital masses on imaging studies. Histopathological examination of the excised masses shared the typical presence of undifferentiated mesenchymal cells and immature areas of cartilage. The diagnosis of MCS was further confirmed by immunohistochemical staining. Brief review of the literature in relation to this diagnosis in the orbit is also presented.

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“…In the pediatric age group, parenchymal lesions such as supratentorial primitive neuroectodermal tumor, high-grade non-Hodgkin's lymphoma, malignant hemangiopericytoma, or lesions originating from the base of the skull, such as chondrosarcoma at the skull base, embryonal rhabdomyosarcoma, or small cell osteosarcoma, should be the other differentials. [11][12][13][14][15] That is why, IHC is important to distinguish between those diagnoses, but no proper Immunohistochemistry (IHC) patterns have been identified till now, which is characteristic of IEMC. However, it is almost always positive for vimentin and S-100 and negative for synaptophysin, chromogranin, and EMA, but occasionally positive for GFAP (25% of the time).…”

Section: Tumor Characteristics and Presentationmentioning

confidence: 99%

Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma of the Brain in a Pediatric Patient: A Case Report and Review of Literature

Sikdar,

Gupta,

Roshan

et al. 2023

Indian J Med Paediatr Oncol

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Intracranial extraskeletal mesenchymal chondrosarcoma, which is characterized by undifferentiated mesenchymal cells in the presence of occasional pockets of mature hyaline cartilage, is rare in our clinical practice and commonly seen in young adults. In the pediatric population, only a few cases have been reported. In this article, we describe a case of primary recurrent intracranial mesenchymal chondrosarcoma in an 11-year-old boy well treated by surgery, radiation, and chemotherapy. We also reviewed all previously published reports on pediatric patients on the basis of their manifestations and management.

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Congenital Intracranial Mesenchymal Chondrosarcoma: Case Report and Review of the Literature in Pediatric Patients

Cited by 19 publications

References 35 publications

Active Treatment Strategy Improves Overall Survival of Patients With Intracranial Mesenchymal Chondrosarcoma After Surgical Treatment

Active Treatment Strategy Improves Overall Survival of Patients With Intracranial Mesenchymal Chondrosarcoma After Surgical Treatment

Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases

Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma of the Brain in a Pediatric Patient: A Case Report and Review of Literature

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