Congenital malaria due to Plasmodium vivax: a case report from Sri Lanka

Silva, D.H.G. De; Mendis, Kamini; Premaratne, U. N.; Jayatilleke, Sarojini M.D.; Soyza, Priyani E.

doi:10.1016/0035-9203(82)90011-6

Cited by 28 publications

(23 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The postulated mechanisms for congenital transmission according to an earlier report include maternal transfusion into the fetal circulation either at the time of delivery or during pregnancy, through direct penetration through the chorionic villi, or through premature separation of the placenta (De Silva et al 1982). However, the effectiveness of the placenta to restrain malaria parasite passage to the fetus and the remarkable capacity of the fetus to resist infection was demonstrated (Miller and Telford 1996).…”

Section: Discussionmentioning

confidence: 99%

Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?

Uneke

2007

Parasitol Res

View full text Add to dashboard Cite

It is still debatable whether congenital Plasmodium falciparum malaria is a rarity or a frequent occurrence in sub-Saharan Africa. The objective of this report is to review scientific information and findings from investigations conducted in sub-Saharan Africa on the occurrence of congenital malaria to highlight the need for development of appropriate public health policy on prevention, care, treatment, and support activities. Studies conducted in sub-Saharan Africa within the last two decades (1986 to 2006) that investigated congenital or transplacental malaria were identified using the Medline-Entrez Pubmed search and systematically reviewed. References from selected publications obtained from a Google search were also used to identify additional relevant literature for the review. Five of the studies reviewed indicated that congenital malaria is a rare event in sub-Saharan Africa with prevalence ranging from 0% to 0.7% although maternal malaria parasitemia rates of between 24.8 and 54.4% were obtained. Nine other studies noted that congenital malaria was not uncommon, with prevalence reaching up to 37%. These studies also noted high frequency of neonatal peripheral parasitemia ranging from 4.0 to 46.7%. Congenital malaria should be suspected and investigated in babies whose mothers are parasitemic, particularly if the babies are febrile.

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?

Uneke

2007

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…Neonatal malaria was once thought to be rare, especially in malaria holo-endemic areas [3]. This was thought to be due to the protective effect of maternal antibodies that are passed to the newborn [4][5][6]and to the protective role of fetal hemoglobin in slowing the rate of the parasite development [7].…”

Section: Introductionmentioning

confidence: 99%

Plasmodium falciparum infection among neonates in the North Central Region of Nigeria

Okoli

Okolo

Collins

2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: This cross-sectional study investigated the rate of congenital and neonatal malaria infections in patients attending our hospital. Methodology: Thick and thin blood films of 288 neonates admitted in the Special Care Baby Unit of Jos University Teaching Hospital, Nigeria, were examined microscopically for malaria parasites. Babies' and mothers' demographic and clinical data were analyzed. Results: Of 288 blood samples examined, 160 (55.6%) were from males, 115 (39.9%) were from babies 0 to 7 days old, and 173 (60.1%) were from babies 8 to 28 days old. In total, 91 (31.6%) babies had malaria parasitaemia, of whom 49 (53.8%) were males. Malaria was significantly higher in babies 8 to 28 days old (p<0.001) and was independent of gender (p=0.692). Prevalence rates for congenital and neonatal malaria were 6.9% and 24.7% respectively. Clinical presentations on admission included fever, cough, pallor, jaundice, and inability to suck. A total of 145 (50.3%) babies had symptoms of malaria, of whom 56 (61.5%) had malaria parasitaemia. Symptoms of malaria were present in 35 (12.2%) babies of 59 (20.5%) mothers who had symptoms of malaria during pregnancy. Ten (11.0%) of these neonates had malaria parasitaemia, of whom 4 (0.4%) were 0 to -7days old. Plasmodium falciparum was the only specie identified. No mortality was recorded against malaria-infected babies. Conclusion: High prevalence of malaria in these neonates calls for high index of suspicion. Inclusion of malaria parasite test in the routine battery of tests for babies presenting with clinical signs and symptoms of neonatal infections is recommended.

show abstract

“…The great majority of malaria cases in the world occur in tropical Africa where the disease is esti mated to cause 0.5-1 million deaths per year [2], In Mozambique malaria constitutes one of the principal health problems. In 1975/1976 malaria prevalence was over 40%, but the situation has worsened due to the appearance of chloroquine resistance [3], One serious consequence of this is the deterioration of maternal and child health [1], Pregnant women are more affected by malaria than non-pregnant women both in types with few symptoms [4] and in types with more acute symptoms [5], The situation might be worsened by inadequate therapy and by a diminishing protective immunity [6,7], In many cases malaria is complicated by a serious maternal anaemia, above all in the second trimester [5,8], Malarial complications of the fetus comprise fetal loss and prema turity [4], retarded intra-uterine growth [9,10], decreased passage of IgG [7,9] and congenital malaria [ 1,[11][12][13][14][15], Placental malaria is described in the literature as an entity associated with an increase in placental surface parasitaemia [13] with associated tissular changes in the blood cell membrane and in the trophoblastic cells [9], There seems to be auto-agglutination and fibrine aggrega tion in the intervillous space with deposition of malarial pigment and mononuclear cell infiltration [16],…”

Section: Introductionmentioning

confidence: 99%

Materno-Fetal Transmission of Pregnancy Malaria: An Immunoparasitological Study on 202 Parturients in Maputo

Bergström¹,

Fernandes

Schwalbach

et al. 1993

Gynecol Obstet Invest

View full text Add to dashboard Cite

A total of 202 delivering mothers and their newborns were studied with the intention to follow the materno-fetal transmission of malaria. Malaria infection was encountered in 35 cases (17.3%) in which Plasmodium falciparum predominated in peripheral blood while P. malariae predominated on the placental surface. In cord blood P. falciparum was encountered in 1.5% of the cases. There was slightly more maternal infection in rural (23 %) than in suburban areas (19%). Less malaria infection was encountered in primiparas than in multiparas and there was similar antibody response in both mothers and their newborns. Anaemia was encountered in 70% of the mothers and in 93% of the newborns. There was no significant correlation between low birth weight of the newborn and malaria parasitaemia in the mother.

show abstract

Congenital malaria due to Plasmodium vivax: a case report from Sri Lanka

Cited by 28 publications

References 3 publications

Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?

Congenital Plasmodium falciparum malaria in sub-Saharan Africa: a rarity or frequent occurrence?

Plasmodium falciparum infection among neonates in the North Central Region of Nigeria

Materno-Fetal Transmission of Pregnancy Malaria: An Immunoparasitological Study on 202 Parturients in Maputo

Contact Info

Product

Resources

About