Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI

Korostyshevskaya, A. M.; Савелов, А. А.; Папуша, Людмила Ивановна; Druy, Alexander; Yarnykh, Vasily L.

doi:10.1016/j.clinimag.2018.06.001

Cited by 26 publications

(38 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A newer quantitative MRI method, fast macromolecular proton fraction (MPF) mapping, has been recently adapted to fetal brain applications . MPF has been histologically validated as a myelin biomarker in animal models and has shown the capability to quantify myelin damage in clinical studies of multiple sclerosis and mild traumatic brain injury .…”

mentioning

confidence: 99%

“…In the recent normal fetal and pediatric brain studies, MPF maps demonstrated close quantitative agreement with spatiotemporal trajectories of myelin development. MPF mapping also shown promise as a complementary technique for evaluation of fetal brain tumors . A practically useful feature of the fast MPF mapping method is the feasibility of implementation on clinical MRI scanners with acceptable scan times …”

mentioning

confidence: 99%

“…16,17 A newer quantitative MRI method, fast macromolecular proton fraction (MPF) mapping, 18,19 has been recently adapted to fetal brain applications. 20,21 MPF has been histologically validated as a myelin biomarker in animal models [22][23][24][25] and has shown the capability to quantify myelin damage in clinical studies of multiple sclerosis 26,27 and mild traumatic brain injury. 28 In the recent normal fetal 20 and pediatric 29 brain studies, MPF maps demonstrated close quantitative agreement with spatiotemporal trajectories of myelin development.…”

mentioning

confidence: 99%

“…MPF mapping also shown promise as a complementary technique for evaluation of fetal brain tumors. 21 A practically useful feature of the fast MPF mapping method 18,19 is the feasibility of implementation on clinical MRI scanners with acceptable scan times. 20,21,29 While both DWI and fast MPF mapping reflect tissue changes in the course of brain maturation, they are driven by different biophysical mechanisms.…”

mentioning

confidence: 99%

“…21 A practically useful feature of the fast MPF mapping method 18,19 is the feasibility of implementation on clinical MRI scanners with acceptable scan times. 20,21,29 While both DWI and fast MPF mapping reflect tissue changes in the course of brain maturation, they are driven by different biophysical mechanisms. ADC describes mobility of water molecules and is affected by the factors restricting molecular motion, including primarily the amount of cell membranes in the tissue volume and concentration of biological macromolecules.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation

Korostyshevskaya

Prihod'ko

Савелов

et al. 2019

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Background: Apparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI. Purpose: To compare the capability of ADC and MPF to quantify the normal fetal brain development. Study Type: Prospective. Population: 42 human fetuses in utero (gestational age (GA) = 27.7 ± 6.0, range 20–38 weeks). Field Strength/Sequence: 1.5T; diffusion-weighted single-shot echo-planar spin-echo with five b-values for ADC mapping; spoiled multi-shot echo-planar gradient-echo with T1, proton density, and magnetization transfer contrast weightings for single-point MPF mapping. Assessment: Two operators measured ADC and MPF in the medulla, pons, cerebellum, thalamus, and frontal, occipital, and temporal cerebral white matter (WM). Statistical Tests: Mixed repeated-measures ANOVA with the factors of pregnancy trimester and brain structure; Pearson correlation coefficient (r); Hotelling-Williams test to compare strengths of correlations. Results: From 2nd to 3rd trimester, ADC significantly decreased in the thalamus and cerebellum (P<0.005). MPF significantly increased in the medulla, pons, thalamus, and cerebellum (P<0.005). Cerebral WM had significantly higher ADC and lower MPF compared to the medulla and pons in both trimesters. MPF (r range 0.83− 0.89, P<0.001) and ADC (r range −0.43 −0.75, P≤0.004) significantly correlated with GA and each other (r range −0.32 −0.60, P≤0.04) in the medulla, pons, thalamus, and cerebellum. No significant correlations and distinctions between regions and trimesters were observed for cerebral WM (P range 0.1–0.75). Correlations with GA were significantly stronger for MPF compared to ADC in the medulla, pons, and cerebellum (Hotelling-Williams test P<0.003) and similar in the thalamus. Structure-averaged MPF and ADC values strongly correlated (r=0.95, P<0.001). Data Conclusion: MPF and ADC demonstrated qualitatively similar but quantitatively different spatiotemporal patterns. MPF appeared more sensitive to changes in the brain structures with prenatal onset of myelination.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation

Korostyshevskaya

Prihod'ko

Савелов

et al. 2019

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

Prenatally detected congenital medulloblastoma

Moradi

Hamidian²,

Soltanghoraee

et al. 2022

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

Scan–Rescan Repeatability and Impact of B₀ and B₁ Field Nonuniformity Corrections in Single‐Point Whole‐Brain Macromolecular Proton Fraction Mapping

Yarnykh

Kisel

Khodanovich

2019

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Background: Single-point macromolecular proton fraction (MPF) mapping is a recent quantitative MRI method for fast assessment of brain myelination. Information about reproducibility and sensitivity of MPF mapping to magnetic field non-uniformity is important for clinical applications.Purpose: To assess scan-rescan repeatability and a value of B 0 and B 1 field inhomogeneity corrections in single-point synthetic-reference MPF mapping.Study Type: Prospective.Population: 8 healthy adult volunteers underwent two scans with 11.5±2.3 months interval.Field Strength/Sequence: 3T; whole-brain 3D MPF mapping protocol included three spoiled gradient-echo sequences providing T 1 , proton density, and magnetization transfer contrasts with 1.25×1.25×1.25 mm 3 resolution and B 0 and B 1 mapping sequences.Assessment: MPF maps were reconstructed with B 0 and B 1 field non-uniformity correction, B 0 and B 1 only corrections, and without corrections. Mean MPF values were measured in automatically segmented white matter (WM) and gray matter (GM).Statistical Tests: Within-subject coefficient of variation (CV), intraclass correlation coefficient (ICC), Bland-Altman plots, and paired t-tests to assess scan-rescan repeatability. Repeatedmeasures ANOVA to compare field corrections.Results: Maximal relative local MPF errors without correction in the areas of largest field nonuniformities were about 5% and 27% for B 0 and B 1 , respectively. Effect of B 0 correction was insignificant for whole-brain WM (P>0.25) and GM (P>0.98) MPF. The absence of B 1 correction caused a positive relative bias of 4-5% (P<0.001) in both tissues. Scan-rescan agreement was similar for all field correction options with ICCs 0.80-0.81 for WM and 0.89-0.92 for GM. CVs were 1.6-1.7% for WM and 0.7-1.0% for GM.

show abstract

Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI

Cited by 26 publications

References 18 publications

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation

Prenatally detected congenital medulloblastoma

Scan–Rescan Repeatability and Impact of B₀ and B₁ Field Nonuniformity Corrections in Single‐Point Whole‐Brain Macromolecular Proton Fraction Mapping

Contact Info

Product

Resources

About

Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI

Cited by 26 publications

References 18 publications

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation

Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation

Prenatally detected congenital medulloblastoma

Scan–Rescan Repeatability and Impact of B0 and B1 Field Nonuniformity Corrections in Single‐Point Whole‐Brain Macromolecular Proton Fraction Mapping

Contact Info

Product

Resources

About

Scan–Rescan Repeatability and Impact of B₀ and B₁ Field Nonuniformity Corrections in Single‐Point Whole‐Brain Macromolecular Proton Fraction Mapping