Congenital Microcystic Adnexal Carcinoma

Fu, Teresa; Clark, F. Landon; Lorenz, H. Peter; Bruckner, Anna L.

doi:10.1001/archdermatol.2010.440

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…MAC could therefore be arising in children but be unrecognized until adulthood if patients overlook the lesion when it is slow growing and asymptomatic. Ten cases of MAC have previously been reported in children younger than 18 years of age, two of which were congenital (Table ) . There has also been MAC reported in two siblings, suggesting a genetic basis for this tumor or a common exposure history .…”

Section: Discussionmentioning

confidence: 95%

Microcystic Adnexal Carcinoma in the Axilla of an 18‐Year‐Old Woman

Green

Mitchum

Marquart

et al. 2014

Pediatric Dermatology

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Microcystic adnexal carcinoma (MAC) is an uncommon adnexal neoplasm with a predilection for the head and neck. The tumor rarely metastasizes but is locally aggressive and commonly demonstrates perineural invasion. MAC occurs most often in older adults. This report describes a young woman with a MAC in her left axilla who required two stages of Mohs micrographic surgery followed by a wide local excision because of persistent perineural invasion in close proximity to the brachial plexus. Other cases presenting in the pediatric age group are discussed.

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Section: Discussionmentioning

confidence: 95%

Microcystic Adnexal Carcinoma in the Axilla of an 18‐Year‐Old Woman

Green

Mitchum

Marquart

et al. 2014

Pediatric Dermatology

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“…71 MAC is exceptionally rare in children; there have only been 2 congenital cases reported. 54,82 This literature review demonstrates that the patients with periocular MAC have similar demographic characteristics to the nonperiocular counterpart.…”

Section: Epidemiology and Clinical Presentationmentioning

confidence: 87%

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Cheung

Rabinowitz

Tuluc

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe a patient with periocular microcystic adnexal carcinoma (MAC) and to review the clinical presentation, systemic work-up, histopathologic features, and outcome of all previously reported periocular MAC. Methods: A major literature review. PubMed/MEDLINE and Google Scholar databases were searched for all well-documented cases of periocular MAC. Results: The final analysis yielded 93 patients with MAC, 48 (52%) females, 39 (42%) males, and 6 with sex not specified (6%) with an average age of 56 years (range 3 days–95 years). Most tumors were localized to the eyebrow (26/93, 28%) and lower eyelid (20/93, 22%). Of patients with known information, MAC most commonly presented as a nodule (37/68, 54%) or plaque (20/68, 29%) with poorly-defined margins (20/51, 39%) and distortion of eyelid margin (13/51, 25%). Orbital involvement at any point of the disease course was seen in 20 of 93 (22%) patients. An accurate histopathologic diagnosis on initial biopsy was made in 25 of 70 (36%) cases. Initial management included surgical excision (47/93, 51%), Mohs micrographic surgery (17/93, 18%), and excision with frozen section control of margins (8/93, 9%). Aggressive or recurrent MAC was managed with multimodal therapies, including adjuvant radiation (10/34, 29%). The average follow-up after the last treatment was 3 years (median 2, range 0.2–20 years). In total, 33 of 86 (38%) tumors recurred, and 6 of 87 (7%) metastasized. Disease-related mortality occurred in 3 of 79 (4%) of patients. Conclusions: Periocular MAC is frequently misdiagnosed on initial biopsy and has a tendency for recurrence and locally aggressive behavior, highlighting the importance of accurate timely diagnosis, and appropriate management.

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“…Microcystic adnexal carcinoma (MAC) is a rare neoplasm often presenting as a scar‐like papule with predilection for the head and neck and an average reported age of 62 years . This entity is exceedingly rare in the pediatric population, with a total of only 11 published reports on a recent review, including two congenital cases . We have presented what we believe to be the youngest noncongenital case of a patient with longstand‐ing, ulcerated microcystic adnexal carcinoma.…”

Section: Discussionmentioning

confidence: 99%