The present article provides an overview of the anesthetic pr ocedure employed during off-pump aortic arch interruption surger y, a cardiovascular operation. The case study involved a 54-year-o ld male patient who was diagnosed with aortic arch interruption and who underwent an off-pump surgical intervention. Anesthesia protocol: The patient fasted and abstained before surgery. In the operating room, anesthesia induction was achieve d using midazolam, esketamine, etomidate, sufentanil, and rocuro nium. Throughout the procedure, anesthesia was maintained using propofol, remifentanil, and sevoflurane, with dosage adjustments made in accordance with the progress of the surgical interventio n. Intraoperative monitoring: Conventional monitoring included E CG, blood pressure, pulse oxygen saturation, end-tidal CO2, bispec tral index, hemodynamic monitoring, and cerebral oxygen saturati on monitoring (rSO2). The patient's mean arterial pressure (MAP) was carefully regulated within the range of 60-80 mmHg, while t he heart rate was maintained between 50-90 beats per minute t o ensure a stable circulatory state. Anesthesia outcome: The patient's vital signs remained stable, with appropriate anesthesia depth. The surgery was successfully completed, and the patient was transferred to the critical care u nit for postoperative observation and treatment. In off-pump aortic arch interruption surgery, maintaining stabl e vital signs and ensuring stable circulation are crucial anesthetic management components. The reported case demonstrated a satis factory anesthesia effect with no significant complications. This ca se highlights the importance of employing reasonable anesthesia methods and monitoring measures for safe and effective patient care.