Congenital Palatal Ulcers in Newborn Infants with Cleft Lip and Palate: Diagnosis, Frequency, and Significance

Bacher, M.; Göz, Gernot; Pham, Thinh Quy Duc; Ney, Thomas; Ehrenfeld, Michael

doi:10.1597/1545-1569_1996_033_0037_cpuini_2.3.co_2

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…Considering the abnormal anatomical confi guration of cleft soft palate, persistent mechanical stress may propose a stimulation for subsequent soft tissue infl ammation. Th e observance of palatal ulceration in CLP aff ected infants through tongue motor activity largely supports this hypothesis [32]. An isolated report on the histological evaluation of cleft palate demonstrated similar fi ndings of infl ammatory infi ltrate congruent to our observation [33].…”

Section: Discussionsupporting

confidence: 88%

Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate

Tellermann

Reiser

Pilmane

2019

PoA

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Introduction. Midline orofacial defects bear a high degree of morbidity for the affected individual, often associated with retardation in neonatal development and the need for surgical intervention. The etiology of the deformities, despite their high prevalence, remains, however, largely unknown. We report on the evaluation and quantification of proliferative and inflammatory markers in the cleft affected soft palate. Material and methods. This study included soft palate samples of eight cleft lip and palate affected individuals and a control group of six soft tissue specimens obtained during correctional surgery of hyperdentia. All samples were processed via immunohistochemistry for marker EGFR, NF-κB, Ki-67, Ma-1. The results were evaluated semi-quantitatively and statistically analysed by IBM SPSS 25.0. Results. Histopathological signs of inflammatory changes were continuous in cleft affected specimen. The quantitative distribution of the markers in the cleft affected group displayed a significant correlation between EGFR, Ki-67 and NF-κB (p< 0.05), along with a correlation among Ki-67 and NF-κB (p< 0.05). Immunoreactive structures in control group showed lower numbers in all evaluated specimen. A statistical significance between cleft affected and non-cleft tissue was observed in EGFR and Ma-1 (p< 0.05). Conclusion. Results are suggestive of a tissue phenotype modification in cleft affected palate. Observation of distribution and statistical correlation hint towards the involvement of epithelial growth inducer EGFR and inflammatory/ proliferative marker in epithelial changes.

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Section: Discussionsupporting

confidence: 88%

Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate

Tellermann

Reiser

Pilmane

2019

PoA

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“…Increased TNF-α and IL-12 CL connective tissue response may indicate a linkage and common function in the development of the local tissue immunity. Reports on the increased incidence of mucosal ulceration, gingivitis, caries and a general poor oral health in the cleft affected [45,46] gives reason to assume that the cleft pathology exposes its carrier in a higher degree to chronic inflammatory diseases of the oral mucosal lining. This assumption aligns with our findings of marked elevated TNF-α levels in the cleft group over the healthy comparison group.…”

Section: Discussionmentioning

confidence: 99%

Profiling and Characterization of Localized Cytokine Response in Congenital Cleft Affected Lip Tissue

Reiser

Tellermann

Akota

et al. 2021

Life

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(1) Background: Despite cleft lips and palates belonging to the most common orofacial congenital anomalies, their morphopathogenesis is not yet fully understood. The study aimed to determine the distribution and relation of cytokines interferon-γ (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-2, IL-7, IL-12, and IL-13 in the cleft affected mucosa of the lip. (2) Materials and Methods: Twenty cleft lip (CL) mucosal samples and seven control tissues of oral cavity mucosa were included in the study. Specimen were obtained during reconstruction surgeries and processed by hematoxylin and eosin staining and immunohistochemistry for IFN-γ, TNF-α, IL-2, IL-7, IL-12, and IL-13. (3) Results: The distribution of cytokines was higher overall in the cleft affected epithelium compared to the connective tissue, with TNF-a, IL-2, and IL-12 displaying the highest number of immunopositive cells. With the exception of IL-2, CL specimen showed higher immunoreactivity. IFN-γ displayed only minor immunoreactivity, with no expression in the control epithelium. Correlation analysis was strongest between CL epithelial IL-13 and IFN-γ (z = 0.71, p < 0.0001). (4) Conclusions: The CLP affected epithelium displays high degrees of plasticity in expressing different cytokines, pointing towards the stimulation of a local adaptive immune response based on consistent inflammatory processes.

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Introduction to clinical provision of nasoalveolar molding

Shetye¹,

Gibson²

2022

Cleft and Craniofacial Orthodontics

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Congenital Palatal Ulcers in Newborn Infants with Cleft Lip and Palate: Diagnosis, Frequency, and Significance

Cited by 7 publications

References 8 publications

Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate

Prevalence of Egfr, Ki-67, Nf-Κb, Ma-1 marker in cleft affected tissue of soft palate

Profiling and Characterization of Localized Cytokine Response in Congenital Cleft Affected Lip Tissue

Introduction to clinical provision of nasoalveolar molding

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