Congenital papular xanthoma

Papular xanthoma: a clinicopathological study of 10 cases

“…Electron microscopy of several studies 2,17, 22–24, 26,28,31 showed within the foamy macrophages intracytoplasmatic fatty droplets which were not limited by a membrane. The lipid droplets were markedly electron dense, indicating a high content of unsaturated fatty acids 24 .…”

“…Papular xanthoma (PX) was first described in 1980 as a distinct xanthomatous lesion, usually without an underlying metabolic disorder 12 . Until now, 43 cases of cutaneous PX have been described (Table 2) in a solitary or disseminated distribution 13,22–31 . Recently, PX has also been described in the larynx 29 and as a congenital disorder 31 …”

Case Report-Papular Xanthoma in a 10-Year-Old Female with Abnormal Lipid Profile

“…While the histological features of PX have been validated by repeat evaluation (3,5–7), the presentation of our patient and that reported by Thomas should prompt re‐examination of the clinical profile. A congenital case of PX was reported in 2000 by Kim et al (8). While the infant had a normal lipid profile for age, there was no evaluation of the mother, leading us to assume that the PX developed in an arena of normal lipid values.…”

Multiple papular xanthomas mimicking juvenile xanthogranulomas in an infant: A case report and review of the literature

“…In general, lesions presenting in childhood tended to be self-limited, some healing with anetodermalike scars, while adult-onset papular xanthoma more commonly persisted. Of the 53 patients reported with papular xanthoma, 1,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] 35 were part of four comprehensive cases series. 6,7,9,13 Of the three series reporting follow-up, 6,13 18 patients were tracked with a median follow-up of 28 months (mean 41.3 months), of which two patients experienced recurrent or persistent lesions.…”