Congenital toxoplasmosis in humans: an update of worldwide rate of congenital infections

Dubey, J. P.; Murata, Fernando Henrique Antunes; Cerqueira‐Cézar, Camila K.; Kwok, O. C. H.; Villena, Isabelle

doi:10.1017/s0031182021001013

Cited by 84 publications

(79 citation statements)

References 86 publications

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“…In the USA and UK, approximately 16%-40% of the population is infected, and this rate increases further in Central America and Continental Europe where infection rates reach 50%-80% [8]. In addition, T. gondii can be vertically transmitted during pregnancy from an immunologically naive mother to her fetus, with the prevalence of congenital toxoplasmosis reaching up to 10 per 10,000 live births in some countries/settings [9]. Epidemiological surveys carried out among pregnant women and women of childbearing age have repeatedly shown a considerable variation in the seroprevalence of Toxoplasma infection ranging from 7.5% to 92.5 % in different parts of the world; 9%-11% in the USA, and 72% in Brazil [10].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Iqbal¹,

Khadadah²,

Mohammed³

2021

Preprint

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Background: Toxoplasmosis is caused by an obligate intracellular opportunistic protozoan parasite, Toxoplasma gondii, with a worldwide distribution. T. gondii infection among pregnant women during the first trimester may transmit infection to the fetus with serious congenital consequences. No data is available on knowledge, attitude and preventive behavior towards toxoplasmosis among pregnant women in Kuwait. This cross-sectional study evaluated knowledge, attitude, and preventive behavior towards toxoplasmosis among women in Kuwait, and reviewed the situation in the Middle east.Methods: Data related to socioeconomic status, knowledge and attitude towards toxoplasmosis were collected from 326 adult female school/university students, and 86 pregnant women through a self-administered online questionnaire during 2019-2021. Participants were divided into two main groups: women with pregnancy experience (PEG) and never-pregnant group (NPG).Results: PEG (n=212) included 114 currently pregnant and 98 women with history of an earlier pregnancy. NPG included 200 subjects. All participants belonged to a medium-to-high social status and minimum high school education. Nearly 50% of PEG women had inadequate knowledge towards toxoplasma infection, and only 33 (15.6%) knew its mode of transmission compared to 35 (17.5%) in the NPG (P=0.597). A significantly higher number of women in PEG (97 of 212, 45.8%) knew it can be prevented compared to 66 of 200 (33%) in NPG (P= 0.008). Only 35 (16.5%) of PEG women knew about screening tests for toxoplasma infection, and their main source of information on toxoplasmosis was healthcare professionals and family/friends compared with NPG women who got information through newspapers/books. PEG Women exhibited enhanced preventive behavior towards toxoplasmosis. Nearly 50% of all PEG participants lacked basic knowledge towards toxoplasmosis but >90% of them avoided most high-risk activities during their pregnancy. In addition, this is the first study in the Middle east conducted through an online survey to collect relevant information related to toxoplasmosis from pregnant women. Conclusions: This study highlights inadequate knowledge and preventive behavior towards toxoplasmosis among Kuwaiti women. Thus, health education on toxoplasmosis should be offered to all adult/pregnant women to reduce congenital toxoplasmosis.

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Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Iqbal¹,

Khadadah²,

Mohammed³

2021

Preprint

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“…It has been estimated that congenital toxoplasmosis infections occur in approximately 1 in 10,000 births in the United States, or approximately 3800 per year. Studies from France and Brazil that have provided a longer follow-up of possible cases have reported congenital infection rates up to ten times higher than the US study [22][23][24].…”

Section: What Is Known Regarding Human Infections?mentioning

confidence: 76%

The Case for Toxoplasma gondii in Psychosis and Other Human Diseases

Torrey

2021

Parasites, Pussycats and Psychosis

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“…These are reviewed and summarized in order to emphasize the importance of, and steps to build, programs to address the clinical and public health challenges of preventing congenital toxoplasmosis. This analysis and discussion places work in the United States [ 1 ••, 2 , 3 ••, 4 ••, 5 ••, 6 ••, 7 ••, 8 ••, 9 ••, 10 ••, 11 ••, 12 , 13 , 14 ••, 15 ••, 16 ••, 17 ••, 18 •, 19 •, 20 •, 21 •, 22 •, 23 , 24 ••, 25 , 26 , 27 •, 28 •, 29 – 30 , 31 •, 32 •, 33 ••, 34 •, 35 •, 36 , 37 •, 38 •, 39 ••, 40 •, 41 •, 42 ••, 43 ••, 44 ••, 45 , 46 •, 47 ••, 48 ••, 49 , 50 , 52 , 55 ••, 56 ••], Panama [ 59 •] and Colombia [ 63 , 65 , 97 ], in the context of progress in other countries [ 51 •, 52 , 53 ••, 54 , 55 ••, 56 ••, 57 •, 58 ••, 59 •, 60 ••, 61 , …”

Section: Introductionmentioning

confidence: 99%

Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”

Felín¹,

Wang

Moreira

et al. 2022

Curr Pediatr Rep

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Purpose of Review Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings Multiple countries’ efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes.

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Congenital toxoplasmosis in humans: an update of worldwide rate of congenital infections

Abstract: Abstract

Cited by 84 publications

References 86 publications

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

Knowledge, Attitude And Preventive Behavior Towards Toxoplasmosis Among Kuwaiti Women With/Without Pregnancy Experience: A Cross Sectional Study

The Case for Toxoplasma gondii in Psychosis and Other Human Diseases

Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”

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