Congenital Tuberculosis: A Missed Opportunity

Mony, Vidya; Polin, Jennifer; Adler, Esther; Munjal, Iona; LaTuga, M. Susan; Kojaoghlanian, Tsoline

doi:10.1093/jpids/piu029

Cited by 14 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, TB tests before IVF are not routine. 5,6,10,13–22 Infertility caused by genital TB is common in countries with a high TB burden, and IVF is considered to be an effective treatment to improve fertility. Therefore, this may lead to more CTB cases without thorough TB tests before IVF.…”

Section: Discussionmentioning

confidence: 99%

Congenital tuberculosis after in vitro fertilization: suggestion for tuberculosis tests in infertile women in developing countries

Xiao-ling

Ren

et al. 2018

J Int Med Res

View full text Add to dashboard Cite

Congenital tuberculosis (CTB) after in vitro fertilization (IVF) is a major new problem in developing countries. Only 16 cases of CTB after IVF have been reported, and no tuberculosis (TB) tests were performed before IVF in these cases. However, on the basis of data in the literature and from the World Health Organization, the incidence of CTB has been substantially underestimated. We describe two cases of CTB after IVF in detail in our center and provide new insight into the important issue of controlling TB vertical transmission in developing countries. Performing an early diagnosis of CTB, mostly based on evidence of maternal infection and a high index of clinical suspicion, is a challenge. However, most mothers have no symptoms of TB infection during prepartum, and infertility may be the only symptom. Infertility caused by genital TB is common in countries with a high TB burden, and IVF is considered to be an effective treatment to improve their fertility. Therefore, this may lead to more CTB cases without thorough TB tests before IVF. We suggest that thorough TB tests should be conducted in infertile women before IVF to prevent CTB.

show abstract

Section: Discussionmentioning

confidence: 99%

Congenital tuberculosis after in vitro fertilization: suggestion for tuberculosis tests in infertile women in developing countries

Xiao-ling

Ren

et al. 2018

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…Most women became symptomatic postnatally with active pulmonary disease, prompting newborn evaluation. Few reports had postnatally asymptomatic mothers while infants had active disease [23].…”

Section: Discussionmentioning

confidence: 99%

A Review on Placental Tuberculosis

Trivedi¹,

Gupta²,

Sood³

et al. 2020

JAMMR

View full text Add to dashboard Cite

Tuberculosis has re-emerged as a serious health concern as a result of AIDS epidemic, immigration from areas where the disease is endemic and multi drug resistance, with 8.8 million patients affected worldwide in 2010. Infections with mycobacterium tuberculosis (MTb) are globally prevalent in many countries, yet descriptions of placental pathology in tuberculous patients are few. Moreover, the diagnosis of tuberculosis in pregnant patients can be missed or delayed owing to the insidious onset and variability of clinical presentation, often overlapping with non-specific symptoms common in pregnancy such as loss of appetite, malaise and lethargy. The exact incidence of tuberculosis in pregnancy is not readily available in many countries due to confounding factors. However, it is expected that the incidence of tuberculosis in pregnant women is high as in general population, with higher incidence in developing countries. Placental tuberculosis shows predominantly neutrophilic and histiocytic response in the form of villitis and intervillitis which is due to the innate immune response. This innate response contributes more to tissue injury than protection as proved in our case, where it led to intrauterine death of the fetus. We, hereby report a case of placental tuberculosis, diagnosed on histopathological examination of placenta showing caseating epithelioid cell granulomas with langhan’s giant cells and Acid Fast Bacilli on Zeihl Neilson stain.

show abstract

“…Congenital tuberculosis is a rare entity [23][24][25][26][27][28][29] but it should be discarded in infected neonates or infants. The diagnosis is based on Cantwell criteria, but our patient did not fulfill the criteria.…”

Section: Discussionmentioning

confidence: 99%