Congenital ulcerated nodule: self-healing Langerhans cell histiocytosis

Gomes, Tiago Fernandes; Cardoso, José Carlos; Guiote, Victoria; Santiago, Felicidade

doi:10.1016/j.abd.2021.12.012

Anais Brasileiros de Dermatologia

2023

DOI: 10.1016/j.abd.2021.12.012

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Congenital ulcerated nodule: self-healing Langerhans cell histiocytosis

Tiago Fernandes Gomes¹,

José Carlos Cardoso²,

Victoria Guiote³

et al.

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2023

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Hypopigmented white patches in a newborn

Palmeiro,

Pimentel,

Castro

et al. 2023

Clinical and Experimental Dermatology

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A newborn developed multiple hyperkeratotic erythematous papules, some with central erosions, mainly located on her scalp and trunk. Histopathology revealed a dense infiltrate of monotonous mononuclearcells with pale pink cytoplasm and reniform nuclei, positive for CD1a, S100 protein, and langerin. A diagnosis of congenital self-healing Langerhans cell histiocytosis was made. Extracutaneous involvement was excluded and the patient is stable at 3 months follow-up. Congenital Self-Healing Langerhans cell histiocytosis (CSHLCH) is a rare variant of LCH. Long term follow up is recommended, as relapse of cutaneous manifestations or subsequent visceral involvement have been described, especially in the first year of life.

show abstract

Hypopigmented white patches in a newborn

Palmeiro,

Pimentel,

Castro

et al. 2023

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

show abstract

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Congenital ulcerated nodule: self-healing Langerhans cell histiocytosis

Cited by 1 publication

References 11 publications

Hypopigmented white patches in a newborn

Hypopigmented white patches in a newborn

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