2020
DOI: 10.1126/sciadv.aaw6284
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Congenital Zika syndrome is associated with maternal protein malnutrition

Abstract: Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine thi… Show more

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Cited by 63 publications
(54 citation statements)
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“…Still, in this context of environmental variables possibly involved with the teratogenic effects of ZIKV, the socioeconomic level has been discussed as a possible environmental factor associated with this asymmetric distribution of CZS in Brazil [ 22 ]. That discussion is important, since this variable was also associated with the availability and quality of mothers’ diets during pregnancy, a condition recently also associated with the development of CZS [ 23 ]. In the present sample, we observed that families of children with CZS had a lower socioeconomic level compared to families of children without CZS.…”
Section: Discussionmentioning
confidence: 99%
“…Still, in this context of environmental variables possibly involved with the teratogenic effects of ZIKV, the socioeconomic level has been discussed as a possible environmental factor associated with this asymmetric distribution of CZS in Brazil [ 22 ]. That discussion is important, since this variable was also associated with the availability and quality of mothers’ diets during pregnancy, a condition recently also associated with the development of CZS [ 23 ]. In the present sample, we observed that families of children with CZS had a lower socioeconomic level compared to families of children without CZS.…”
Section: Discussionmentioning
confidence: 99%
“…Overall, malnutrition can compromise the immune response [ 70 ], altering cell regeneration and function and making individuals more prone to infection [ 71 ]. For example, it is well known that in economically poor areas with protein-malnutrition [ 72 ], the risk of infection is elevated, though additional factors such as tropical diseases may also be a factor [ 73 , 74 ]. In addition, inflammation related to poor dietary habits has reached alarming proportions [ 75 ], especially with regard to numerous cardio-metabolic diseases related to low-grade chronic inflammation such as overweight/obesity, T2D, metabolic syndrome, and auto-immune and cardiovascular diseases.…”
Section: The Immune System Covid-19 Inflammation and Oxidativementioning
confidence: 99%
“…Recently, maternal protein deficiency was associated with increased susceptibility to congenital Zika syndrome, a condition characterized by developmental impairment in the fetus and caused by maternal Zika virus infection ( Barbeito-Andrés et al , 2020 ). This finding exemplifies how nutritional status can act as an important cofactor in the outcome of viral infections.…”
Section: Actions For Control and Prevention Of Infectious Diseases: Amentioning
confidence: 99%