Conifer Green Needle Complex in Patients with Precancerous Gastric Lesions: An Observational Pilot Study

Беспалов, В. Г.; Sherbakov, Alexander; Novik, V I; Kalinovsky, V. P.; Shamsi, Kamran; Soultanov, Vagif

doi:10.1155/2016/3848409

Cited by 6 publications

(9 citation statements)

References 41 publications

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“…Polyprenols have been arousing interest already since the 1960s [27]. Nowadays, we have much more information not only on the synthetic pathways of polyprenol and dolichol (α-saturated isoprenoids) formation [28] but also further scientific questions are being asked, whether polyprenols and dolichols are super-lipids [29] and to what degree they can be applied in prophylaxis and treatment of different diseases [30]. So far, polyprenols have been extracted from a plethora of various plants [7,31,32], but many novel synthesized derivatives have been described as well [33].…”

Section: Discussionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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The needles of conifer trees are one of the richest sources of natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) were observed in the ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram of Siberian fir with the most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% of the total polyprenol yield). Abies sibirica L. polyprenol solubility and incorporation efficiency into liposomes were studied in various commercially available lecithin mixtures (Phosal IP40, Phosal 75SA, and Lipoid P45). The resulting multilamellar polyprenol liposomes were morphologically characterized by Light and Transmission Electron Microscopy, and the liposome size was discovered to be polymodal with the main peak at 1360 nm (90% of the volume). As polyprenols are fully soluble only in lipids, a liposomal formulation based upon co-solubilization and a modified ethanol injection method of polyprenols into the ethanol-phospholipid system was developed for the entrapment and delivery of polyprenols for potential commercial applications in food supplement and cosmetic industries.

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Section: Discussionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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“…In an observational pilot study conducted in Russia, a tablet form of Conifer Green Needle Complex (CGNC) extracted from Pinus sylvestris and Picea abies (L) Karst was prescribed to 26 patients with precancerous gastric lesions for 6 months [24]. Another 24 patients received no treatment (control/no placebo).…”

Section: Conifer Green Needle Complexmentioning

confidence: 99%

Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?

Wang

Echeveste

et al. 2020

eFood

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More than 50% of the world's population is infected with Helicobacter pylori. H. pylori is the major causative agent of gastric ulcers and gastric cancer. H. pylori eradication using antibiotics either alone or together with a proton pump inhibitor is the primary strategy to decrease the incidence of gastric cancer. Although eradication therapy is effective, there are significant adverse effects and more importantly, resistance to antibiotics occurs, which represents a major therapeutic challenge. Multiple natural products have been shown to suppress H. pylori both in vitro and in animal model systems. However, only a handful of natural products have been evaluated in human clinical trials. The focus of this review is to summarize the results of published human clinical trials to assess the ability of natural products to reduce or eliminate H. pylori infections. Current evidence suggests that these products appear to have great potential to be developed as pharmaceutical candidates for eradication of H. pylori, hopefully both antibiotic-sensitive and antibiotic-resistant strains. Frequent consumption of locally produced foodstuff for controlling H. pylori infection in different countries around the world may well be a feasible long-term solution to fight against this worldwide prevalent pathogen.

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“…Several group of phytochemicals such as terpenes, β-glycosides, saponins, essential oils and alkaloids inhibit T. vaginalis [23,24]. CGNC has antioxidant properties [25] and antimicrobial activities [19,20] and has been shown to suppress Helicobacter pylori in vitro and in vivo [26][27][28][29].…”

mentioning

confidence: 99%

Anti-protozoal Activity of Conifer Green Needle Complex against Trichomonas vaginalis

Kulyashova

Roschina

Nikitina

et al. 2019

Natural Product Communications

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Treatment of Trichomonas vaginalis typically involves using nitroimidazoles (such as metronidazole and tinidazole). Some T. vaginalis strains have become resistant to these drugs, so the development of new drugs is necessary. Clinical samples were taken from 80 males and 70 females (aged 17-45). The sensitivity of T. vaginalis in these samples to CGNC (100, 200, 300 and 500 mg/mL) and metronidazole (10, 15, 25 and 50 µg/mL) was evaluated. All 10 isolates were sensitive to at least one concentration of CGNC. Three strains were sensitive (all cells were killed) to 100 mg/mL CGNC, while there was a decrease in the number of Trichomonas present in the other samples when compared with the control. Six strains were sensitive to 200 mg/mL CGNC, while those strains that grew in the presence of CGNC showed a reduction in numbers when compared with the control. Nine strains were sensitive to 300 mg/mL CGNC. The strain not sensitive to 300 mg/mL CGNC showed a decrease in the number of Trichomonas present (<10 2 cells/mL) when compared to the control (10 4 cells/mL). All strains were sensitive to 500 mg/mL CGNC. Three strains (one motile and two non-motile) were sensitive to all concentrations of CGNC and one of the non-motile strains was resistant (MIC 50 µg/mL) to metronidazole. The other two strains were moderately resistant (MIC 15 and 25 µg/mL) to metronidazole. Of the 10 Trichomonas strains, four were resistant to metronidazole (MIC 50 µg/mL) and sensitive to at least one concentration of CGNC. CGNC may be used as a treatment for T. vaginalis infections and should be considered for clinical strains resistant to metronidazole.

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Conifer Green Needle Complex in Patients with Precancerous Gastric Lesions: An Observational Pilot Study

Cited by 6 publications

References 41 publications

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Can Natural Products Suppress Resistant Helicobacter pylori to Fight Against Gastric Diseases in Humans?

Anti-protozoal Activity of Conifer Green Needle Complex against Trichomonas vaginalis

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