Conjugate Electrospun 3D Gelatin Nanofiber Sponge for Rapid Hemostasis (Adv. Healthcare Mater. 20/2021)

Xie, Xianrui; Li, Dan; Chen, Yujie; Shen, Yulong; Yang, Fan; Wang, Wei; Yuan, Zhengchao; Morsi, Yosry; Wu, Jian; Mo, Xiumei

doi:10.1002/adhm.202170095

Cited by 18 publications

(22 citation statements)

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“…Fibers are one of the most frequently used hemostatic carriers. [ 10,29–31 ] Thus, we fabricated polycaprolactone (PCL) nanofibers to support keratin films and evaluated their hemostatic activities ( Figure A). Figure 2B shows the morphology of as‐prepared thin films under scanning electron microscopy (SEM).…”

Section: Resultsmentioning

confidence: 99%

Rational Design of High‐Performance Keratin‐Based Hemostatic Agents

Wang

Zhang

et al. 2022

Adv Healthcare Materials

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Keratins are considered ideal candidates as hemostatic agents, but the development lags far behind their potentials due to the poorly understood hemostatic mechanism and structure-function relations, owing to the composition complexity in protein extracts. Here, it is shown that by using a recombinant synthesis approach, individual types of keratins can be expressed and used for mechanism investigation and further high-performance keratin hemostatic agent design. In the comparative evaluation of full-length, rod-domain, and helical segment keratins, the 𝜶-helical contents in the sequences are identified to be directly proportional to keratins' hemostatic activities, and Tyr, Phe, and Gln residues at the N-termini of 𝜶-helices in keratins are crucial in fibrinopeptide release and fibrin polymerization. A feasible route to significantly enhance the hemostatic efficiency of helical keratins by mutating Cys to Ser in the sequences for enhanced water wettability through soluble expression is then further presented. These results provide a rational strategy to design high-efficiency keratin hemostatic agents with superior performance over clinically used gelatin sponge in multiple animal models.

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Section: Resultsmentioning

confidence: 99%

Rational Design of High‐Performance Keratin‐Based Hemostatic Agents

Wang

Zhang

et al. 2022

Adv Healthcare Materials

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“…The gelatin nanofiber sponge activates platelets in large quantities to promote the formation of the platelet embolism and simultaneously escalated the extrinsic and intrinsic coagulation pathways. In vivo studies using a rabbit ear artery injury model and a rabbit liver demonstrated the superior capability of the gelatin nanofiber sponge in forming stable blood clots in the shortest time with the least blood loss [39] . Overall, the amphiphilicity of the nanofiber dressings and the incorporated clotting factors play significant roles in hemorrhage control.…”

Section: Control Hemorrhagementioning

confidence: 98%

“…Similarly, Mo et al . reported ultralight gelatin nanofiber sponges for hemostasis [39] . The gelatin nanofiber sponge activates platelets in large quantities to promote the formation of the platelet embolism and simultaneously escalated the extrinsic and intrinsic coagulation pathways.…”

Section: Control Hemorrhagementioning

confidence: 99%

Electrospun Nanofibers for Wound Management

et al. 2021

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Electrospun nanofibers show great potential in biomedical applications. This minireview traces the recent advances in electrospun nanofibers for wound management via various approaches. Initially, we provide a short note on the four phases of wound healing, including hemostasis, inflammation, proliferation, and remodeling. Then, we state how the nanofiber dressings can stop bleeding and reduce the pain. Following that, we discuss the delivery of therapeutics and cells using different types of nanofibers for enhancing cell migration, angiogenesis, and re-epithelialization, resulting in the promotion of wound healing. Finally, we present the conclusions and future perspectives regarding the use of electrospun nanofibers for wound management.

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“…[ 17,38,39 ] However, MN patches have not been applied to wounds, where underlying blood capillaries are damaged and exposed. Although recent reports have successfully demonstrated wound closure as a regenerative dressing material, [ 40–43 ] previous studies focused on incision wounds, which are less frequently caused by accidents. [ 40,44–47 ]…”

Section: Introductionmentioning

confidence: 99%

Peripheral Microneedle Patch for First‐Aid Hemostasis

Lee

Park

et al. 2023

Adv Healthcare Materials

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Despite the minimized puncture sizes and high efficiency, microneedle (MN) patches have not been used to inject hemostatic drugs into bleeding wounds because they easily destroy capillaries when a tissue is pierced. In this study, a shelf-stable dissolving MN patch is developed to prevent rebleeding during an emergency treatment. A minimally and site-selectively invasive hemostatic drug delivery system is established by using a peripheral MN (p-MN) patch that does not directly intrude the wound site but enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is histologically examined by using a bleeding liver of a Sprague-Dawley (SD) rat as an extreme wound model in vivo. The skin penetration force is quantified to demonstrate that the administration of the p-MN patch is milder than that of the conventional MN patch. Hemostatic performance is systematically studied by analyzing bleeding weight and time and comparing them with that of conventional hemostasis methods. The superior performance of a p-MN for the heparin-pretreated SD rat model is demonstrated by intravenous injection in vivo.

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Conjugate Electrospun 3D Gelatin Nanofiber Sponge for Rapid Hemostasis (Adv. Healthcare Mater. 20/2021)

Cited by 18 publications

References 0 publications

Rational Design of High‐Performance Keratin‐Based Hemostatic Agents

Rational Design of High‐Performance Keratin‐Based Hemostatic Agents

Electrospun Nanofibers for Wound Management

Peripheral Microneedle Patch for First‐Aid Hemostasis

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