Conjugate vaccines for preventing meningococcal C meningitis and septicaemia

Bramley, J. C.; Begg, NT; Booy, Robert; Buttery, Jim; Finn, Adam; Heath, PT; Jones, I. G.; Richmond, PC; Rosenstein, NE

doi:10.1002/14651858.cd001834

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Antibiotics for preventing meningococcal infections

Fraser¹,

Gafter‐Gvili²,

Leibovici³

2005

Cochrane Database of Systematic Reviews

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Given the fact that the use of rifampin in an outbreak setting might lead to the circulation of isolates resistant to rifampin, use of ciprofloxacin or ceftriaxone should be considered.Placebo-controlled trials do not seem ethical as prophylactic treatment has been proven to reduce the risk of disease among household contacts. More trials comparing the effectiveness of ceftriaxone, ciprofloxacin and rifampin for eradicating N. meningitidis could provide important insights.

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Antibiotics for preventing meningococcal infections

Fraser¹,

Gafter‐Gvili²,

Leibovici³

2005

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

Antibiotics for preventing meningococcal infections

Fraser

Gafter‐Gvili

Leibovici

2006

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Given the fact that the use of rifampin in an outbreak setting might lead to the circulation of isolates resistant to rifampin, use of ciprofloxacin or ceftriaxone should be considered. Evidence suggests that all three agents are effective with up to two weeks follow up. Placebo-controlled trials do not seem ethical as prophylactic treatment has been proven to reduce the risk of disease among household contacts. More trials comparing the effectiveness of ceftriaxone, ciprofloxacin and rifampin for eradicating N. meningitidis would provide important insights.

show abstract