Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia

Hoose, Patrick M Van; Kelm, Natia Qipshidze; Piell, Kellianne M.; Cole, Marsha P.

doi:10.1016/j.jnutbio.2016.04.001

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…They were assigned as biologically relevant and putative signaling molecules in cardiovascular disease [28], [33], myocardial ischemia/reperfusion and ischemia preconditioning [1], [2], [24], nephropathy [24], renal ischemia/reperfusion [24], diabetes and metabolic syndrome [14], pulmonary inflammation [15], [67] and chronic inflammatory disease [65]. NO 2 -FA reach endogenous levels that allow them to mediate pivotal signaling actions as cytoprotective and pro-survival players [2], [34], [35], [36], [37], and based on their pleiotropic actions, NO 2 -FA has emerged as potential therapeutic agents with high potential for therapeutic use (Table 2). In fact, NO 2 -FA already undergo clinical trials [68].…”

Section: Endogenous Nitro-fatty Acidsmentioning

confidence: 99%

“…This modification of functionally-relevant proteins can modulate the patterns of gene expression programs, transcription factors function, enzyme function and activity, metabolic and inflammatory responses, and cell signaling networks [50], [59], [73], [84]. This lead to a series of downstream signaling events that are intrinsically related to the biological signaling roles of NO 2 -FA [2], [6], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [61], [74], [75], [86], [87], [88], [89], [90] (Table 2). The activation of several of these pathways are considered essential for restoring the homeostasis and the redox balance and makes NO 2 -FA promising pharmacological compounds [91].…”

Section: Nitro-fatty Acids and Protein Lipoxidation Adductsmentioning

confidence: 99%

“…These products have been widely detected in several tissues [1], [2], [3], [4], [5] and biofluids [6], [7], [8], [9], [10], [11], [12], and are nowadays a hot topic in nitro lipidomics. NO 2 -FA are considered important bioactive molecules and have been associated with anti-inflammatory [6], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], anti-hypertensive [25], [26], [27], [28], [29], [30], [31], [32], and anti-thrombotic properties [31], [33] and cytoprotective effects [2], [34], [35], [36], [37]. More recently, other nitrated and nitroxidized lipids [1], [6], [7], [8], [13], [38] and also nitro derivatives of phospholipids (PL) [39], [40] and triglycerides (TAG) [41] have been detected in biological samples and were associated with protective and beneficial effects, but they are scarcely studied.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches

et al. 2019

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Nitro-fatty acids (NO2-FA) undergo reversible Michael adduction reactions with cysteine and histidine residues leading to the post-translational modification (PTM) of proteins. This electrophilic character of NO2-FA is strictly related to their biological roles. The NO2-FA-induced PTM of signaling proteins can lead to modifications in protein structure, function, and subcellular localization. The nitro lipid-protein adducts trigger a series of downstream signaling events that culminates with anti-inflammatory, anti-hypertensive, and cytoprotective effects mediated by NO2-FA. These lipoxidation adducts have been detected and characterized both in model systems and in biological samples by using mass spectrometry (MS)-based approaches. These MS approaches allow to unequivocally identify the adduct together with the targeted residue of modification. The identification of the modified proteins allows inferring on the possible impact of the NO2-FA-induced modification. This review will focus on MS-based approaches as valuable tools to identify NO2-FA-protein adducts and to unveil the biological effect of this lipoxidation adducts.

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Section: Endogenous Nitro-fatty Acidsmentioning

confidence: 99%

Section: Nitro-fatty Acids and Protein Lipoxidation Adductsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches

et al. 2019

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“…The combined administration of linoleic acid and nitrite can play a cardioprotective effect in the event of MI. It can reduce the level of hydrogen peroxide and significantly change the activity of myocardial mitochondrial respiration and electron transport chain 36 . It was found that the 1-Monolinolein may be the key compound for the hemostatic effect of Cortex Moutan.…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking

Huo

Liu³

2021

Sci Rep

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Yixinyin, the traditional Chinese medicine, has the effects of replenishing righteous qi, and promoting blood circulation to eliminate blood stagnation. It is often used to treat patients with acute myocardial infarction (MI). The purpose of our study is to explore the key components and targets of Yixinyin in the treatment of MI. In this study, we analyzed gene expression data and clinical information from 248 samples of MI patients with the GSE34198, GSE29111 and GSE66360 data sets. By constructing a weighted gene co-expression network, gene modules related to myocardial infarction are obtained. These modules can be mapped in Yixinyin PPI network. By integrating differential genes of healthy/MI and unstable angina/MI, key targets of Yixinyin for the treatment of myocardial infarction were screened. We validated the key objectives with external data sets. GSEA analysis is used to identify the biological processes involved in key targets. Through molecular docking screening, active components that can combine with key targets in Yixinyin were obtained. In the treatment of myocardial infarction, we have obtained key targets of Yixinyin, which are ALDH2, C5AR1, FOS, IL1B, TLR2, TXNRD1. External data sets prove that they behave differently in the healthy and MI (P < 0.05). GSEA enrichment analysis revealed that they are mainly involved in pathways associated with myocardial infarction, such as viral myocarditis, VEGF signaling pathway and type I diabetes mellitus. The docking results showed that the components that can be combined with key targets in YixinYin are Supraene, Prostaglandin B1, isomucronulatol-7,2′-di-O-glucosiole, angusifolin B, Linolenic acid ethyl ester, and Mandenol. For that matter, they may be active ingredients of Yixinyin in treating MI. These findings provide a basis for the preliminary research of myocardial infarction therapy in traditional Chinese medicine and provide ideas for the design of related drugs.

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“…Regarding the first one, circulating levels of magnesium have been indirectly associated with cardiovascular events and with the prevalence of diabetes mellitus and hypertension [30]. Indeed, magnesium is the second most abundant intracellular electrolyte after potassium and has important functions as a cofactor of enzymatic reactions involved in carbohydrate metabolism but also in vascular tone and endothelial function [31]. Concerning CCS, preclinical evidence has shown that magnesium supplementation leads to a reduction of myocardial infarct size in animals [32].…”

Section: Magnesiummentioning

confidence: 99%

Nutraceuticals in Chronic Coronary Syndromes: Preclinical Data and Translational Experiences

Tognola

Maloberti

Milani

et al. 2020

High Blood Press Cardiovasc Prev

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Non-pharmacological treatments have always been considered important in the management of Chronic Coronary Syndromes. Nutraceuticals ("Nutrition" + "Pharmaceutical") could fall both under the definition of non-pharmacological treatment and pharmacological one or, probably more correctly, in the middle of these two kinds of therapies. However, the word "nutraceuticals" never appears in the latest guidelines on this issue. This is probably determined by the fact that evidences on this topic are scarce and most of the published articles are based on preclinical data while translational experiences are available only for some molecules. In this review we will focus on nutraceutical strategies that act on the ischemic myocardium itself and not only on the cardiovascular risk factors. As demonstrated by the important number of papers published in recent years, this is an evolving topic and evaluated substances principally act on two mechanisms (cardiac energetics and ischemia-reperfusion damage) that will be also reviewed.

show abstract

Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia

Cited by 7 publications

References 31 publications

Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches

Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches

Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking

Nutraceuticals in Chronic Coronary Syndromes: Preclinical Data and Translational Experiences

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