Conjugated Linoleic Acid Is a Growth Factor for Rats as Shown by Enhanced Weight Gain and Improved Feed Efficiency ,

Chin, Sou F.; Storkson, Jayne M.; Albright, Karen; Cook, Mark E.; Pariza, Michael W.

doi:10.1093/jn/124.12.2344

Cited by 235 publications

(181 citation statements)

References 16 publications

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“…The failure to observe consistent changes in tissue CLA content of pigs sampled at birth leads one to question whether there is placental transfer. Heart, kidney, and adipose tissues did show changes in fatty acids but these patterns were not similar to those previously described in other animal models [7]. CLA accretion was observed in the kidneys and hearts of newborn pigs from CLA fed sow's indicating CLA did transfer across the placenta to fetal tissues.…”

Section: Resultscontrasting

confidence: 62%

Conjugated linoleic acid (CLA) during gestation and lactation does not alter sow performance or body weight gain and adiposity in progeny

2004

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-The objective of this study was to determine the long-term effects of conjugated linoleic acid (CLA) in pigs exposed to CLA during fetal and neonatal growth. Sows were fed a diet with 0.83% soy oil or 0.83% CLA-60 containing 60% active CLA isomers from either d 40 (group 1; CON n = 8, CLA n = 6) or d 75 (group 2; CON n = 8, CLA n = 8) of gestation through weaning on d 28. Within group 1, one male and one female piglet per litter (CON n = 6, CLA n = 5) were sacrificed within 24 hours of birth (d 0) and body weights recorded. Semitendinosus muscle, subcutaneous adipose tissue and organs, including heart, liver, lung, kidney, brain were weighed and tissue samples were frozen. Two average weight barrows and two gilts per litter were weaned and fed standard diets without added CLA until market weight. CLA did not alter sow's feed intake during gestation or lactation, body weight or backfat thickness, and litter size and weight at birth (P > 0.05). CLA decreased newborn pig heart, but not backfat or semitendinosus muscle weights relative to their body weights (d 0). CLA decreased pre-weaning weight in selected piglets but this was not maintained post-weaning. CLA decreased total milk fat by 17% (P < 0.01) and resulted in an increase in the relative amount of saturated fatty acids and a decrease in the relative amount of unsaturated fatty acids in milk on d 21 of lactation (P < 0.05). Decreases in growth rates until d 14 may be due to decreased fat in sow's milk since growth rate and body weight of selected progeny did not differ post-weaning. Serum from newborn CLA pigs suppressed relative preadipocyte number and did not change lipid filling in stromal-vascular cell cultures. The response to this serum was greater in females than in males (P Diet = 0.04; P Diet × Gender = 0.04). Thus, there do not seem to be any long-term effects on growth and body composition of market weight pigs given 0.5% CLA through weaning that would be beneficial in a production scheme. Résumé -La distribution d'acide linoléique conjugué (CLA) pendant la gestation et la lactation n'affecte ni les performances des truies ni le gain de poids corporel et l'adiposité de leurs porcelets. L'objectif de cette étude était de déterminer les effets à long terme de l'acide linoléique conjugué (CLA) chez les porcs recevant du CLA pendant leur croissance foetale et néonatale. Des truies ont été alimentées avec un régime à base d'huile de soja (0,83 %, CON) ou de CLA-60 (0,83 %, CLA) contenant 60 % des isomères actifs de CLA, soit à partir du 40 e jour de gestation (groupe 1 ; CON n = 8, CLA n = 6) soit au 75 e jour de gestation (groupe 2 ; CON n = 8, CLA n = 8) jusqu'au sevrage (28 jours après la naissance). Dans le groupe 1, un porcelet mâle et un porcelet femelle par portée (CON n = 6, CLA n = 5) ont été sacrifiés à moins de 24 heures de la naissance (d 0) et le poids corporel des animaux enregistré. Le muscle semitendinosus, le tissu adipeux sous-cutané et les organes, comprenant le coeur, le foie, le poumon, les reins ainsi que le cerveau ont ...

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Section: Resultscontrasting

confidence: 62%

Conjugated linoleic acid (CLA) during gestation and lactation does not alter sow performance or body weight gain and adiposity in progeny

2004

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“…Yuan et al (2009b) showed that diet supplemented with 1.0% conjugated linolenic acid (CLnA) isomers (α-eleostearic and/or punicic acid) fed for 6 weeks did not significantly affect the body mass of mice. In contrast, Chin et al (1994) reported that conjugated linoleic acid (CLA) is a dietary factor enhancing rats growth. In the study of Arao et al (2004) with obese, hyperlipidaemic Otsuka LongEvans Tokushima Fatty (OLETF) rats, dietary PSO reduced weight of omental white adipose tissues, but not that of abdominal white adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary pomegranate seed oil and linseed oil on broiler chickens performance and meat fatty acid profile

Szymczyk¹,

Szczurek²

2016

J. Anim. Feed Sci.

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“…CLA supplementation during gestation and lactation elicits greater body weight and feed efficiency in weanling mice relative to control animals 22 . This effect on feed efficiency and growth seems to be exerted by the cis-9,trans-11 isomer 4 .…”

Section: Evidence Of Conjugated Linoleic Acid Effects On Body Weight mentioning

confidence: 93%

Conjugated linoleic acid (CLA) and obesity

Silveira

Carraro

Monereo

et al. 2007

Public Health Nutr.

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Background: The term conjugated linoleic acid (CLA) refers to several positional and geometric conjugated dienoic isomers of linoleic acid (LA), of which the trans-10,cis-12 isomer has been reported to reduce adiposity and increase lean mass in mice and other animals when included at #1% of the diet. However, most dietary CLA in humans is obtained from dairy products, accounting for the cis-9,trans-11 CLA isomer, also known as rumenic acid, for more than 90% of the total CLA intake. Commercial CLA preparations industrially produced, containing trans-10,cis-12 and cis-9,trans-11 CLA isomers in diverse proportions, are attracting consumers' interest because of the purported body fat-lowering effects of CLA, coupled to the perception of a 'natural' compound devoid of harmful effects. Nevertheless, despite numerous studies on CLA effects on body composition for nearly a decade, the mechanisms by which CLA isomers elicit their effects remain largely unknown. The purpose of this paper is to provide an updated review of the studies performed on animals and humans, as well as to describe the potential mechanisms involved in CLA effects on body weight and composition and metabolism. Method: Literature review. Results: Experiments in humans have not been able to show a significant effect on body weight, body composition or weight regain related to either of the CLA isomers. In fact, some studies suggest a tendency towards a decrease in body fat mass and an increase in body lean mass, while some others raise concern about the possibility of deleterious effects of trans-10,cis-12 CLA on lipid profile, glucose metabolism and insulin sensitivity. Conclusions: Evidence regarding effectiveness of CLA in humans is not concluding.

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Conjugated Linoleic Acid Is a Growth Factor for Rats as Shown by Enhanced Weight Gain and Improved Feed Efficiency ,

Cited by 235 publications

References 16 publications

Conjugated linoleic acid (CLA) during gestation and lactation does not alter sow performance or body weight gain and adiposity in progeny

Conjugated linoleic acid (CLA) during gestation and lactation does not alter sow performance or body weight gain and adiposity in progeny

Effect of dietary pomegranate seed oil and linseed oil on broiler chickens performance and meat fatty acid profile

Conjugated linoleic acid (CLA) and obesity

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