Conjugation of a photosensitizer to near infrared light renewable persistent luminescence nanoparticles for photodynamic therapy

Abdurahman, Renagul; Yang, Cheng‐Xiong; Yan, Xiu‐Ping

doi:10.1039/c6cc07616e

Cited by 82 publications

(58 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PLNPs with long-lasting NIR emission can serve as a persistent light source for PDT activation without any need for continuous photonic excitation [128][129][130]. This promising feature can minimize the deleterious side effects of PDT and provide convenient clinical cancer treatment without continuous external irradiation [131][132][133].…”

Section: Plnps-based Photodynamic Therapymentioning

confidence: 99%

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Ding

et al. 2020

Nano-Micro Lett.

140

View full text Add to dashboard Cite

Persistent luminescence phosphors are a novel group of promising luminescent materials with afterglow properties after the stoppage of excitation. In the past decade, persistent luminescence nanoparticles (PLNPs) with intriguing optical properties have attracted a wide range of attention in various areas. Especially in recent years, the development and applications in biomedical fields have been widely explored. Owing to the efficient elimination of the autofluorescence interferences from biotissues and the ultra-long near-infrared afterglow emission, many researches have focused on the manipulation of PLNPs in biosensing, cell tracking, bioimaging and cancer therapy. These achievements stimulated the growing interest in designing new types of PLNPs with desired superior characteristics and multiple functions. In this review, we summarize the works on synthesis methods, bioapplications, biomembrane modification and biosafety of PLNPs and highlight the recent advances in biosensing, imaging and imaging-guided therapy. We further discuss the new types of PLNPs as a newly emerged class of functional biomaterials for multiple applications. Finally, the remaining problems and challenges are discussed with suggestions and prospects for potential future directions in the biomedical applications.

show abstract

Section: Plnps-based Photodynamic Therapymentioning

confidence: 99%

Recent Advances of Persistent Luminescence Nanoparticles in Bioapplications

Ding

et al. 2020

Nano-Micro Lett.

140

View full text Add to dashboard Cite

show abstract

“…The characteristic afterglow emission of PeL-NPs can be used as an internal light source in PDT that would eliminate the need for continuous in situ illumination, avoiding skin and tissue damage, and allowing the use of PDT in deep tissues. Curiously, the use of PeL in PDT is recent, and the first examples were reported back in 2016 [ 275 , 276 ]. In those pioneer works, the proof-of-concept that PeL could potentially be used in PDT was reported using ZnGa 2 O 4 :1% Cr III , 2% Pr III as the PeL-NP, and the chemically bonded photosensitizer (PS) distyryl-BODIPY [ 275 ].…”

Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

“…As noted by Akkaya and co-workers, only a modest photocytotoxicity against HepG2 cells was observed due to the short PeL emission lifetime in biological media. Re-charging the PeL is a strategy to repopulate the excited states of the PeL-NP and restore the PeL [ 276 , 277 , 278 , 279 , 280 , 281 ]. Solubilizing in water and targeting the PeL-NPs into cancer cells adds another challenge for in vivo PDT.…”

Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

“…Scherman, Richard, and co-workers reported that the PeL of ZnGa 2 O 4 :Cr III can be restored using 808 nm excitation due to the UC excitation of the Cr III [ 48 ]. Yan and co-workers incubated the system ZnGa 2 O 4 :Cr III – Si-Pc in HepG2 cells for 8 h, and re-charged the PeL using 808 nm excitation pumps for 0, 3, 5, or 10 min that resulted in cell viability of almost 0 % (concentration = 200 μg × mL −1 ) proving the potentialities of using PeL-NPs in efficient PDT [ 276 ]. Although NIR radiation has a deeper penetration than to UV or visible wavelengths [ 61 , 63 ], it still cannot penetrate deeper tissues.…”

Section: Persistent Luminescence In Luminescence Imaging Of Biologmentioning

confidence: 99%

See 1 more Smart Citation

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

View full text Add to dashboard Cite

The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.

show abstract

“…[93][94][95][96][97] It generates reactive oxygen species (ROS) through photodynamic reaction and uses ROS to kill the tumour cells. 27,[98][99][100] In 2017, Huang and Chen et al used ZnGa 1.996 O 4 :Cr 0.004 3+ as a photodynamic excitation light source. 80 This VPLNP can be excited by white LED in vivo and the NIR emission can activate the photochlor 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbidea (HPPH).…”

Section: Application Of Vplnps In Biomedicinementioning

confidence: 99%