Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility

Grant, Dave; Benson, James D.; Cozad, Matthew J.; Whelove, Ona E.; Bachman, Sharon L.; Ramshaw, Bruce; Grant, David A.; Grant, Sheila

doi:10.1007/s10856-011-4449-6

Cited by 18 publications

(16 citation statements)

References 32 publications

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“…It should be noted that onset temperature corresponds to the beginning of the phase transition, and is not the same as the position of the peak on DSC. Typically, onset temperatures are reported in the literature for characterization of functional polymeric materials, including hernia meshes, since these parameters correlate better with the degree of crystallinity …”

Section: Discussionmentioning

confidence: 99%

In vitro study on the deterioration of polypropylene hernia repair meshes

et al. 2017

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Despite the relative safety of the procedure, hernia repairs are often associated with chronic post-operative pain. Although this complication has been linked among others to mesh deterioration, details of the processes that lead this deterioration are still unknown. This work aims to bridge this gap by analyzing the chemical, physical and structural alterations in hernia repair meshes exposed to oxidative stress in vitro. Here, we developed a methodology to characterize effect of oxidation stress on structure and properties of polymeric hernia repair meshes. It was shown that structural changes in polypropylene meshes exposed to oxidative stress may involve formation of cross-links between the polymer chains, chain scissions, and hydrogen bonds between the carboxyl groups, which are formed in the material during the oxidation. These effects result in mesh stiffening, ultimately leading to chronic post-operative pain. Moreover, we demonstrated that Composix meshes are more vulnerable to the oxidative stress when compared with UltraPro meshes. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2225-2234, 2018.

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Section: Discussionmentioning

confidence: 99%

In vitro study on the deterioration of polypropylene hernia repair meshes

et al. 2017

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“…Utilizing gold nanoparticles to improve collagen stability can lead to other benefits as well. Recent studies have shown that gold nanoparticles will enhance biocompatibility . For example, gold nanoparticles were entrapped within a poly(ether)urethane material, which led to improved cell adhesion and protein adsorption as well as reduced monocyte activation and bacterial adhesion .…”

Section: Introductionmentioning

confidence: 99%

“…For example, gold nanoparticles were entrapped within a poly(ether)urethane material, which led to improved cell adhesion and protein adsorption as well as reduced monocyte activation and bacterial adhesion . Other studies showed that gold nanoparticles crosslinked to polypropylene improved cellularity via cell culture assays . Still others have shown that proteins important for cell adhesion adsorb at higher concentrations on nanomaterials than on conventional materials .…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have shown that gold nanoparticles will enhance biocompatibility. [9][10][11] For example, gold nanoparticles were entrapped within a poly(ether)urethane material, which led to improved cell adhesion and protein adsorption as well as reduced monocyte activation and bacterial adhesion. 9 Other studies showed that gold nanoparticles crosslinked to Correspondence to: S. A.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the biocompatibility and stability of a gold nanoparticle collagen bioscaffold

Grant

Spradling

Grant

et al. 2013

J Biomedical Materials Res

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Collagen has been utilized as a scaffold for tissue engineering applications due to its many advantageous properties. However, collagen in its purified state is mechanically weak and prone to rapid degradation. To mitigate these effects, collagen can be crosslinked. Although enhanced mechanical properties and stability can be achieved by crosslinking, collagen can be rendered less biocompatible either due to changes in the overall microstructure or due to the cytotoxicity of the crosslinkers. We have investigated crosslinking collagen using gold nanoparticles (AuNPs) to enhance mechanical properties and resistance to degradation while also maintaining its natural microstructure and biocompatibility. Rat tail type I collagen was crosslinked with AuNPs using a zero-length crosslinker, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). Several characterization studies were performed including electron microscopy, collagenase assays, ROS assays, and biocompatibility assays. The results demonstrated that AuNP-collagen scaffolds had increased resistance to degradation as compared to non-AuNP-collagen while still maintaining an open microstructure. Although the biocompatibility assays showed that the collagen and AuNP-collagen scaffolds are biocompatible, the AuNP-collagen demonstrated enhanced cellularity and glycoaminoglycans (GAG) production over the collagen scaffolds. Additionally, the Reactive Oxygen Species (ROS) assays indicated the ability of the AuNP-collagen to reduce oxidation. Overall, the AuNP-collagen scaffolds demonstrated enhanced biocompatibility and stability over non-AuNP scaffolds.

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“…The collagen and elastin present in the patch matrix provides an organized scaffold for cells to adhere and proliferate [54]. In addition, the AuNPs as shown in Figure 4e have been shown to increase stability, decrease inflammation, and slow down scaffold degradation as demonstrated in earlier in vitro studies [30, 31, 34, 55–57]. The lack of thrombosis and other inflammatory and immune reactions may indicate that the patches’ surface modifications are aiding in the host integration process.…”

Section: Discussionmentioning

confidence: 95%

An in vivo study of a gold nanocomposite biomaterial for vascular repair

et al. 2015

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Currently vascular repairs are treated using synthetic or biologic patches, however these patches have an array of complications, including calcification, rupture, re-stenosis, and intimal hyperplasia. An active patch material composed of decellulzarized tissue conjugated to gold nanoparticles (AuNPs) was developed and the long term biocompatibility and cellular integration was investigated. Porcine abdominal aortic tissue was decellularized and conjugated with 100nm gold nanoparticles (AuNP). These patches were placed over a longitudinal arteriotomy of the thoracic aorta in six pigs. The animals were monitored for six months. Gross, histological, and immunohistochemical analyses of the patches were performed after euthanasia. Grossly there was minimal scar tissue with the patches still visible on the outer surface of the vessel. The inner lumen was smooth with a seamless transition from patch to native tissue. Histology demonstrated infiltration of host cells into the patch material. The immunohistochemical results demonstrated an endothelial cell layer forming over the patch within the vessel. Smooth muscle cells were repopulating the biomaterial in all animals. These results demonstrated that the AuNP biomaterial patch integrated well with the host tissue and did not failed over the six month implantation time.

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Conjugation of gold nanoparticles to polypropylene mesh for enhanced biocompatibility

Cited by 18 publications

References 32 publications

In vitro study on the deterioration of polypropylene hernia repair meshes

In vitro study on the deterioration of polypropylene hernia repair meshes

Assessment of the biocompatibility and stability of a gold nanoparticle collagen bioscaffold

An in vivo study of a gold nanocomposite biomaterial for vascular repair

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