Conjunctival Pigmented Epithelioid Melanocytoma: A Clinicopathological Case Report

Bissig, A.; Moulin, Alexandre; Spahn, B.; Zembowicz, Artur; Schalenbourg, Ann

doi:10.1001/archophthalmol.2012.1476

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…While PEM involving the conjunctiva has been reported [1], this is the first report of orbital involvement with satellite lesions. The young age of the patient, along with the size, multifocality, and growth of this lesion, makes it a unique case.…”

Section: Discussionmentioning

confidence: 94%

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Pigmented Epithelioid Melanocytoma of the Cheek, Orbit, and Intracranial Cavity: A Case Report

et al. 2017

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Pigmented epithelioid melanocytoma (PEM) of the skin has been rarely reported in ophthalmology. The purpose of this case report is to present a young male born with a progressive, hyperpigmented lesion involving the orbit and intracranial cavity diagnosed as PEM. The case is unique given the young age and the size, multifocality, and growth of this tumor. Identification of this lesion is paramount due to its low-grade malignant potential.

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Section: Discussionmentioning

confidence: 94%

“…Pigmented epithelioid melanocytoma (PEM) of the skin has been rarely reported in ophthalmology [1]. The term “melanocytoma” itself can refer to indeterminate melanocytic lesions not belonging to any tumor classification.…”

Section: Introductionmentioning

confidence: 99%

Pigmented Epithelioid Melanocytoma of the Cheek, Orbit, and Intracranial Cavity: A Case Report

et al. 2017

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“…In contrast to ocular melanocytoma, skin lesions termed “pigmented epithelioid melanocytoma” comprise a group of lesions including cases previously diagnosed as animal-type melanoma and epithelioid blue nevus, and they are best considered as borderline melanocytic neoplasms or low-grade melanomas [12, 13]. Their clinical behavior, as well as their histological appearance, differs from that of genuine melanocytomas of the nervous system, and the term pigmented epithelioid melanocytoma is rather misleading.…”

Section: Discussionmentioning

confidence: 99%

Melanocytoma of the Conjunctiva: Clinicopathologic Features of Three Cases

2019

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Background: Melanocytoma (magnocellular nevus) is a jet-black benign lesion histologically composed of polygonal tumor cells with small, inconspicuous nuclei and abundant cytoplasm. Melanocytomas in general are rare. Most cases occur in the optic nerve head. Conjunctival melanocytoma (magnocellular nevus) is extremely rare, and only 3 lesions of the ocular surface have been reported. Objectives: To describe the clinical and histological spectrum of conjunctival melanocytoma and discuss differential diagnoses of this rare lesion. Method: Four heavily pigmented conjunctival lesions were excised for slight tumor growth and histologically processed. The specimens were routinely stained with hematoxylin and eosin and periodic acid-Schiff. Sections were bleached and immunohistochemical stains were performed for CD68, HMB-45, S100, melanin, and Ki-67. Results: Histological examination revealed findings of a conjunctival melanocytoma in 3 cases. The fourth case was diagnosed histologically as a combined melanocytic lesion with a compound nevus and an inverted type A nevus. None of the lesions exhibited transition towards malignancy. The differential diagnoses included conjunctival melanoma, granular cell nevus, compound nevus with reactive changes, and blue nevus. Conclusions: Conjunctival melanocytic lesions suspicious for melanocytoma should be bleached to evaluate their cytologic features. CD68 can be helpful in identifying heavily pigmented melanomacrophages which may mimic a melanocytoma. As conjunctival melanocytomas are extremely rare, their pathogenesis may be different from that of other conjunctival nevi.

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“…Rare cases of ATM have been described on the skin of genitalia as reported on a newborn on left major labium (Ref 22). Mucosal localisation of ATM has also been described on the tarsal conjunctive (Ref 23) as oral mucosal lentiginous melanoma with prominent pigment synthesis (Ref 24), or similar to the typical Ota nevus in the sclera (Ref 25).…”

Section: Review Of the Literaturementioning

confidence: 99%

Animal-type melanoma: dog or wolf? A review of the literature and a case report

Stucci

Palmirotta

Lovero

et al. 2018

Expert Rev. Mol. Med.

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The human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more common melanocytic lesions, as well as for its peculiar biological behaviour. On the other hand, the contribution of scientific literature to this issue is fragmented and limited to the description of very few cases. Starting from the presentation of a case with abnormally aggressive clinical features, here we revisit the current knowledge on ATM from its dermatologic patterns, epidemiology, demography and histopathology to the clinical management. Peculiar accuracy has also been reserved to several histopathologic criteria, which are critical for the differential diagnosis from other melanocytic diseases in junction with molecular data deriving from recent cytogenetic and mutational characterisation of this tumour.

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Conjunctival Pigmented Epithelioid Melanocytoma: A Clinicopathological Case Report

Cited by 13 publications

References 5 publications

Pigmented Epithelioid Melanocytoma of the Cheek, Orbit, and Intracranial Cavity: A Case Report

Pigmented Epithelioid Melanocytoma of the Cheek, Orbit, and Intracranial Cavity: A Case Report

Melanocytoma of the Conjunctiva: Clinicopathologic Features of Three Cases

Animal-type melanoma: dog or wolf? A review of the literature and a case report

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