Conjunctival Squamous Cell Carcinoma Arising in Immunosuppressed Patients (Organ Transplant, Human Immunodeficiency Virus Infection)

Shields, Carol L.; Ramasubramanian, Aparna; Mellen, Phoebe L.; Shields, Jerry A.

doi:10.1016/j.ophtha.2011.04.001

Cited by 82 publications

(59 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Its causation is multifactorial but OSSN has been associated with older age, male gender, cigarette smoking, UV-B light exposure, fair complexion, HPV and HIV infections, and immunosuppression [2-5]. Depending on the clinical stage of disease, treatment options include surgical excision with or without irradiation or cryotherapy, photodynamic therapy, topical chemotherapy, immunotherapy, and antivirals [1, 6-10].…”

Section: Introductionmentioning

confidence: 99%

Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b

et al. 2018

View full text Add to dashboard Cite

Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. Cases: Two patients with 360 degrees of limbal involvement. Results: Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy. Conclusion: Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.

show abstract

Section: Introductionmentioning

confidence: 99%

Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b

et al. 2018

View full text Add to dashboard Cite

show abstract

“…1 However, the present case is the first isolated OSSN without skin carcinoma in KT recipients after long-term tacrolimus treatment. [1][2][3]6 In this male patient, there is no skin cancer after three years follow-up. OSSN, which is considered to be a low-grade malignancy, usually tends to recur within 2 years.…”

Section: Discussionmentioning

confidence: 62%

Isolated Ocular Surface Squamous Neoplasia in a Renal Transplant Recipient

Aktaş¹,

Yazıcı²,

Kilic³

et al. 2012

Exp Clin Transplant

View full text Add to dashboard Cite

Ocular surface squamous neoplasia is a rare complication after a kidney transplant, related with increased risk and poor prognosis. Generally, ocular surface squamous neoplasia in kidney transplant patients is associated with skin lesions. We report a case of ocular surface squamous neoplasia without skin lesions in a kidney transplant recipient. Systematic periodic ophthalmic evaluation of recipients may help ensure the early diagnosis of subtle ocular surface squamous neoplasia.

show abstract

“…A definitive diagnosis of pterygium versus OSSN can only be made by histopathology, thus we recommend performing histopathology studies for all pterygium specimens. Variants including mucoepidermoid, spindle cell, and OSSN associated with immunosuppression or HIV coinfection should be suspected in aggressive clinical presentations, massive tumors, and recurrent manifestations [33,36]. The difference in reported OSSN rates in clinically benign pterygium may be due to the wide variation in thresholds for grading squamous dysplasia between pathologists and institutions [20].…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

Mendoza¹,

Craven

et al. 2018

Ocul Oncol Pathol

View full text Add to dashboard Cite

Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion. Methods: Retrospective, clinicopathologic case series. Results: All patients had prior resections of presumed pterygia. The degree of corneal involvement dictated the extent of surgical management. One eye with localized invasion was treated with lamellar keratoplasty and plaque brachytherapy. Another case with widespread invasion warranted penetrating keratoplasty and eventual enucleation. Two cases were treated medically prior to surgical intervention: one with localized invasion was treated with topical interferon and retinoic acid; another with significant inflammation was treated with doxycycline and fluorometholone. The patient who underwent keratoplasty and brachytherapy had no recurrence after 7 years of follow-up. Those initially treated medically had resections of recurrence but ultimately required enucleation. Histologically, specimens demonstrated SCC invading the deep corneal stroma, with 2 tumors of the mucoepidermoid type. Conclusions: This series demonstrates the importance of maintaining clinical suspicion of conjunctival squamous neoplasia in pterygia. We recommend that all excised pterygia be submitted for histopathologic evaluation and be carefully evaluated for dysplasia and variants of SCC associated with increased risk of intraocular invasion. Undetected ocular surface squamous neoplasia may give rise to potentially vision- and eye-threatening invasive corneal SCC.

show abstract

Conjunctival Squamous Cell Carcinoma Arising in Immunosuppressed Patients (Organ Transplant, Human Immunodeficiency Virus Infection)

Cited by 82 publications

References 14 publications

Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b

Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b

Isolated Ocular Surface Squamous Neoplasia in a Renal Transplant Recipient

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

Contact Info

Product

Resources

About