Connecting the public with clinical trial options: The ResearchMatch Trials Today tool

Pulley, Jill M.; Jerome, Rebecca N; Bernard, Gordon R.; Olson, Erik J.; Tan, Jason; Wilkins, Consuelo H.; Harris, Paul A.

doi:10.1017/cts.2018.327

Cited by 16 publications

(9 citation statements)

References 20 publications

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“…This research can be considered an initial step toward a broader understanding of researcher use of web portals for clinical research requiring researcher-authored content such as the one used in this study as well as portals that repurpose registry content for recruitment of volunteers into clinical trials. 26,27…”

Section: Discussionmentioning

confidence: 99%

Researcher Perceptions of a Self-Service Online Portal to Facilitate Volunteer Recruitment into Clinical Trials

et al. 2021

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Background Recruitment of volunteers is a major challenge for clinical trials. There has been increasing development and use of Internet-based portals in recruitment for clinical research. There has been little research on researcher use and perceptions of these portals. Objectives This study evaluated researcher perceptions of use of Rally, an Internet-based portal for clinical trial volunteer recruitment. Methods A cross-sectional survey was developed and implemented to understand researcher perceptions. From theoretical models of information technology use, the survey adopted items in four domains: ease of use, usefulness, facilitating conditions, and self-efficacy. The dependent variable was researchers' behavioral intention to use Rally. The survey captured characteristics of researchers such as gender, age, and role. It was implemented using the REDCap survey tool. An email invitation followed by three reminders was sent to researchers. A hierarchical regression model was applied to assess predictors of behavioral intention. Results The survey response rate was 35.6% (152 surveys received from 427 contacted researchers). In the hierarchical regression model, facilitating conditions and self-efficacy predicted behavioral intention (F (4,94) = 6.478; p <0.001). The model explained 21.6% of the variance in behavioral intention (R-square change = 21.3%, p <0.001). Conclusion Facilitating conditions and self-efficacy predicted researchers' behavioral intention to use Rally for volunteer recruitment into clinical trials. Future research should document best practices and strategies for enhancing researcher use of online portals for volunteer recruitment.

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Section: Discussionmentioning

confidence: 99%

Researcher Perceptions of a Self-Service Online Portal to Facilitate Volunteer Recruitment into Clinical Trials

et al. 2021

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“…Patients with laboratory-confirmed SARS-CoV-2 infection with self-reported symptom severity of at least 3 on a 10-point scale (range: 1, “I feel healthy” to 10, “I was/should have been in the Intensive Care Unit (ICU)”) are eligible for plasma donation. Recovered patients are identified through several methods including Vanderbilt hospital records, mass email through the Vanderbilt employee list, public advertising in the community, Research-Match [ 29 , 30 ], and self-identification. Patients are able to donate plasma if they have recovered from acute COVID-19, defined as either: (1) being symptom-free for 14 days and having at least one negative COVID-19 test by RT-PCR, or (2) being symptom-free for at least 28 days.…”

Section: Methodsmentioning

confidence: 99%

Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults

Self

Stewart

Wheeler

et al. 2021

Trials

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Background Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent plasma is unclear. Methods The Passive Immunity Trial for Our Nation (PassITON) is a multicenter, placebo-controlled, blinded, randomized clinical trial being conducted in the USA to provide high-quality evidence on the efficacy of COVID-19 convalescent plasma as a treatment for adults hospitalized with symptomatic disease. Adults hospitalized with COVID-19 with respiratory symptoms for less than 14 days are eligible. Enrolled patients are randomized in a 1:1 ratio to 1 unit (200–399 mL) of COVID-19 convalescent plasma that has demonstrated neutralizing function using a SARS-CoV-2 chimeric virus neutralization assay. Study treatments are administered in a blinded fashion and patients are followed for 28 days. The primary outcome is clinical status 14 days after study treatment as measured on a 7-category ordinal scale assessing mortality, respiratory support, and return to normal activities of daily living. Key secondary outcomes include mortality and oxygen-free days. The trial is projected to enroll 1000 patients and is designed to detect an odds ratio ≤ 0.73 for the primary outcome. Discussion This trial will provide the most robust data available to date on the efficacy of COVID-19 convalescent plasma for the treatment of adults hospitalized with acute moderate to severe COVID-19. These data will be useful to guide the treatment of COVID-19 patients in the current pandemic and for informing decisions about whether developing a standardized infrastructure for collecting and disseminating convalescent plasma to prepare for future viral pandemics is indicated. Trial registration ClinicalTrials.gov NCT04362176. Registered on 24 April 2020.

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“…Promotion of clinical trials increases awareness of opportunities for research participation related to an individual's personal needs. The RIC has worked to increase clinical trial awareness nationally with Trials Today, 11 a novel public-facing interface that helps patients and families search for relevant clinical trials. Launched in 2015 and partially supported by the RIC, the site resides within the ResearchMatch volunteer platform (described later) and uses ClinicalTrials.gov data.…”

Section: General Awarenessmentioning

confidence: 99%

The Recruitment Innovation Center: Developing novel, person-centered strategies for clinical trial recruitment and retention

Wilkins

Edwards²,

Stroud³

et al. 2021

J. Clin. Trans. Sci.

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Connecting the public with clinical trial options: The ResearchMatch Trials Today tool

Cited by 16 publications

References 20 publications

Researcher Perceptions of a Self-Service Online Portal to Facilitate Volunteer Recruitment into Clinical Trials

Researcher Perceptions of a Self-Service Online Portal to Facilitate Volunteer Recruitment into Clinical Trials

Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults

The Recruitment Innovation Center: Developing novel, person-centered strategies for clinical trial recruitment and retention

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