Given complex parameters x, ν, α, β and γ / ∈ −N, consider the infinite lower triangular matrix A(x, ν; α, β, γ) with elementsfor 1 k n, depending on the Hypergeometric polynomials F (−n, •; •; x), n ∈ N * . After stating a general criterion for the inversion of infinite matrices in terms of associated generating functions, we prove that the inverse matrix B(x, ν; α, β, γ) = A(x, ν; α, β, γ) −1 is given by