Connective Tissue Disease and Autoantibodies in the Kindreds of 63 Patients with Systemic Sclerosis

Maddison, Peter J.; Stephens, Clare; Briggs, David; Welsh, Ken I.; Harvey, Georgina; Whyte, Jean; McHugh, Neil; Black, Carol M.

doi:10.1097/00005792-199303000-00004

Cited by 48 publications

(24 citation statements)

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“…Nevertheless, among the 38 uranium miners with definite SSc, the ATA frequency is still higher (42.1%) compared to idiopathic SSc. This difference may not be gender-related (most of the patients with idiopathic SSc are women) since ATA was found equally among males and females in other studies [35,36]. Variations in genetic determinants may result in different responses to different triggering mechanisms.…”

Section: Diagnostic and Prognostic Relevance Of Aab Typical Of Ctd Inmentioning

confidence: 84%

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Conrad¹,

Mehlhorn²

2000

Int Arch Allergy Immunol

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Uranium miners exposed to silica dust have a higher risk of developing systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). Sera of 1976 former uranium miners were analysed for autoantibodies typical of connective tissue disease. The frequency of some of these antibodies (anti-centromere, -topoisomerase I, -nucleolar, -dsDNA, -Ro/SSA, -La-SSB and U1-RNP antibodies) was significantly higher compared to a gender- and age-matched control group and was associated with the intensity of exposure as well as with clinical symptoms of SSc or SLE. It was also shown that SSc-associated autoantibodies may serve as an early indicator of disease development. Some differences in the autoantibody production between silica-dust-associated and idiopathic SLE/SSc were observed that might be caused by environmental factors in the population of uranium miners.

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Section: Diagnostic and Prognostic Relevance Of Aab Typical Of Ctd Inmentioning

confidence: 84%

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Conrad¹,

Mehlhorn²

2000

Int Arch Allergy Immunol

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“…It appears that HLA associations in SSc may be more involved with disease susceptibility, because of a substantially stronger HLA association with autoantibody profiles than with the disease itself (64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74).…”

Section: T Cell Receptors (Tcrs) In Sscmentioning

confidence: 99%

Is systemic sclerosis an antigen‐driven T cell disease?

Sakkas¹,

Platsoucas²

2004

Arthritis & Rheumatism

113

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“…218 first degree relatives and 22 spouses, as part of a multi-centre study of SSc organized by the UK Scleroderma Study Group [16]. Three families were from the USA, two were from Russia, and the remaining families were from the UK.…”

Section: Systemic Nlerosis Familiesmentioning

confidence: 99%

“…Thus an increased frequency of HLA-DRI [1. [15][16][17], HLA-DR4 [15] and HLA-DRwK [15] has been reported for ACA. and an increased frequency of HLA-DR5 [1,15] and HLA-DR2 [IH] for ATA.…”

Section: Introductionmentioning

confidence: 99%

Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study

McHugh

Whyte

Artlett

et al. 1994

Clinical and Experimental Immunology

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SUMMARYAutoantibody reaclivily to cenlromere prolcins CENP-A. CENP-B and CENP-C was examined in 58 patienls with systemic sclerosis (SSc). 218 first degree relatives and 22 spouses, HLA class II typing for HLA-DRBI and HLA-DQAI was performed by reslriction fragment lenglh polymorphism (RFLP) analysis in 50 families, and HLA-DRBI, HLA-DQAI and HLA-DQBl typing was performed by olignueleolitlc typing in 44 families. Eleven probands and two relatives had ACA. The two relatives with ACA also had SSc. One relative was an identical twin sister of a proband with ACA and Iheother relative was a sister of a proband with ACA. All ACA-positivc probands and relatives were female, and all recognized CENP-A. CENP-B and CENP-C. The presence of at least one HLADQBl allele not coding for leueine at position 26 of the first domain appeared nceessary. although not sufficient for the generation of ACA, Therefore within SSc families ACA is strongly associated with female gender and disease phenolype, and is at least in part genetically determined.

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Connective Tissue Disease and Autoantibodies in the Kindreds of 63 Patients with Systemic Sclerosis

Cited by 48 publications

References 0 publications

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Is systemic sclerosis an antigen‐driven T cell disease?

Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study

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