Connective Tissue Disease in Southeastern Georgia: A Case-Control Study of Etiologic Factors

Freni-Titulaer, Lambertina W.; Kelley, Delle B.; Grow, Adam G.; McKinley, Thomas W.; Arnett, Frank C.; Hochberg, Marc C.

doi:10.1093/oxfordjournals.aje.a115348

Cited by 63 publications

(29 citation statements)

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“…We used the matched case-control data set to assess the construct validity of our study design. We tested for associations with a panel of factors documented in prior studies to be associated with SLE, including herpes zoster [6,7,34,35], urticaria [6,9], allergy to sulfonamides [10][11][12], and miscarriage [5]. Our analyses demonstrated associations that were consistent with prior studies and showed strong concordance with respect to effect size.…”

Section: Discussionsupporting

confidence: 58%

“…Participants completed an online questionnaire about demographic factors, medications, comorbidities, common exposures, and a panel of factors consistently associated with SLE (miscarriage [5], shingles [6][7][8], hives [6,9], and allergy to sulfonamides [10][11][12][13]). We used standardized questions derived from previous studies [2,14].…”

Section: The Questionnairementioning

confidence: 99%

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Feasibility and validity were demonstrated of an online case–control study using the prototype of recent-onset systemic lupus erythematosus

McAlindon

Wang

Formica

et al. 2008

Journal of Clinical Epidemiology

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Objective-To test the feasibility and validity of the online case-control study design through the empirical deployment of a prototype study of recent-onset systemic lupus erythematosus (SLE).Study Design and Setting-We conducted an Internet-based case-control study of SLE during [2003][2004][2005]. The source population comprised Google users searching on medical key terms, solicited using sponsored links. Cases fulfilled a self-administered algorithm for SLE diagnosed within 5 years. A subset underwent confirmation by medical record review. Controls were matched to cases using a propensity score.Results-Four hundred and two cases and 693 control applicants finished the questionnaires, yielding 389 matched case-control pairs. Eighty-two percentage of the records documented a clinical diagnosis of SLE, and 61% documented ≥4 American College of Rheumatology criteria for SLE. Control applicants resembled Internet users, with the exceptions of comprising more women (86% vs. 52%) and fewer minority individuals (e.g., 5% vs. 9% for African-Americans). There was a broad representation of clinical manifestations. SLE was associated with miscarriage (odds ratio [OR] = 3.0, 95% confidence interval [CI] = 2.0-4.7), allergy to sulfonamides (OR = 2.2, CI = 1.5-3.2), hives (OR = 1.9, CI = 1.4-2.5), and shingles (OR = 2.3, CI = 1.4-3.7).Conclusion-It is possible to perform case-control studies over the Internet using an internally valid design, obtain reliable information from participants, and confirm established associations.

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Section: Discussionsupporting

confidence: 58%

Section: The Questionnairementioning

confidence: 99%

Feasibility and validity were demonstrated of an online case–control study using the prototype of recent-onset systemic lupus erythematosus

McAlindon

Wang

Formica

et al. 2008

Journal of Clinical Epidemiology

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“…Those who reported augmentation mammoplasty were asked the year of the procedure, information on the subsequent development of complications, and the year of and indication for explantation, if it occurred. The questionnaire included items from one that had been previously used in a population-based study of factors associated with connective tissue disease (30), with supplementary questions on augmentation mammoplasty that were reviewed by a group of plastic and reconstructive surgeons.…”

Section: Methodsmentioning

confidence: 99%

Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma)

Hochberg

Perlmutter

Medsger

et al. 1996

Arthritis & Rheumatism

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Objective.To examine the possible association between augmentation mammoplasty and systemic sclerosis (SSc; scleroderma).Methods. Eight hundred thirty-seven women with a clinical diagnosis of SSc, recruited as a volunteer sample from 3 university-based, tertiary care scleroderma clinical research centers, and 2,507 race-matched local control women, recruited by the technique of random-digit-dialing and frequency-matched on age, completed a questionnaire providing data on history of augmentation mammoplasty, including possible complications of the procedure. The odds ratio (OR) and 95 percent confidence interval (95% CI) for the association of augmentation mammoplasty with SSc were estimated Presented in part at the 56th National Meeting of the American College of Rheumatology, .4tlanta, GA, October 1 9 2 , the 57th National Meeting of the American College of Rheumatology, San Antonio, TX, November 1993 by multivariate logistic regression analysis with adjustment for age, race and center, and by conditional logistic regression analysis with adjustment for age.Results. Eleven (131%) of the 837 cases reported a history of augmentation mammoplasty prior to diagnosis of SSc, compared with 31 (1.24%) of the 2,507 controls. The adjusted OR from the unmatched analysis was 1.07 (95% CI 0.53-2.13), while that from the matched analysis was 1.11 (95% CI 0.55-2.24). Conclusion.These results fail to demonstrate a significant association between augmentation mammoplasty and SSc, and are consistent with those reported from other epidemiologic studies.Thirty years ago, Miyoshi and colleagues published the first report of patients with a presumed connective tissue disease following cosmetic breast augmentation by direct injection of liquid paraffin and silicone (1). In 1984, Kumagai and colleagues described 11 patients with definite connective tissue disease and 7 with possible connective tissue disease and reviewed 28 additional cases from the Japanese literature (2). All of these patients had breast augmentation by injection of a foreign substance, most commonly paraffin or silicone, and 8 had a diagnosis of systemic sclerosis (SSc; scleroderma). The first report of patients developing definite connective tissue disease following augmentation mammoplasty with silicone gel-filled breast implants was presented by van Nunen and colleagues in 1982 (3). Numerous case reports and case series describing patients with rheumatic disease symptoms and connective tissue diseases following augmentation mammoplasty with silicone gel-filled breast implants were published during the ensuing decade (4-20). In a review of the English-language literature published from 1979 through June 1993, Sanchez-Guerrero and colleagues identified reports of 293 patients with rheumatic disease symptoms following augmentation mammoplasty with silicone gel-filled breast implants; of 57 patients with a 1126 HOCHBERG ET AL definite connective tissue disease, 38 (66.7%) had a diagnosis of SSc (21). Subsequent to that review, data on 376 patients with rheumatic sy...

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“…25,26,29 Está bien reconocido el efecto del sexo sobre la susceptibilidad para ciertas enfermedades autoinmunes. En el LES existe un claro efecto de las hormonas sexuales femeninas en el desarrollo y evolución del LES.…”

Section: No3 Mayo-junio De 2002unclassified

“…[25][26][27][28][29][30][31] Tres de estos estudios 26,28,30 tuvieron menos de 100 casos, lo cual limita el poder estadístico, y en otro 26 los casos tenían más de 10 años de evolución, lo cual afecta la calidad de la información evaluada. El objetivo del presente trabajo fue determinar la asociación de factores de riesgo y el desarrollo de LES, con un estudio de casos y controles en población mexicana.…”

Section: Introductionunclassified

Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana

et al. 2002

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Connective Tissue Disease in Southeastern Georgia: A Case-Control Study of Etiologic Factors

Cited by 63 publications

References 0 publications

Feasibility and validity were demonstrated of an online case–control study using the prototype of recent-onset systemic lupus erythematosus

Feasibility and validity were demonstrated of an online case–control study using the prototype of recent-onset systemic lupus erythematosus

Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma)

Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana

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