2014
DOI: 10.1016/j.neuroimage.2013.09.009
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Connectivity patterns of pallidal DBS electrodes in focal dystonia: A diffusion tensor tractography study

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Cited by 46 publications
(42 citation statements)
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“…Moreover, the clinically effective contacts (0 and 1 in our patient) did target projections to cortical areas previously identified to be involved in dystonia, like the primary motor and sensory cortex [57]. Unilateral pallidal DBS provided considerable clinical improvement, in this patient with asymmetric presentation, as expected and supported by stronger connectivity in the right hemisphere.…”
Section: Discussionsupporting
confidence: 73%
“…Moreover, the clinically effective contacts (0 and 1 in our patient) did target projections to cortical areas previously identified to be involved in dystonia, like the primary motor and sensory cortex [57]. Unilateral pallidal DBS provided considerable clinical improvement, in this patient with asymmetric presentation, as expected and supported by stronger connectivity in the right hemisphere.…”
Section: Discussionsupporting
confidence: 73%
“…These findings comport well with previous reports that dystonia is not only a motor disorder, but also involves sensory symptoms [Tinazzi et al, ]. Rozanski et al also showed that the ventral globus pallidus internus, a location at which deep brain stimulation is effective for alleviating dystonia symptoms, is significantly connected to the primary somatosensory cortex [Rozanski et al, ]. Together with prior observations that (i) deficient sensorimotor integration is characteristic of individuals with dystonia [Abbruzzese and Berardelli, ], (ii) somatosensory alterations extend beyond the representation of the dystonic limb [Meunier et al, ], (iii) sensory inputs may modulate dystonic symptoms (sensory trick) [Naumann et al, ], and (iv) abnormalities of sensory processing are observed in unaffected relatives of individuals with dystonia [Walsh et al, ], the present results support the view point that somatosensory dysfunction represents a primary trait of dystonia [Meunier et al, ; Walsh et al, ].…”
Section: Discussionmentioning
confidence: 96%
“…Dystonic patients show increased connectivity from the posterior part of the globus pallidus to motor and premotor regions (Rozanski et al. ). It is conceivable that as a result of impaired movement automatization, writer's cramp patients need more cognitive elements to perform complex motor tasks.…”
Section: Discussionmentioning
confidence: 99%