Consequences of Fluoride Incorporation on Properties of Apatites

LeGeros, Racquel Z.; Mijares, Dindo Q.; Yao, Fen; LeGeros, John P.; Bromage, Timothy; La, Vale-Silva; Xi, Qing; Tannous, Samar; Kijkowska, Regina

doi:10.4028/www.scientific.net/kem.309-311.697

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…This recrystallization process occurs simultaneously with collagen degradation in bones exposed on soil surfaces (Tuross et al 1989;Trueman et al 2004) and is accompanied by incorporation of various ions in the apatite matrix via diffusion or ion exchange (Pate et al 1989;Kohn 2008;Trueman 2008). Chemical alterations such as substitution of OHby Fand reduction of carbonate content increase the apatite crystallinity and provide greater chemical stability (LeGeros and Tung 1983;LeGeros et al 2006) while the geochemical conditions of the deposition site, as for example waterlogged areas (Reiche et al 2002), can also affect the size of the apatite crystals in sub-fossil bone, resulting in sizes comparable to that in fossil bones. Therefore, the apatite crystallinity depends on many factors such as the amount of preserved collagen, the sediment pH and redox potential, hydrology and solution composition, the bone porosity, the microbial activity, exposure on soil surface and the pre-burial environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Ca L2,3-edge XANES and Sr K-edge EXAFS study of hydroxyapatite and fossil bone apatite

Zougrou

Katsikini

Brzhezinskaya

et al. 2016

Sci Nat

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Upon burial, the organic and inorganic components of hard tissues such as bone, teeth, and tusks are subjected to various alterations as a result of interactions with the chemical milieu of soil, groundwater, and presence of microorganisms. In this study, simulation of the Ca L 2,3-edge X-ray absorption near edge structure (XANES) spectrum of hydroxyapatite, using the CTM4XAS code, reveals that the different symmetry of the two nonequivalent Ca(1) and Ca(2) sites in the unit cell gives rise to specific spectral features. Moreover, Ca L 2,3-edge XANES spectroscopy is applied in order to assess variations in fossil bone apatite crystallinity due to heavy bacterial alteration and catastrophic mineral dissolution, compared to well-preserved fossil apatite, fresh bone, and geologic apatite reference samples. Fossilization-induced chemical alterations are investigated by means of Ca L 2,3-edge XANES and scanning electron microscopy (SEM) and are related to histological evaluation using optical microscopy images. Finally, the variations in the bonding environment of Sr and its preference for substitution in the Ca(1) or Ca(2) sites upon increasing the Sr/Ca ratio is assessed by Sr K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy.

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Section: Introductionmentioning

confidence: 99%

Ca L2,3-edge XANES and Sr K-edge EXAFS study of hydroxyapatite and fossil bone apatite

Zougrou

Katsikini

Brzhezinskaya

et al. 2016

Sci Nat

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“…Third, in contrast to polymers, the chemistry or topography of which can be, to a certain extent, tuned individually without affecting the other parameters, the properties of ceramic materials are difficult to control independently during the synthesis process . For example, it is very difficult to change the chemical composition of CaPs without affecting their crystal structure or morphology, or the micropore size without changing the total porosity . Therefore, any experiment designed to correlate the effect of an individual property with a certain biological response is largely affected by this entanglement of the properties ( Figure ).…”

Section: Introductionmentioning

confidence: 99%

Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

Galván-Chacón

Habibović

2017

Adv Healthcare Materials

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Calcium phosphate (CaP)-based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico-chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial-and-error approach to a design-driven approach in the development of new functional biomaterials. This progress report critically reviews various strategies developed to decouple the roles of the individual material properties in the biological performance of CaP ceramics. It furthermore emphasizes on the importance of a comprehensive and adequate material characterization that is needed to enhance our knowledge of the property-function relationship of biomaterials used in bone regeneration, and in regenerative medicine in general.

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“…In hydroxyapatite structure, PO 3− 4 anions can be partially substituted with carbonate group-type B of carbonated hydroxyapatite-as opposed to type A of high-temperature carbonated hydroxyapatite, in which hydroxyl groups are partially substituted with CO 2− 3 (LeGeros et al 1968(LeGeros et al , 1971Suetsugu et al 1997;Rajabi-Zamani et al 2008). Substitutions in anionic sublattice with other chemical elements such as chlorine or fluorine are common (LeGeros 1991;LeGeros et al 2006). Calcium partially substituted with magnesium (0•7 wt%), sodium (0•9 wt%), potassium (0•03 wt%) and microelements such as Sr, Pb, Zn, Cu and Fe have also been found (LeGeros et al 1989;1995a, b;Veiderma et al 2005;Kalita and Bhatt 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Calcium partially substituted with magnesium (0•7 wt%), sodium (0•9 wt%), potassium (0•03 wt%) and microelements such as Sr, Pb, Zn, Cu and Fe have also been found (LeGeros et al 1989;1995a, b;Veiderma et al 2005;Kalita and Bhatt 2007). The non-stoichiometry, particularly Ca-deficiency, as well as the presence of foreign ions, affect properties of hydroxyapatite such as reduction in crystal size (crystallinity), increase in solubility related to resorbability if the material has been implanted in human system, thermal stability is essential for elaboration of HAp based materials for further medical purpose, etc (Jarcho 1976;LeGeros 1991;Raynaud et al 1998Raynaud et al , 2002De Champos and Bressiani 2002;LeGeros et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Effect of calcination conditions of pork bone sludge on behaviour of hydroxyapatite in simulated body fluid

Sobczak-Kupiec

Wzorek

Kijkowska³

et al. 2013

Bull Mater Sci

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The paper presents in vitro (in SBF) behaviour of hydroxyapatite (HAp) obtained from pork bone sludge from meat plant via two essentially different calcination methods using a stationary, electrically heated chamber oven and enlarged laboratory scale rotary kiln designed by the authors, heated by gas combustion methods enabling application of different set of physical parameters such as temperature, holding time-differing according to type of the kiln. HAp ceramic discs, after 62-days of incubation in SBF at 37 • C, characterized by X-ray diffraction (XRD), FTIR, SEM and EDS methods, underwent changes recorded by: (i) a reduction in Ca/P molar ratio in all the investigated materials resulting from modification in phase composition and (ii) weight increase in the investigated disc-samples, resulting from a precipitation of newly formed phase as an admixture of primary HPO 2− 4-free HAp. They were: secondary (with HPO 2− 4 incorporated) HAp and chlorapatite in all the samples, while in addition to the listed above, β-tricalcium phosphate was formed on the discs made of HAp from stationary chamber oven, but not from rotary kiln. The new phases were formed in agglomerates on the surface of the investigated ceramic discs and in their pores. The results obtained proved that calcination conditions of pork bone sludge (temperature 750-950 • C, time and type of the applied kiln) under which hydroxyapatite (HAp) powders were obtained had an impact on its different behaviour in SBF, nevertheless, indicating a potential ability of the material to form a new biologically relevant interface with hard tissue and suitability for further investigations intended for medical grafting.

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Consequences of Fluoride Incorporation on Properties of Apatites

Cited by 4 publications

References 9 publications

Ca L2,3-edge XANES and Sr K-edge EXAFS study of hydroxyapatite and fossil bone apatite

Ca L2,3-edge XANES and Sr K-edge EXAFS study of hydroxyapatite and fossil bone apatite

Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

Effect of calcination conditions of pork bone sludge on behaviour of hydroxyapatite in simulated body fluid

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