Consequences of lead exposure, and it’s emerging role as an epigenetic modifier in the aging brain

Eid, Aseel; Zawia, Nasser H.

doi:10.1016/j.neuro.2016.04.006

Cited by 91 publications

(47 citation statements)

References 117 publications

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“…Brain is affected by metals' overload because most of these metals are cumulated in brain tissues, with alteration of cerebral function mostly in young patients with cognitive deficits. Thus, lead exposure and toxicity involve neurodegenerative diseases, particularly Alzheimer and Parkinson diseases [20]. Our experimental study reveals antagonistic effect of lead on iron in brain.…”

Section: Resultsmentioning

confidence: 69%

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

Nicula¹,

Păcală²,

Ştef³

et al. 2018

Rev. Chim.

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Living organisms take nutrients from the environment, and together with them, substances with toxic potential � such as heavy metals. Lead is one common metal pollutant especially in aquatic environment, from where the fish can be intoxicated very easily. Bioavailability, distribution, toxic action, synergistic and antagonistic effects are characteristics which can alter the fish health. Our experimental study followed the effects of lead overload in water on iron distribution, in different tissues sample Carassius gibelio Bloch fish. We performed the experiment in four different fish groups: control C; lead � Pb (administration of lead in water 0.075mg/mL of water, as Pb(NO3)2 x � H2O); lead (the same dose) and 2% of freeze-dry garlic incorporated into fishes� food � Pb+garlic; lead (the same dose) and 2% chlorella incorporated into fishes� food � Pb+chlorella, for 21 consecutive days. The iron concentration was analysed with AAS (Atomic Absorption Spectroscopy) from gills, muscle, skin (and scales), intestine, liver, heart, brain, ovary, testicles, and kidney. The obtained data presented a significantly decrease of iron content in all tested tissue samples that demonstrated, alteration of iron homeostasis, explained by a strong antagonistic effect of lead on iron. Our experiment showed that biologic active principles from garlic and chlorella act like natural protectors, and potentiate the iron deficiency even in the case of lead overload in aquatic environment, for fish.

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Section: Resultsmentioning

confidence: 69%

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

Nicula¹,

Păcală²,

Ştef³

et al. 2018

Rev. Chim.

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“…Toxic metal (arsenic, mercury, cadmium, and lead) exposure during pregnancy is associated with epigenomic changes in the offspring [82,83]. Similarly, epigenomic changes in the offspring have been found associated with the exposure to endocrine disruptors, such as bisphenol-a, dichlorodiphenyltrichloroethane, polybrominated diphenyl ethers, polychlorinated biphenyls, and phthalates [83].…”

Section: First 1000 Days and Epigeneticsmentioning

confidence: 99%

Introductory Chapter: Impact of First 1000 Days Nutrition on Child Development and General Health

Al-Zwaini¹,

Al-Ani²,

Hurley³

2020

Infant Feeding - Breast Versus Formula

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“…This environmental justice problem is potentially intensified by evidence suggesting that lead has epigenetic effects as well. Recent data from animal and human studies suggest that long-term adverse neurologic effects in aging adults exposed to lead as children may be mediated through epigenetic mechanisms [ 55 , 56 ]. At least one study has suggested a multigenerational impact in humans, in which a mother’s blood lead levels affect methylation patterns in the grandchildren [ 57 ].…”

Section: Transgenerational Effectsmentioning

confidence: 99%

Transgenerational epigenetics and environmental justice

Rothstein

Harrell

Marchant

2017

Environmental Epigenetics

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Human transmission to offspring and future generations of acquired epigenetic modifications has not been definitively established, although there are several environmental exposures with suggestive evidence. This article uses three examples of hazardous substances with greater exposures in vulnerable populations: pesticides, lead, and diesel exhaust. It then considers whether, if there were scientific evidence of transgenerational epigenetic inheritance, there would be greater attention given to concerns about environmental justice in environmental laws, regulations, and policies at all levels of government. To provide a broader perspective on environmental justice the article discusses two of the most commonly cited approaches to environmental justice. John Rawls's theory of justice as fairness, a form of egalitarianism, is frequently invoked for the principle that differential treatment of individuals is justified only if actions are designed to benefit those with the greatest need. Another theory, the capabilities approach of Amartya Sen and Martha Nussbaum, focuses on whether essential capabilities of society, such as life and health, are made available to all individuals. In applying principles of environmental justice the article considers whether there is a heightened societal obligation to protect the most vulnerable individuals from hazardous exposures that could adversely affect their offspring through epigenetic mechanisms. It concludes that unless there were compelling evidence of transgenerational epigenetic harms, it is unlikely that there would be a significant impetus to adopt new policies to prevent epigenetic harms by invoking principles of environmental justice.

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Consequences of lead exposure, and it’s emerging role as an epigenetic modifier in the aging brain

Cited by 91 publications

References 117 publications

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

Introductory Chapter: Impact of First 1000 Days Nutrition on Child Development and General Health

Transgenerational epigenetics and environmental justice

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