In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

Nicula, Mărioara; Păcală, N.; Ştef, Lavinia; Peţ, Ioan; Dronca, Dorel; Gherbon, Adriana; Ahmadi, Mirela

doi:10.37358/rc.17.12.5969

Cited by 9 publications

(9 citation statements)

References 9 publications

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“…Likewise, whey contains minerals and lactic acid which is a good source of calcium lactate crystals -chemicals that are responsible for the concentrated acid whey thickening [26]. Other minerals are very important for concentrated whey proteins or isolates, but some potential toxic minerals or essential minerals in excess could decrease the whey quality or could even make it improper as an ingredient of feed or food [27][28][29][30][31].…”

Section: Resultsmentioning

confidence: 99%

Reverse Osmosis of Whey - Valuable Biocomponent of Feed and Food

Ahmadi¹,

Peţ²,

Ştef³

et al. 2020

Rev.Chim.

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Whey is a high-quality dairy by-product from cheese industry, being an important source of valuable proteins. It is important in human and animal nutrition due to its content in enzymes, hormones, vitamins, minerals, and antioxidant compounds, it has low lactose content, very little or it is free of lipids, but the dehydration (drying) technique must be very well chosen to preserve the quantity and quality of components. The objective of our study was to analyze the possibility of concentrating whey by reverse osmosis and having in view the possibility to preserve most of the biochemical properties of whey. Thus, we made comparative tests for quantitative determination of total protein, lipids, pH and acidity for - raw, skimmed and concentrated whey. The results showed that reverse osmosis is a good, cheap and easy-to-use method in cheese factories to obtain whey with well-preserved components. Most of the farmers from western Romania (especially in Timis county) use whey as ingredient of feed products. Studies from previous years present whey as an ingredient of nutritional supplements for animal feeding plan, as well as an ingredient in supplements for athletes and alternative medicine. There are many technological options for whey processing, but the final option must be very well correlated with the final nutritional purpose. Keywords: whey, feed, human, nutrition

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Section: Resultsmentioning

confidence: 99%

Reverse Osmosis of Whey - Valuable Biocomponent of Feed and Food

Ahmadi¹,

Peţ²,

Ştef³

et al. 2020

Rev.Chim.

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“…Some of the heavy metals are essential for living organisms, but in large quantities, they are accumulated in tissues and cells, being able to change the oxidative status leading to oxidative stress allowing the formation of toxic products for the cell. These products could inactivate some enzymes, could damage the proteins and nucleic acids or could allow lipid peroxidation with the formation of free radicals which are very reactive and toxic [24][25][26][27][28][29].…”

Section: Resultsmentioning

confidence: 99%

Influence of Iron Administration on Kidney Serum Parameters

Dronca¹,

Peţ²,

Ştef³

et al. 2020

Rev.Chim.

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Some minerals are essential nutrients for organisms being necessary in different quantities, but any homeostasis disturbance (deficiency or excess) can lead to various diseases. Iron in the body plays a critical role being directly involved in the respiration process - more precisely O2 and CO2 transportation, and also in beneficial oxidation-reduction processes. But sometimes the iron can also lead to the formation of substances with toxicogenic potential, more precisely to free radicals formed as a result of oxidative stress. In the liver, there is a specialized protein - hepcidin - which is the key regulator of circulating iron in the organism. In several cases of overdose, this protein blocks the iron transportation, binds it to the export channels of ferroportin and finally sends the excess iron to the kidney for urinal excretion. Our experiment tried to evaluate if in case of iron intraperitoneal administration in excess to rabbits, for a short period of time, it influences the serum creatinine, uric acid, and blood urea nitrogen if the rabbits were fed with a special organic diet. The results of the experiment presented a lower concentration of creatinine (with 24.46%), uric acid (with more than 41.48%), and blood urea nitrogen - BUN (6.45%) for experimental rabbits compared to the control group, proving that a well-documented diet influences the accumulation and excretion of excess iron. Keywords: iron, creatinine, uric acid, blood urea nitrogen

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“…But, essential trace elements deficiency such as manganese, zinc, copper, chromium, calcium and magnesium enhance lead absorbtion. Consequently, as we have shown in previous works [29][30][31], lead can interfere with tissue calcium, zinc, copper and iron. This may be due to disruption of ceruloplasmin and ferritin production, very important copper and iron-binding proteins.…”

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confidence: 75%

Garlic and Chlorella Biomodulate Lead Toxicity on Manganese Homeostasis in Carassius gibelio Bloch

Nicula¹,

Păcală²,

Ştef³

et al. 2018

Rev. Chim.

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Environmental pollution negatively affects the aquatic ecosystems. Heavy metals are considered dangerous toxic elements for aquatic biota, as metallic elements or as salts which exhibit great stability. Among these, lead is toxic for all aquatic biotic components. Our research investigated the manganese distribution in tissue of Prussian carp fishes after lead intoxication, highlighted also the lead detoxifying potential of active principles from garlic and chlorella (powder). For our experiment 120 Prussian carp fingerlings, weighing 22-25g each, for 21 consecutive days, were divided according to the following treatments: C group (without treatment), E1 group (75ppm Pb in water as Pb(NO3)2 x �H2O), E2 group (75ppm Pb in water+2% freeze-dry garlic in feed), E3 group (75ppm Pb in water+2% freeze-dry chlorella in feed). At the end of the experimental period, tissue samples (gills, muscle myotomers�epaxial, heart, skin and scales, intestine, liver, brain, gonads, kidney) were collected after euthanasia with clove oil. Manganese concentration was analytical performed using AAS (atomic absorption spectrometry). Using fish as bioindicators of lead experimental contamination allowed us to obtain valuable informations about its ability to substitut/remove bioactiv minerals from animal tisssues. In the same time, we could emphasize the efficiency of natural antioxidants or chelators of edible plants (such as garlic) or algae (such as chlorella), to alleviat the lead impact on homeostasis of trace elements from tissues.

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In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

Cited by 9 publications

References 9 publications

Reverse Osmosis of Whey - Valuable Biocomponent of Feed and Food

Reverse Osmosis of Whey - Valuable Biocomponent of Feed and Food

Influence of Iron Administration on Kidney Serum Parameters

Garlic and Chlorella Biomodulate Lead Toxicity on Manganese Homeostasis in Carassius gibelio Bloch

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