Consequences of metal exposure on retinoid metabolism in vertebrates: A review

Defo, Michel Amery; Spear, Philip A.; Couture, Patrice

doi:10.1016/j.toxlet.2013.11.024

Cited by 30 publications

(17 citation statements)

References 85 publications

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“…Defo, INRS-ETE, unpublished data). The discrepancy between these studies could be due to multiple factors such as the exposure time (4 weeks here versus chronic exposure); the nature of fish sampled (captivity against free-ranging fish) and the interactions of multiple stressors found in the natural environment (for example diet quality and availability) or individual biometric parameters such as fish sex, size and age, that probably affected retinoid metabolism (Defo et al, 2014b). We also observed that a down-regulation of this gene was coupled with a decrease in the percentage of liver free dROH.…”

Section: Effect Of Metal Contamination On Liver Retinoid Metabolismmentioning

confidence: 99%

“…ROS production can lead to cellular oxidative stress, itself inducing lipid peroxidation, DNA and protein damage and other adverse effects (Chen et al, 2013;Leonard et al, 2004). Metals have different modes of generating or increasing cellular ROS (Defo et al, 2014b;Lushchak, 2011). In order to counterbalance oxidative damage, gene transcription levels of cellular antioxidant response and the activities of enzymes involved in these metabolic pathways increase in response to higher cellular ROS (Uren Webster et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Transcriptional and biochemical markers in transplanted Perca flavescens to characterize cadmium- and copper-induced oxidative stress in the field

et al. 2015

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Section: Effect Of Metal Contamination On Liver Retinoid Metabolismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcriptional and biochemical markers in transplanted Perca flavescens to characterize cadmium- and copper-induced oxidative stress in the field

et al. 2015

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“…Most studies involving antioxidants and their role in combating cellular oxidative stress in animals have focused on the alteration in various endogenous enzymatic and non-enzymatic components of the antioxidant defence system (such as SOD, CAT, GPx, GSH). In contrast, only a few studies have examined exogenous antioxidants such as retinoids and vitamin E (Rodriguez-Estival et al 2011, Defo et al 2014.…”

Section: Discussionmentioning

confidence: 99%

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

Spodniewska¹,

Barski²

2016

Polish Journal of Veterinary Sciences

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The aim of the study was to determine the level of antioxidant vitamins A and E in the liver of rats exposed to chlorpyrifos and/or enrofloxacin. Chlorpyrifos (Group I) was administered at a dose of 0.04 LD 50 (6 mg/kg b.w.) for 28 days, and enrofloxacin (Group II) at a dose of 5 mg/kg b.w. for 5 consecutive days. The animals of group III were given both of the mentioned above compounds at the same manner as groups I and II, but enrofloxacin was applied to rats for the last 5 days of chlorpyrifos exposure (i.e. on day 24, 25, 26, 27 and 28). Chlorpyrifos and enrofloxacin were administered to rats intragastrically via a gastric tube. The quantitative determination of vitamins was made by the HPLC method. The results of this study indicated a reduction in the hepatic concentrations of vitamins A and E, compared to the control, which sustained for the entire period of the experiment. The four-week administration of chlorpyrifos to rats resulted in a significant decrease of vitamins in the initial period of the experiment, i.e. up to 24 hours after exposure. For vitamin A the maximum drop was observed after 24 hours (19.24%) and for vitamin E after 6 hours (23.19%). Enrofloxacin caused a slight (3-9%) reduction in the level of the analysed vitamins. In the chlorpyrifos-enrofloxacin co-exposure group reduced vitamins A and E levels were also noted, but changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only. The decrease in the antioxidant vitamin levels, particularly noticeable in the chlorpyrifos-and the chlorpyrifos combined with enrofloxacin-treated groups, may result not only from the increase in the concentration of free radicals, but also from the intensification of the secondary stages of lipid peroxidation.

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“…Surface water contaminants such as pesticides (e.g., atrazine, metolachlor) have been reported to modify the retinoic signalling pathway (Bérubé et al 2005;Novák et al 2008) and to induce organism malformations (e.g., skeletal deformities) in fish larvae (Inoue et al 2010;Yutaka et al 2011). Metals have been found to alter retinoidmetabolizing enzymes (Defo et al 2014), changes in gene transcription (Pierron et al 2011) or dysfunction of hepatic storage capacity (Defo et al 2012) in fish. Polychlorinated biphenyl (PCB) 77 has also been reported to increase in vivo the metabolization of retinoic acid in rainbow trout (Gilbert et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Integrated spatial health assessment of yellow perch (Perca flavescens) populations from the St. Lawrence River (QC, Canada), part B: cellular and transcriptomic effects

Bruneau

Landry

Giraudo

et al. 2016

Environ Sci Pollut Res

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Multi-biological level assessments have become great tools to evaluate the health of aquatic ecosystems. Using this approach, a complementary study was designed to evaluate the health of yellow perch (Perca flavescens) populations in the St. Lawrence River (Quebec, Canada). In the present study, stress responses were compared at the transcriptomic, cellular, and tissue levels in yellow perch collected at six sites along the river: Lake St. François, Lake St. Louis (north and south), Beauregard Island and Lake St. Pierre (north and south). These results complement the physiological and chemical parameters as well as pathogen infection investigated in a companion paper published in the present issue. Thiobarbituric acid reactive substance (TBARS) analyses indicated the presence of oxidative stress in fish collected in the southern part of Lake St. Louis and at the downstream sites of Lake St. Pierre. High lipid peroxidation levels were found in the muscle of yellow perch caught at Beauregard Island, located downstream of the Montreal's wastewater treatment plant, suggesting an impact of the municipal effluent on redox homeostasis. Transcriptomic results indicated the down-regulation of genes related to lipid, glucose, and retinoid in southern Lake St. Pierre as well as a decrease in retinoid storage. Overall, biochemical and molecular markers indicated that the health status of yellow perch followed a decreasing gradient from upstream to downstream of the St. Lawrence River. This gradient is representative of the cumulative negative impacts of human activities on water and habitat quality along the river.

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Consequences of metal exposure on retinoid metabolism in vertebrates: A review

Cited by 30 publications

References 85 publications

Transcriptional and biochemical markers in transplanted Perca flavescens to characterize cadmium- and copper-induced oxidative stress in the field

Transcriptional and biochemical markers in transplanted Perca flavescens to characterize cadmium- and copper-induced oxidative stress in the field

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

Integrated spatial health assessment of yellow perch (Perca flavescens) populations from the St. Lawrence River (QC, Canada), part B: cellular and transcriptomic effects

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