2002
DOI: 10.1523/jneurosci.22-07-02894.2002
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Conservation of Spatial Memory Function in the Pallial Forebrain of Reptiles and Ray-Finned Fishes

Abstract: The hippocampus of mammals and birds is critical for spatial memory. Neuroanatomical evidence indicates that the medial cortex (MC) of reptiles and the lateral pallium (LP) of ray-finned fishes could be homologous to the hippocampus of mammals and birds. In this work, we studied the effects of lesions to the MC of turtles and to the LP of goldfish in spatial memory. Lesioned animals were trained in place, and cue maze tasks and crucial probe and transfer tests were performed. In experiment 1, MC-lesioned turtl… Show more

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Cited by 285 publications
(237 citation statements)
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“…It will therefore be interesting to determine whether the activity-dependent association of AptNR2B and CaMKII is part of the molecular basis of adaptive sensory filtering in ELL (Bastian 1999). Recent studies have demonstrated that the dorsolateral forebrain of teleost fish is essential for spatial memory (Rodriguez et al 2002) and have suggested that this region is similar to mammalian hippocampus. In Apteronotus, this brain region has very high levels of NR1 (Bottai et al 1997), AptNR2B (R. Dunn and L. Maler, unpublished observations), and CaMKII (Bottai et al 1997).…”
Section: Evolutionary Conservation Of Regulatory Sites On the Cterminmentioning
confidence: 99%
“…It will therefore be interesting to determine whether the activity-dependent association of AptNR2B and CaMKII is part of the molecular basis of adaptive sensory filtering in ELL (Bastian 1999). Recent studies have demonstrated that the dorsolateral forebrain of teleost fish is essential for spatial memory (Rodriguez et al 2002) and have suggested that this region is similar to mammalian hippocampus. In Apteronotus, this brain region has very high levels of NR1 (Bottai et al 1997), AptNR2B (R. Dunn and L. Maler, unpublished observations), and CaMKII (Bottai et al 1997).…”
Section: Evolutionary Conservation Of Regulatory Sites On the Cterminmentioning
confidence: 99%
“…In all species studied, including teleost fish, amphibians, reptiles, and mammals, relational representations are mediated by structures in the brain that embryologically derive from the most medial part of the telencephalic anlage (Rodriguez et al 2002). In mammalian species, this derivative is called the hippocampal formation, and it is of interest that a correlation apparently exists between the volume of the hippocampal formation and successful spatial performance.…”
Section: Introduction: a Comparative Perspectivementioning
confidence: 99%
“…In addition, MC lesioned turtles trained in a standard four-arm maze place task suffer a place-learning impairment as revealed by their failure to reach the goal during test trials. In fact, these animals lose the ability to navigate to the goal when they start from novel positions, and when the visual cues in its proximity are excluded [37]. These results indicate that MC lesioned turtles lack the capacity to encode goal location relative to the environmental features in a relational, map-like representation (place learning).…”
Section: Medial Pallium or Hippocampus And Map-like Memories In Amniotesmentioning
confidence: 92%