Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

Vasconcelos, Inês; Mendes, Miguel de Sousa

doi:10.1016/j.ejca.2015.01.004

Cited by 113 publications

(105 citation statements)

References 58 publications

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“…However, the literature also contains reports on the possibility of bilateral cystectomy in the case of bilateral ovarian involvement and explicit fertility-preserving desire. Vasconcelos et al concluded that in this situation, there are no indications of increased recurrence rates compared to unilateral adnexectomy with contralateral cystectomy [12]. It should also be noted that the surgical procedure in this case complied with guidelines.…”

mentioning

confidence: 61%

“…However, at the 70-month follow-up, the higher recurrence rate was not associated with a higher mortality. The rate of progression into invasive ovarian cancer has been reported at 2 % [12,16]. However, it must be critically noted that in up to 30 % of all cases, the recurrence of a borderline tumour represents a classic invasive epithelial ovar- ian cancer with a much worse prognosis [17].…”

mentioning

confidence: 99%

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Twenty-five-year-old Woman with Bilateral Borderline Ovarian Tumour Desiring to Preserve Fertility – Case Report and Literature Review on the Current State of Fertility Preservation in Women with Borderline Ovarian Tumours

Findeklee

Lotz

Hoffmann

et al. 2016

Geburtshilfe Frauenheilkd

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Borderline ovarian tumours are semimalignant tumours occurring unilaterally or bilaterally with a peak incidence among women of reproductive age. Since the affected women often wish to preserve fertility, particular precautions must be taken when counselling the patient and obtaining consent prior to planning an individual treatment. Options for preserving fertility include an organ-sparing surgical procedure and cryopreservation of oocytes and/or ovarian tissue. In this article, we report on a 25-year-old patient with a bilateral seromucinous borderline tumour who desired all fertility-preserving options. In order to perform the procedure without delay, we opted to perform luteal phase stimulation prior to oocyte retrieval. We conclude by discussing the current literature on the state of fertility preservation in the treatment of borderline ovarian tumours.

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mentioning

confidence: 61%

mentioning

confidence: 99%

Twenty-five-year-old Woman with Bilateral Borderline Ovarian Tumour Desiring to Preserve Fertility – Case Report and Literature Review on the Current State of Fertility Preservation in Women with Borderline Ovarian Tumours

Findeklee

Lotz

Hoffmann

et al. 2016

Geburtshilfe Frauenheilkd

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“…Several recommendations have been made to perform an USO as fertility sparing approach, while a cystectomy is still considered adequate by others [3,5,25] . A recent large meta-analysis of 5,105 women with BOT confirmed that USO is advisable in MBOT [21] . Several studies found a significant decrease of progression-free survival when cystectomy was performed instead of USO [2,13,26] .…”

Section: Discussionmentioning

confidence: 97%

“…However, we are convinced that the separate categories of BOT represent completely different entities with specific pathological and clinical characteristics, underlining the importance of correct and expert pathology in these cases [12] . Even within the subgroup of MBOT, a further classification dividing into intestinal-and endocervical-subtypes is important [6,8,15,16,20,21] . The latter are more related to serous BOT than the intestinaltype MBOTs [22,23] .…”

Section: Discussionmentioning

confidence: 99%

Staging with Unilateral Salpingo-Oophorectomy and Expert Pathological Review Result in No Recurrences in a Series of 81 Intestinal-Type Mucinous Borderline Ovarian Tumors

Dewilde

Moerman

Leunen

et al. 2017

Gynecol Obstet Invest

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Objective: Recent studies suggest that mucinous borderline ovarian tumors (MBOTs) belong to a high-risk group that is more likely to develop an invasive recurrence. The objective is to determine these risk factors. Methods: A monocentric retrospective review of all consecutive patients with intestinal-type MBOT diagnosed between 1993 and 2013. All tumors were evaluated by one pathologist without knowledge of clinical outcome. Extensive surgical staging and pathological tumor sampling (1 block/cm diameter in tumors <10 cm and 2 blocks/cm diameter in tumors >10 cm) were performed in all cases. Results: A total of 81 patients were included. Patients with micro-invasion were also included. None of the patients recurred. No bilateral tumors, nor tumors with International Federation of Gynecology and Obstetrics stage II or higher, were diagnosed. Median follow-up was 87 months. Conclusions: In our series of pure intestinal-type MBOT, including micro-invasion, no recurrences were observed. Given the heterogeneity of these tumors staging with at least unilateral salpingo-oophorectomy, extensive pathological sampling, and expert pathological review are of paramount importance to be able to diagnose a pure intestinal-type MBOT and excluding gastrointestinal mucinous tumors and more important, excluding an invasive focus, defining a mucinous ovarian carcinoma. When these conditions are fulfilled, the prognosis of pure intestinal-type MBOT is excellent.

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“…Apart patients with FIGO stage IA G1-2 for whom fertility sparing treatment is largely accepted; only few data for higher stages or aggressive histologies are available. Anyway comparable oncologic and obstetrical results seem achievable [12][13][14][15][16][17].…”

Section: Ovarian Cancermentioning

confidence: 87%

Fertility Sparing Options in Gynecologic Oncology

Martinelli¹,

Ditto²,

Bogani³

et al. 2016

Gynecol Obstet

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Conservative surgery in ovarian borderline tumours: A meta-analysis with emphasis on recurrence risk

Cited by 113 publications

References 58 publications

Twenty-five-year-old Woman with Bilateral Borderline Ovarian Tumour Desiring to Preserve Fertility – Case Report and Literature Review on the Current State of Fertility Preservation in Women with Borderline Ovarian Tumours

Twenty-five-year-old Woman with Bilateral Borderline Ovarian Tumour Desiring to Preserve Fertility – Case Report and Literature Review on the Current State of Fertility Preservation in Women with Borderline Ovarian Tumours

Staging with Unilateral Salpingo-Oophorectomy and Expert Pathological Review Result in No Recurrences in a Series of 81 Intestinal-Type Mucinous Borderline Ovarian Tumors

Fertility Sparing Options in Gynecologic Oncology

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