Conservative Therapy for Microinvasive Carcinoma of the Uterine Cervix

Ueki, Minoru; Okamoto, Yoshiaki; Misaki, O.; Seiki, Y.; Kitsuki, K.; Ueda, Masatsugu; Sugimoto, Osamu

doi:10.1006/gyno.1994.1096

Cited by 34 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is generally agreed that patients with stage IA1 cervical squamous cell carcinoma can be treated adequately using nonradical treatments such as simple hysterectomy or conization [12], and reports on the efficacy of conservative management such as conization in these patients are increasing [13][14][15]. However, concerns remain about residual disease and risk of persistence or recurrence when treating these patients with conization alone.…”

Section: Discussionmentioning

confidence: 99%

Conservative management of stage IA1 squamous cell carcinoma of the cervix with positive resection margins after conization

Kim

Chang

et al. 2010

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective: To evaluate the efficacy of cold knife conization with electrocauterization and the feasibility of conservative management in patients with stage IA1 carcinoma of the cervix according to margin status after conization. Methods: Medical and histopathological records of 108 patients with stage IA1 cervical carcinoma were reviewed retrospectively. Patients underwent cold knife conization with electrocauterization or conization followed by hysterectomy. Disease recurrence was defined as a histologic diagnosis of cervical intraepithelial neoplasia (CIN) 2 or higher grade lesion. Results: Forty patients underwent conization followed by hysterectomy; of 27 women with positive margins, 14 (35%) had a residual lesion. Sixty-eight patients underwent conization without further surgical intervention. Forty patients had a negative resection margin without recurrence, while 28 had a positive resection margin: positive exocervical (n = 11), positive endocervical (n = 17). Among these, there were 7 cases of recurrence: positive exocervical (n = 1); positive endocervical (n = 6). Conclusion: Cold knife conization with electrocauterization appears to be a safe treatment option for patients with stage IA1 cervical carcinoma if careful follow-up is guaranteed for patients with CIN 3 exocervical resection margins. However, patients with CIN 3 endocervical resection margins should be managed surgically with repeat conization or hysterectomy. Crown

show abstract

Section: Discussionmentioning

confidence: 99%

Conservative management of stage IA1 squamous cell carcinoma of the cervix with positive resection margins after conization

Kim

Chang

et al. 2010

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…7,14Y16 In addition, cervical cancer patients with an invasion depth no greater than 3 mm and negative conization resection margins have a minimal chance of lymph node metastasis and a nearly 100% cure rate when treated with nonradical methods such as simple hysterectomy or conization alone. 17 Although conservative treatments such as conization have been found to be sufficient for stage IA 1 disease, 4,14,18,19 the margin status of cone biopsies have become important in determining treatment adequacy. Roman et al 9 reported 87 cases of microinvasive carcinoma diagnosed by cone biopsy and followed by either repeated cone biopsy or hysterectomy.…”

Section: Discussionmentioning

confidence: 99%

Conization Using Electrosurgical Conization and Cold Coagulation for International Federation of Gynecology and Obstetrics Stage IA1 Squamous Cell Carcinomas of the Uterine Cervix

Lee

Kim²,

Lee³

et al. 2009

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

These results suggest that electrosurgical conization with cold coagulation is a feasible treatment and could be used as a definitive therapy for patients with stage IA1 cervical squamous cell carcinoma without lymphovascular space invasion. In addition, patients having cervical intraepithelial neoplasias 2 and 3 at exocervical resection margins could be followed up carefully without further treatment after conization and cold coagulation.

show abstract

“…Therefore, treatment can consist of simple hysterectomy. Furthermore, in young women with stage IA1 cervical cancer who desire fertility preservation, conization alone may be used for definite treatment [10,11]. …”

Section: Introductionmentioning

confidence: 99%

Is Radical Hysterectomy Necessary in Early Cervical Cancer?

Meirovitz

Sade²,

Dreiher³

et al. 2013

Gynecol Obstet Invest

View full text Add to dashboard Cite

Aims: To estimate the prevalence of tumor spread to the parametrium, vagina and uterine corpus in radical hysterectomy specimens and define a subgroup of patients with low-risk of extracervical involvement, who may benefit from less radical surgery. Methods: We retrospectively reviewed 96 patients with stage IA1-IIA cervical cancer who had undergone radical hysterectomy and pelvic lymphadenectomy. Results: Tumor spread beyond the uterine cervix was evident in 45 (47%) patients. Thirteen (13%) of the 96 patients had parametrial tumor spread, 12 (13%) had vaginal tumor extension, and 23 (24%) had uterine corpus involvement. Tumor size >2 cm, stromal invasion to a depth of ≥8 mm, and lymph vascular space invasion (LVSI) were significantly associated with extracervical invasion. Twenty-five patients had stromal invasion of <8 mm and no LVSI, of which only 1 (4%) had extracervical involvement. On the contrary, extracervical involvement was evident in 44 patients (63%) among those who had stromal invasion of ≥8 mm and/or LVSI (p < 0.001). Among women with LVSI, extracervical tumor spread was seen with any tumor size and any depth of stromal invasion. All patients with stromal invasion to a depth of >15 mm had extracervical invasion. Conclusion: Patients with tumor size <2 cm, depth of invasion of <8 mm and no LVSI could be considered for less radical surgery.

show abstract

Conservative Therapy for Microinvasive Carcinoma of the Uterine Cervix

Cited by 34 publications

References 0 publications

Conservative management of stage IA1 squamous cell carcinoma of the cervix with positive resection margins after conization

Conservative management of stage IA1 squamous cell carcinoma of the cervix with positive resection margins after conization

Conization Using Electrosurgical Conization and Cold Coagulation for International Federation of Gynecology and Obstetrics Stage IA1 Squamous Cell Carcinomas of the Uterine Cervix

Is Radical Hysterectomy Necessary in Early Cervical Cancer?

Contact Info

Product

Resources

About