Conservative treatment of big yolk sac tumour of the ovary in young girl

Beurdeley, M.; Gauthier, Tristan; Piguet, Christophe; Fourcade, Laurent

doi:10.1016/j.jviscsurg.2010.08.007

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Yolk sac tumors of the ovary are difficult to diagnose. Thus, multiple examinations of pathological slides are needed to ensure that these are not mixed tumors, especially tumors containing teratomas [6]. In the clinical setting, the presence of these globules, along with the production of AFP, can be diagnosed as yolk sac tumors of the ovary.…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathological features of hepatoid carcinoma of the ovary

et al. 2013

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Hepatoid carcinoma of the ovary (HCO), a rare invasive malignant tumor composed mainly of epithelioid cells, presented with unilateral or bilateral ovarian masses and elevated serum α-fetoprotein (AFP), has been found mainly in post-menopausal women. We hereby report on the case of a 53-year-old Chinese woman who presented with abdominal distension and a lower abdominal mass with high serum levels of CA-125 and AFP. She was later diagnosed with bilateral HCO. After surgery and following chemotherapy, the patient had no recurrence of tumor or ascites. The hepatoid cells were positive for AFP, p53 and CK7 by immunohistochemistry. Her serum CA-125 and AFP levels had decreased significantly after surgery. Our results suggest that testing and monitoring of serum levels of AFP and CA-125 are considered as potential biomarkers in the diagnosis and progression of this malignancy, and that tissue immunohistochemical staining for AFP, p53 and CK7, plays an important role in distinguishing HCO from other ovarian tumors.

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Section: Discussionmentioning

confidence: 99%

Clinical and pathological features of hepatoid carcinoma of the ovary

et al. 2013

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“…Unlike clear cell carcinoma, yolk sac tumor is very chemosensitive and in some cases, an evaluation of the postoperative chemotherapy response may be useful for diagnosis [2] For young patients wishing to preserve their fertility like in our case, surgical treatment consists in unilateral adnexectomy via laparotomy with peritoneal washing and complete staging procedure including peritoneal cytology as well as peritoneal and omental biopsies. Chemotherapy combines several molecules and represents a promising strategy to reduce the risk of recurrence [1]- [6]. In our case, the patient has benefited from a BEP-type protocol (bleomycin, etoposide, cisplatin).…”

Section: Discussionmentioning

confidence: 84%

“…Intraperitoneal rupture generally occurs in 30% of cases and can be pre-or intraoperative. In addition, associated peritonitis can also be observed, secondary to ascitic [1]- [6]. Macroscopically, the ovarian mass is encapsulated and ranged in size from 3 to 30 cm.…”

Section: Discussionmentioning

confidence: 99%

Refractory Ascites Revealing an Ovarian Yolk Sac Tumor with Intraperitoneal Rupture

Razafimahefa¹,

Razafindrafara²,

Rafaralahivoavy³

et al. 2023

OJPathology

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Yolk sac tumors of the ovary are rare entities that account for 2% -5% of all ovarian tumors. They represent the second most common histological variant of malignant germ cell tumors of the ovary after dysgerminomas. Yolk sac tumors are most commonly encountered in women in the second and third decades. Microscopically, they are highly polymorphic and can present in a pure form or associated with another contingent of germ cell tumor. We report the case of a 26-year-old woman, who underwent surgery for a large right ovarian tumor rupturing into the peritoneal cavity. The ovarian tumor was revealed by ascites of great abundance and abdomino-pelvic pain. On histological examination, the diagnosis of yolk sac tumor in its pure and polyvesicular vitelline pattern was made. Through this observation, we propose to discuss the anatomoclinical particularities of these tumors by emphasizing the importance of histology for the diagnosis as well as the need of an early and appropriate management.

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“…In the clinical setting, the presence of the globules, along with the production of AFP, can be diagnosed as yolk sac tumors of the ovary. 6 Endometrial adenocarcinomas rarely produce AFP. Microscopically, endometrial tumors are usually composed of a major medullary portion and a minor tubular adenocarcinoma invading the myometrium.…”

Section: Discussionmentioning

confidence: 99%