Consideration of Preventing Local Venous Pain by Dacarbazine

Ohtsubo, Tatsuya; Tsuji, Takao; Umeyama, Takayo; Sudou, Miho; Komesu, Kana; Matsumoto, Minako; Yoshida, Yuya; Banno, Rie; Tomogane, Kanji; Fujita, Atsuo; Kohno, Takeyuki; Mikami, Tadashi

doi:10.1248/yakushi.16-00222

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Recent reports have demonstrated that light shielding during the infusion process reduced the photo-degradation of DTIC. 3,6,9) The infusion process of DTIC requires 2-3 h, while the dissolving and diluting processes require a total of 10 min. A short duration of light exposure most likely does not increase the production of Diazo-IC.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported the procedure for reducing the pain reaction during peripheral intravenous infusion of DTIC. [4][5][6][7] The dissolving solution selected and the adjustment of its pH were found to affect the photo-degradation. 8) Light shielding infusion bags with a light-blocking sheet reduced the generation of Diazo-IC during peripheral intravenous infusion.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Light Shielding on Photo-Degradation of Dacarbazine during the Preparation Process

Tashiro

Naito

Yamamoto

et al. 2019

Biological & Pharmaceutical Bulletin

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Dacarbazine (DTIC) is converted to the photo-degradation product 4-diazoimidazole-5-carboxamide (Diazo-IC) by light. Diazo-IC production is often responsible for the pain reactions observed during peripheral intravenous infusion of DTIC in clinical settings. Although light shielding during infusion decreases the photo-degradation of DTIC, its usefulness for the preparation of DTIC has not yet been fully clarified. The aim of this study was to investigate the light conditions during the preparation of DTIC solution in the compounding room from the viewpoint of the production amount of Diazo-IC. DTIC solution was prepared in the compounding room. Various light and temperature conditions and dissolving solutions during the preparation were investigated. The amounts of DTIC and Diazo-IC in solutions were determined using an HPLC coupled to UV detection. The photo-degradation of DTIC was estimated by the amount of Diazo-IC. Diazo-IC production in the dissolving solutions increased in a time-dependent manner at 4 and 25°C under light shielding. Light exposure during the dissolving process did not affect the DTIC and Diazo-IC concentrations. Light shielding during dissolution did not alter the Diazo-IC production until 4 h after dilution. In conclusion, short duration light exposure did not affect Diazo-IC production. These findings suggest that light shielding is not needed in the preparation of DTIC in the compounding room from the viewpoint of Diazo-IC production.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Light Shielding on Photo-Degradation of Dacarbazine during the Preparation Process

Tashiro

Naito

Yamamoto

et al. 2019

Biological & Pharmaceutical Bulletin

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“…However, the poor solubility and short half-life of DTIC in water further limit its application in combination therapy. Therefore, a promising strategy to overcome these limitations is to encapsulate DTIC in nanocarriers for targeted delivery to tumor cells . Many approaches have been developed for the treatment of malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, a promising strategy to overcome these limitations is to encapsulate DTIC in nanocarriers for targeted delivery to tumor cells. 9 Many approaches have been developed for the treatment of malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment

Liu

Zhao

et al. 2023

Biomacromolecules

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Melanoma is resistant to conventional chemotherapy and radiotherapy. Therefore, it is essential to develop a targeted, low-toxic, and minimally invasive treatment. Here, DTIC/ICG-Fe3O4@TpBD BSP/HA microneedles (MNs) were designed and fabricated, which can enhance targeting to melanoma and perform photothermal therapy (PTT) and chemotherapy simultaneously to synergistically exert anticancer effects. The system consisted of magnetic nanoparticles (DTIC/ICG-Fe3O4@TpBD), dissoluble matrix (Bletilla polysaccharide (BSP)/hyaluronic acid (HA)), and a polyvinyl alcohol backing layer. Due to the good magnetic responsiveness of Fe3O4@TpBD, dacarbazine (DTIC) and indocyanine green (ICG) can be better targeted to the tumor tissue and improve the therapeutic effect. BSP and HA have good biocompatibility and transdermal ability, so that the MNs can completely penetrate the tumor tissue, be dissolved by the interstitial fluid, and release DTIC and ICG. Under near-infrared (NIR) light irradiation, ICG converts light energy into thermal energy and induces ablation of B16-OVA melanoma cells. In vivo results showed that DTIC/ICG-Fe3O4@TpBD BSP/HA MNs combined with chemotherapy and PTT could effectively inhibit the growth of melanoma without tumor recurrence or significant weight loss in mice. Therefore, DTIC/ICG-Fe3O4@TpBD BSP/HA MNs are expected to provide new ideas and therapeutic approaches for the clinical treatment of melanoma.

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“…Moreover, usage of DC in the treatment of melanoma is restricted due to its various disadvantages. First problem with DC is it is administered in blood by intravenous route only which is a painful route of administration and usually patient avoids this due to incompliance 18 . Second is the absorption rate of DZ is in general incomplete, slow and erratic because of its poor water solubility 19 .…”

Section: Introductionmentioning

confidence: 99%

Dacarbazine nanoparticle topical delivery system for the treatment of melanoma

Hafeez

Kazmi

2017

Sci Rep

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Dacarbazine (DZ) is poorly soluble in water with the short half-life in blood circulation, low rate of response with the toxic effect which ultimately limits its utilization of the treatment of skin cancer. In view of this background current study was designed for development of dacarbazine laden nanoparticle (DZNP) and dacarbazine laden nanocream (DZNC) topical delivery system for the treatment of melanoma. Firstly DZNP was prepared. By using DZNP its cream formulation prepared for topic drug delivery for melanoma. Dacarbazine nanoparticle and its cream were evaluated for morphology, drug load capacity, efficiency of nanoencapsulation and size of particle and zeta potential, Transmission Electron Microscopy (TEM), determination of pH, spreadability and viscosity, in vitro drug release capacity and its cytotoxic potential. The particle size of DZNP and DZNC was 16.3 ± 8.1 nm and 16.9 ± 7.8 nm respectively. pH value and spreadability of nanoparticle cream were found to be 6.7 ± 0.14 g cm/sec and 55.23 ± 3.13 g cm/sec respectively. Nanoencapsulation efficiency and Drug loading capacity were 67.4 ± 3.5% and 6.73 mg/10 mg respectively. IC50 of dacarbazine nanoparticle was 0.19 mg/ml while it was 0.63 mg/ml for nanoparticle cream. It can be concluded that DZNP and its cream can be effectively used as a topical formulation for the treatment of melanoma.

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Consideration of Preventing Local Venous Pain by Dacarbazine

Cited by 6 publications

References 6 publications

Impact of Light Shielding on Photo-Degradation of Dacarbazine during the Preparation Process

Impact of Light Shielding on Photo-Degradation of Dacarbazine during the Preparation Process

Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment

Dacarbazine nanoparticle topical delivery system for the treatment of melanoma

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