Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

Linz, Dominik; Verheule, Sander; Isaacs, Aaron; Schotten, Ulrich

doi:10.15420/aer.2020.51

Cited by 3 publications

(3 citation statements)

References 97 publications

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“…For primary prevention strategy to prevent the development of AF and reduction of AF burden, AI can help to integrate information from multi-dimensional clinical parameters to create biomarkers that can inform on AF risk and risk of AF progression. 183 …”

Section: Artificial Intelligence In the Detection And Management Of A...mentioning

confidence: 99%

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Linz,

Andrade,

Arbelo

et al. 2024

Europace

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Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.

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Section: Artificial Intelligence In the Detection And Management Of A...mentioning

confidence: 99%

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Linz,

Andrade,

Arbelo

et al. 2024

Europace

Self Cite

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“…Genomewide association studies have also identified many common genetic AF suscep-tibility variants throughout the genome. Polygenic risk scores derived from these can be used to successfully predict a person's risk of developing AF [17].…”

Section: Biomarkers and Genetic Architecturementioning

confidence: 99%

New concepts in atrial fibrillation pathophysiology

Hermans

Weberndörfer

Bijvoet

et al. 2022

Herzschr Elektrophys

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The current classification of atrial fibrillation (AF) is mainly focused on the clinical presentation according to the duration of AF episodes and the mode of termination, which incompletely reflect the severity and progressive nature of the underlying atrial disease. In this review article, “atrial cardiomyopathy” is discussed as a new concept in AF pathophysiology. Electrogram-, imaging-, and biomarker-derived measures and parameters to assess atrial cardiomyopathy, which will likely impact how AF is clinically classified and managed in the future, are presented.

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“…Thus, regular physical activity is important for mitigating cardiovascular risks, especially those associated with obesity, metabolic syndrome, dyslipidemia, and hypertension [ 3 , 6 , 16 ]. Despite the demonstrated cardiovascular benefits of PA in several studies [ 3 , 6 , 17 , 18 ], the relationships between intensity, exercise duration, and AF risk remain obscure. Athletes are required to maintain a certain level of effort for as long as possible.…”

Section: Introductionmentioning

confidence: 99%

Atrial Fibrillation in Endurance Training Athletes: Scoping Review

Lobo,

Naves,

Marçal

et al. 2023

Rev. Cardiovasc. Med.

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Background: Moderate regular physical activity is indicated to avoid atrial fibrillation (AF), whereas athletes should be counseled that long-lasting vigorous sports engagement may cause AF, according to the 2016 European Society of Cardiology (ESC) recommendations for AF treatment. Exercise and AF are complex. Objectives: To evaluate the relationship between Endurance training and AF, in addition to the starting point/trigger by which Endurance Training causes impairment of cardiac function and AF, considering the time and intensity of Endurance training. Materials and Methods: We synthesized evidence from articles published in the PubMed, EMBASE, and SciELO databases using their respective Boolean operators. A total of 112 original articles related to AF and endurance athletes published up to the year 2023 were reviewed. Results: Our study verified multiples aspects of the genesis of AF in athletes, such as cardiac adaptations to exercise, disturbances in cardiac injury biomarkers, sex differences in cardiac adaptations and their role in AF risk, and the relationship between body composition (height, weight, and physical fitness) and AF pathogenesis. Conclusions: Variations in cardiac structure (increased atrial thickness and size in addition to myocardial fibrosis) and significant increases in vagal tone (sinus bradycardia and imbalances in sympathetic and parasympathetic activation) shorten the refractory period shortening in athletes, induce the onset of re-entrance mechanisms, and serve as ectopic triggers that can lead to AF.

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Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

Cited by 3 publications

References 97 publications

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

New concepts in atrial fibrillation pathophysiology

Atrial Fibrillation in Endurance Training Athletes: Scoping Review

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