Considerations in Assessing the Clinical Course and Severity of Rotavirus Gastroenteritis

D'Agostino, James

doi:10.1177/000992280604500301

Cited by 5 publications

(11 citation statements)

References 45 publications

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“…Antiviral activity was provided for compounds with one butoxyl group in A ring (38), one ethyl radical in B ring (21) and one benzyloxyl radical simultaneously in A and B rings (39).…”

Section: Discussionmentioning

confidence: 99%

“…The infections may be asymptomatic or may present mild vomiting and/or diarrhea, but can also cause severe disease leading to potentially fatal dehydration. Currently, the goals of treatment of rotaviruses gastroenteritis are to prevent and treat dehydration, and prevent nutritional damage during and after diarrhea episodes [21]. Recently, two rotavirus vaccines have entered in the market: RotaRix (GlaxoSmithKline) and RotaTeq (Merck/CSL) and several issues could be resolved with these new vaccines [22].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…Flavonoids have been investigated for antiviral activity, for instance, against human cytomegalovirus [12,13], herpes simplex virus types 1 and 2 [14][15][16][17], influenza virus, respiratory syncitial virus, adenovirus, varicella zoster virus [12], poliovirus [14,18,19], rhinovirus [19], sindbis virus [20], coronavirus, parainfluenzavirus, coxsackievirus B [8], HIV [21] and rotavirus [6].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of antirotavirus activity of flavonoids

et al. 2010

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Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure-activity relationships (SAR) were proposed based on antirotavirus activity.

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“…Antiviral activity was provided for compounds with one butoxyl group in A ring (38), one ethyl radical in B ring (21) and one benzyloxyl radical simultaneously in A and B rings (39).…”

Section: Discussionmentioning

confidence: 99%

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of antirotavirus activity of flavonoids

et al. 2010

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“…The virus is transmitted by the faecal-oral route and its replication causes damage to cells in the small intestine resulting in diarrhoea with vomiting, and an increased loss of electrolytes in the liquid stool and dehydration (Tallett et al, 1977;Malek et al, 2006). The only known treatment for rotavirus gastroenteritis is the replacement of fluids and electrolytes, since there is no specific drug against the virus (Farthing, 2001;D'Agostino, 2006;Walker et al, 2011). In 1999, a highly efficacious rotavirus vaccine licensed in the United States, RotaShield, was withdrawn from the market after 14 months because of its association with intussusceptions.…”

Section: Introductionmentioning

confidence: 99%

Screening of Brazilian medicinal plants for antiviral activity against rotavirus

Cecílio

Faria

Oliveira

et al. 2012

Journal of Ethnopharmacology

109

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“…The clinical presentation of RV disease ranges from transient, mild diarrhea to severe episodes of acute fever, vomiting and watery diarrhea. At its most serious, RV gastroenteritis (RVGE) results in rapid dehydration, which, in the absence of oral or intravenous rehydration therapy, can result in circulatory collapse and death [2,3].…”

mentioning

confidence: 99%

Human rotavirus vaccine (Rotarix): focus on effectiveness and impact 6 years after first introduction in Africa

O’Ryan¹,

Giaquinto²,

Benninghoff³

2015

Expert Review of Vaccines

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A decade after licensure of the human rotavirus vaccine (HRV), a wealth of evidence supports a reduction of rotavirus (RV) gastroenteritis-associated mortality and hospitalizations following HRV inclusion in national immunization programs. Nevertheless, the majority of real-world data has been generated in high- or middle-income settings. Clinical efficacy trials previously indicated RV vaccine performance may be lower in less-developed countries compared with wealthier counterparts. Using recently published data from Africa, we examine the effectiveness and impact of HRV in resource-deprived areas, exploring whether vaccine performance differs by socioeconomic setting and the potential underlying factors. HRV vaccine effectiveness in early adopting African countries has proven to be similar or even superior to the efficacy results observed in pre-licensure studies.

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Considerations in Assessing the Clinical Course and Severity of Rotavirus Gastroenteritis

Cited by 5 publications

References 45 publications

Evaluation of antirotavirus activity of flavonoids

Evaluation of antirotavirus activity of flavonoids

Screening of Brazilian medicinal plants for antiviral activity against rotavirus

Human rotavirus vaccine (Rotarix): focus on effectiveness and impact 6 years after first introduction in Africa

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