Constituents from Gymnema sylvestre Leaves. II. Nitrogenous compounds

A novel Gymnema sylvestre extract protects pancreatic beta‐cells from cytokine‐induced apoptosis

“…Efforts have been made to identify the possible bioactive compounds responsible for the antidiabetic effect of GS. Characterization of alcoholic extracts of GS yielded a group of low molecular weight compounds called saponin glycosides (Ahamad, Amin, & Mir, ; Ali Ahmed, Rao, & Rao, ; Dateo & Long, ; Fabio, Romanucci, De Marco, & Zarrelli, ; H. M. Liu, Kiuchi, & Tsuda, ; Murakami et al, ; Rao & Sinsheimer, ; E. R. Shanmugasundaram, Venkatasubrahmanyam, Vijendran, & Shanmugasundaram, ; Sinsheimer & McIlhenny, ; Sinsheimer & Rao, ; Sinsheimer, Rao, & McIlhenny, ; Zhang et al, ; Zhu et al, ). Although several studies have attributed the antidiabetic effect of GS to these chemicals (Baskaran, Kizar Ahamath, Radha Shanmugasundaram, & Shanmugasundaram, ; Di Fabio, Romanucci, Zarrelli, Giordano, & Zarrelli, ; Fabio et al, ; Fushiki, Kojima, Imoto, Inoue, & Sugimoto, ; Kumar et al, ; Murakami et al, ; Reddy, Latha, Vijaya, & Rao, ; Sathya, Kokilavani, & Gurusamy, ; Sugihara et al, ), we suggest that the active constituents in OSA® extract are different.…”

New Pregnane Glycosides from Gymnema sylvestre

“…Pharmacological studies showed that G. sylvestre has hypoglycemic [4,5], anti-caries [6,7] and weight reducing [8,9,10] effects. Triterpenoids [11,12,13,14,15,16,17,18], cyclitols [19], flavonoids [20], peptides [21], pectin [22] and alkaloids [23,24] have been isolated from this plant. Some triterpene saponins from G. sylvestre were found to be able to attenuate hyperglycemia induced by pituitary growth hormone or adrenocorticotropic hormone [25,26] and to inhibit intestinal glucose absorption in diabetic rats [27,28,29,30].…”