Constituents of Endodesmia calophylloides Benth. and Adenia lobata (Jacq.) Engl. with antileihsmanial activities

Koffi, Jean Garba; Keumoe, Rodrigue; Ngansop, Cyrille Armel Njanpa; Kagho, Donald Ulrich Kenou; Tchegnitegni, Billy Toussie; Fongang, Yannick Stéphane Fotsing; Bankeu, Jean Jules Kezetas; Boyom, Fabrice Fekam; Sewald, Norbert; Lenta, Bruno Ndjakou

doi:10.1016/j.cdc.2021.100751

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Twenty-nine compounds were detected and twenty-seven were tentatively identified based on UV absorption and HR-MS n patterns (Table 2), and the major compounds of this plant are presented in Figure 3 and 191.0468 was identified as chlorogenic acid (C16H18O9) [48], and peak 8 was identified as trans-p-coumaric acid (C9H8O3). Peak 6 with a M-H-ion at m/z: 301.0883 was identified as tachioside (C13H18O8) [51], and peak 7 as its isomer isotachioside; and finally, peak 12 was identified as grandisin (C24H32O7) and peak 24 as Albizinin (C27H31O17). Peak 27 with a pseudo molecular ion at m/z: 145.0299 was identified as coumarin (C9H6O2), peak 5 was identified as carboxyumbelliferyl glucuronide (C16H13O11) [52], and peak 15 was identified as dicoumarin edgeworoside C (C24H19O10) [53].…”

Section: Uhplc-ms Analysis Of Extractsmentioning

confidence: 99%

UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

Ramos

Palacios

Barrientos

et al. 2023

Foods

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Azara dentata Ruiz & Pav. is a small Chilean native plant from Patagonia, a producer of small white reddish berries. For the first time, the proximal analysis of the fruits, phenolic fingerprinting, the antioxidant activity, and the enzymatic inhibition and relaxation effects in rat aorta induced by the ethanolic extract of these fruits were investigated. The proximal composition and the mineral (Ca: 2434 ± 40 mg/kg; Mg: 702 ± 13 mg/kg; Fe: 117.1 ± 1.6 mg/kg; Zn: 16.1 ± 0.4 mg/kg) and heavy metal (As: 121 ± 11 µg/kg; Cd: 152 ± 5 µg/kg; Hg: 7.7 ± 1.3 µg/kg; Pb 294 ± 4 µg/kg) contents were analyzed. Anthocyanins, flavonoids, phenolic acids, and coumarins were identified using UHPLC-PDA-QTOF-MS. The ethanolic extracts showed a total phenolic content of 23.50 ± 0.93 mg GAE/g extract. In addition, the antioxidant activity was assessed using both DPPH and TEAC (28.64 ± 1.87 and 34.72 ± 2.33 mg Trolox/g of dry fruit, respectively), FRAP (25.32 ± 0.23 mg Trolox equivalent/g dry fruit), and ORAC (64.95 ± 1.23 mg Trolox equivalents/g dry fruit). The inhibition of enzymatic activities (acetylcholinesterase IC50: 2.87 + 0.23 µg extract/mL, butyrylcholinesterase IC50: 6.73 + 0.07 µg extract/mL, amylase IC50: 5.6 ± 0.0 µg extract/mL, lipase IC50: 30.8 ± 0.0 µg extract/mL, and tyrosinase IC50: 9.25 ± 0.15 µg extract/mL) was also assessed. The extract showed 50–60% relaxation in rat aorta (intact), mediated thorough the release of endothelial nitric oxide. Our results suggest that A. dentata is a good source of compounds with the capacity to inhibit important enzymes, can be hypotensive, and can thus have good potentiality as supplements in the amelioration of neurodegenerative diseases and could also have potential to be used to develop new functional foods. The study highlights the benefits of these neglected small fruits and could boost their consumption.

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Section: Uhplc-ms Analysis Of Extractsmentioning

confidence: 99%

UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

Ramos

Palacios

Barrientos

et al. 2023

Foods

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Steroid and Triterpenoid Compounds with Antiparasitic Properties

Ajduković

Kuzminac

Savić

et al. 2023

CTMC

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Parasitic diseases affect millions of people and animals, predominantly in the tropics, including visitors to tropical countries and other areas. Efficient and low-cost treatments for infections caused by various parasites are not yet available. Antiparasitic drugs have some drawbacks, such as toxicity and the development of resistance by parasites. This has motivated many researchers to focus on the discovery of safe, effective and affordable antiparasitic drugs, both among drugs already available for other diseases and new compounds synthesized or isolated from natural sources. Furthermore, steroid and triterpenoid compounds attract the attention of pharmacologists, chemists and biochemists owing to their broad application in the treatment of various diseases. Isolation of steroid and triterpenoid compounds from natural sources with antiparasitic efficacy is an attractive choice for scientists. On the other hand, these compounds can be transformed into more potent forms by modifying the basic skeleton. This review presents a collection of isolated and synthesized steroid and triterpenoid compounds from 2018 to 2021 that have been reported to be effective against certain parasitic protozoa and helminths. A total of 258 compounds have been identified with antimalarial, antitrypanosomal, antileishmanial, anti-Toxoplasma, and/or anthelmintic activity. The described investigations of antiparasitic compounds may be helpful for further drug development.

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Constituents of Endodesmia calophylloides Benth. and Adenia lobata (Jacq.) Engl. with antileihsmanial activities

Cited by 2 publications

References 28 publications

UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

UHPLC-MS Phenolic Fingerprinting, Aorta Endothelium Relaxation Effect, Antioxidant, and Enzyme Inhibition Activities of Azara dentata Ruiz & Pav Berries

Steroid and Triterpenoid Compounds with Antiparasitic Properties

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