Constituents of Fermented Male Flowers of <i>Alnus sieboldiana</i> (Betulaceae)

Ghani, Nurunajah Ab; Ismail, Nor Hadiani; Asakawa, Yoshinori

doi:10.1177/1934578x1701200116

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…According to the previous literature, peaks 3 and 4 were presumed to be 3’,7-dimethoxy-3-hydroxyflavone isomers. 32 …”

Section: Resultsmentioning

confidence: 99%

“…Fragment ions at m/z 284, m/z267, m/z239, m/z211, m/z181 and m/z153 were probably produced by a series of neutral losses from the parent ion corresponding to [M+H-CH 3 ] + , [M+H-CH 3 -OH] + , [M+H-CH 3 -OH-CO] + , [M+H-CH 3 -OH-(CO) 2 ] + , [M+H-CH 3 -OH-(CO) 2 -CH 2 O] + and [M+H-CH 3 -OH-(CO) 3 -CH 2 O] + ,respectively. According to the previous literature, peaks 3 and 4 were presumed to be 3',7-dimethoxy-3-hydroxyflavone isomers 32. As for peak 5, the[M+H] + ion at m/z 465 was obtained.…”

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confidence: 87%

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Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2

Li¹,

Chen²,

Zhang³

et al. 2022

JIR

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Background Dysosma versipellis ( D. versipellis ) has been traditionally used as a folk medicine for ages. However, the specific phytochemicals responsible for their correlated anti-inflammatory, anti-proliferative and antiviral activities remain unknown. Purpose This study aimed to explore the specific active components in D. versipellis responsible for its potential anti-inflammatory, anti-proliferative, and antiviral effects, and further elucidate the corresponding mechanisms of action. Methods Bioaffinity ultrafiltration coupled to liquid chromatography–mass spectrometry (UF-LC/MS) was firstly hired to fast screen for the anti-inflammatory, anti-proliferative and antiviral compounds from rhizomes of D. versipellis , and then further validation was conducted using in vitro inhibition assays and molecular docking. Results A total of 12, 12, 9 and 12 phytochemicals with considerable affinities to Topo I, Topo II, COX-2 and ACE2 were fished out, respectively. The anti-proliferative assay in vitro indicated that podophyllotoxin and quercetin exhibited comparably strong inhibitory rates on A549 and HT-29 cells compared with 5-FU and etoposide. Meanwhile, kaempferol displayed prominent dose-dependent inhibition against COX-2 with IC 50 value at 0.36 ± 0.02 μM lower than indomethacin at 0.73 ± 0.07 μM. Furthermore, quercetin exerted stronger inhibitory effect against ACE2 with IC 50 value at 104.79 ± 8.26 μM comparable to quercetin 3- O -glucoside at 135.25 ± 6.54 μM. Conclusion We firstly showcased an experimental investigation on the correlations between bioactive phytochemicals of D. versipellis and their multiple drug targets reflecting its potential pharmacological activities, and further constructed a multi-target and multi-component network to decipher its empirical traditional applications. It could not only offer a reliable and valuable experimental basis to better comprehend the curative effects of D. versipellis but also provide more new insights and strategies for other traditional medicinal plants.

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“…According to the previous literature, peaks 3 and 4 were presumed to be 3’,7-dimethoxy-3-hydroxyflavone isomers. 32 …”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 87%

Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2

Li¹,

Chen²,

Zhang³

et al. 2022

JIR

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show abstract

“…The contents of naringenin and pinocembrin were reduced after a 6-month fermentation while new compounds such as kaempferol, quercetin, pinocembrin dimethyl ether, 5,7-dimethoxy-3-hydroxyflavanone, and 5,7-dimethoxy-3-hydroxyflavone were produced through bioconversion. Authors suggested that the hydroxylation of naringenin at positions C-3 and C-3 produced kaempferol and quercetin, respectively, while methylation, hydroxylation, and oxidation of pinocembrin gave three 5,7-dimethoxyflavonoids [42]. Pei et al [43] reported production of kaempferol and astragalin through fermentation.…”

Section: Fermentation Of Plant-based Materials As Source Of Biopestic...mentioning

confidence: 99%

Fermentation as an Alternative Process for the Development of Bioinsecticides

et al. 2020

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Currently, insect pest control is carried out through the application of synthetic insecticides which have been related to harmful effects on both human and environmental health, as well as to the development of resistant pest populations. In this context, the development of new and natural insecticides is necessary. Agricultural and forestry waste or by-products are very low-cost substrates that can be converted by microorganisms into useful value-added bioactive products through fermentation processes. In this review we discuss recent discoveries of compounds obtained from fermented substrates along with their insecticidal, antifeedant, and repellent activities. Fermentation products obtained from agricultural and forestry waste are described in detail. The fermentation of the pure secondary metabolite such as terpenes and phenols is also included.

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Constituents of Fermented Male Flowers of Alnus sieboldiana (Betulaceae)

Cited by 2 publications

References 19 publications

Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2

Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2

Fermentation as an Alternative Process for the Development of Bioinsecticides

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