Constituents of Hypericum japonicum

Wu, Qingli; Wang, Sheng‐Ping; Du, Lijun; Wang, Li‐Wei; Yang, Jun‐Shan; Xiao, Pei‐Gen

doi:10.1002/(sici)1099-1573(1998)12:1+<s164::aid-ptr285>3.0.co;2-g

Cited by 10 publications

(5 citation statements)

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“…1). The known compounds were identified by comparing the physical and spectroscopic data with those in literature as 5,7-dihydroxy-3-methylchromone (3) (Nedialkov and Kitanov, 2002), (-)-epicatechin (4) (Foo and Karchesy, 1989), 1,3,5,6-tetrahydroxyxanthone (5) (Ishiguro et al, 1999), I3, II8-biapigenin (6) (Berghöfer and Hölzl, 1987), quercitrin (7) (Lee et al, 2004), and 3-O-caffeol-quinic acid methyl ester (8) (Wu et al, 1998), respectively.…”

Section: Results and Dicussionsupporting

confidence: 55%

Chromone glycosides and hepatoprotective constituents of Hypericum erectum

An¹,

Jeong

Beom

et al. 2009

Arch. Pharm. Res.

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Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM and 217.7 +/- 1.3 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.

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Section: Results and Dicussionsupporting

confidence: 55%

Chromone glycosides and hepatoprotective constituents of Hypericum erectum

An¹,

Jeong

Beom

et al. 2009

Arch. Pharm. Res.

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“…The NMR data of 1 were very similar to those of 1,5-dihydroxyxanthone 6-O-β-D-glucopyranoside isolated from Hypericum japonicum[15], except that a hydroxy group was replaced by a methoxyl. The linkage position of the methoxyl group was elucidated from the HMBC correlation of 5-OCH3 [δ H 3.96 (3H, s)] with C-5 [δ C 137.2].…”

supporting

confidence: 54%

Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production

Zhou

Zeng

et al. 2013

Planta Med

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Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4'-O-β-D-glucopyranoside (3), japonicumone B 3'-O-β-D-glucopyranoside (4), and japonicumone B 4'-O-β-D-glucopyranoside (5), together with eight known compounds (6-13) were isolated from the whole plants of Arenaria serpyllifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis (UV, IR, HRESIMS, 1D- and 2D-NMR, and CD) as well as chemical methods. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages. Compounds 1-5, sacranoside A (9), and pedunculoside (13) showed potential nitric oxide inhibitory activities with IC50 values ranging from 14.92 µM to 52.23 µM.

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“…The chemical composition of H. japonicum has been studied during the last few years due to the importance and availability of plant. The phytochemical studies on H. japonicum have resulted in the isolation of flavonoids, phloroglucinols and xanthones [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]. In addition, some compounds from other classes were also isolated from this species [6,7,21,22,23,24].…”

Section: Phytochemistrymentioning

confidence: 99%

Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine

Liu

2014

Molecules

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Hypericum japonicum Thunb. ex Murray is mainly distributed throughout Asia, Oceania and North America and is used as an important herbal medicine. H. japonicum contains many valuable secondary metabolites, such as flavonoids, phloroglucinols and xanthones and has hepatoprotective, anti-tumor, antibacterial, antiviral, and antioxidant activities and effects on the cardiovascular system and immunity. Coupled with phytochemical and pharmacological research, a series of analytical methods have been developed to evaluate the quality of H. japonicum based on its bioactive components. A pharmacokinetics study involved the absorption of two main flavonoids of H. japonicum in rats. This review aims to present an up-to-date and comprehensive overview of the phytochemistry, pharmacology, quality control and pharmacokinetics of H. japonicum, which should be useful for the greater development of H. japonicum, especially in the development of new drugs and therapeutics for various diseases.

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Constituents of Hypericum japonicum

Cited by 10 publications

References 0 publications

Chromone glycosides and hepatoprotective constituents of Hypericum erectum

Chromone glycosides and hepatoprotective constituents of Hypericum erectum

Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production

Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine

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